Determination of heavy metal ions based on quenching of the rare earth luminescence

Arakawa, Tsuyoshi; Muraki, Akiko; Hashimoto, Mizuki

doi:10.1016/j.snb.2004.11.060

Cited by 10 publications

(2 citation statements)

References 8 publications

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“…This compound has many applications in field emission display, cathode ray tubes, phosphor lamps and liquid crystal display back colors [3][4][5][6][7][8]. There are many reports on application of rare earth complexes (especially Eu) in sensing, biological and immunoassay fields [9][10][11][12][13]. However, biological applications of rare earth doped nanoparticles are rarely reported.…”

Section: Introductionmentioning

confidence: 99%

Y2O3: Eu,Zn nanocrystals as a fluorescent probe for the detection of biotin

et al. 2012

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We report on the application of nanocrystals (NCs) of the type Y 2 O 3 : Eu,Zn as a probe for the fluorescent detection of biotin in aqueous solution. The NCs were dispersed in water in the presence of various surface modifiers including mercaptoethanol (ME), monoethanolamine and ethylene glycol. Both the absorbance of surfactant and the stability of the suspensions were investigated in order to optimize the experimental conditions. ME is found to be the most suitable surfactant for stabilization of the suspended NCs. Their photoluminescence intensity is found to be quenched by biotin. The Stern-Volmer constant for the quenching process is 7.6× 10 3 M −1 . This NC probe can be applied to the detection of biotin in the 1-60 μM concentration range with detection limit of 1.89 μM. The possible mechanisms of quenching also are discussed.

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Section: Introductionmentioning

confidence: 99%

Y2O3: Eu,Zn nanocrystals as a fluorescent probe for the detection of biotin

et al. 2012

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“…The principle advantages of this technology rely on its high sensitivity, which allows easy measurement of low analyst concentrations and its selectivity due to the excitation and emission wavelengths of each fluorescent species [1][2][3][4]. Fluorescent organic chelators, proteins, and peptides have emerged as powerful receptors for dosing with HTM ions, and remarkable progress has been made in developing fluorophore molecules for metal ions such as Ca ++ , Zn ++ , Pb ++ , Hg ++ , Cu ++ , and Ag + ions [5][6][7][8][9][10][11][12][13][14][15][16][17][18]. These systems are generally composed of a substrate binding unit and one or more chemophore molecules which can enhance (or generate) or quench the fluorescence signal when complexing HTM ions.…”

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confidence: 99%

Design and synthesis of fluorescence-based siderophore sensor molecules for FeIII ion determination

Moniotte

Nivarlet

et al. 2010

Pure and Applied Chemistry

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The design principles of fluorescence-based siderophore sensor molecules for detection of heavy transition-metal (HTM) ions are first reviewed. As an example, fluorescein-desferrioxamine (FlDFO), a highly efficient fluorophore molecule combining a specific Fe ion receptor and a fluorescence-sensitive signalling site has been designed, synthesized, and used for dosing with Fe ions. Its response test shows its high selectivity and sensitivity to Fe III ions and its potential for nanobiosensor design. This work clearly identified that among two FlDFO positional isomers differing by the attachment of DFO at the 5-or 6-position of the bottom benzene ring of Fl, the fluorescence of 6-FlDFO is insensitive to the complexation with Fe ions. This is independent of the linkage used between Fl and DFO. Only 5-FlDFO could be a highly potential sensor molecule since it has been revealed that in a free state without complexation with Fe ions, this fluoroionophore sensor molecule gave a maximum fluorescent signal. With successive Fe ion complexing, the fluorescence of 5-FlDFO decreased very sensitively and proportionally with ion concentration. The response speed has been evaluated as a function of Fe ion concentration. Responses to other metal ions present in the solution, such as Cu 2+ , Ca 2+ , Ni 2+ , and Al 3+ , and the effect of pH value on the efficiency of the sensor molecules have also been investigated.processes. Furthermore, some metal ions such as mercury, lead, and cadmium are known to be toxic for the organisms. Early detection in the environment is becoming a priority for society.The quantification of metal ions can be achieved by a series of chemical and analytic methods such as colorimetry, flame photometry, UV-vis spectrophotometry, atomic absorption spectrometry, ion-sensitive electrodes (ISEs), electron microprobe analysis, neutron activation analysis, inductively coupled plasma-mass spectrometry (ICP-MS), etc. However, these methods have certain shortcomings because they are generally expensive and voluminous and often require samples of large size and sometimes the destruction of the samples. Furthermore, these methods do not allow continuous monitoring.The development of sensitive and selective fluorescent nanosensors for dosing with heavy transition-metal (HTM) ions has recently attracted great attention due to their importance in the fields of environ mental monitoring, clinical toxicology, wastewater treatment, and industrial process monitoring [1][2][3][4]. The principle advantages of this technology rely on its high sensitivity, which allows easy measurement of low analyst concentrations and its selectivity due to the excitation and emission wavelengths of each fluorescent species [1][2][3][4]. Fluorescent organic chelators, proteins, and peptides have emerged as powerful receptors for dosing with HTM ions, and remarkable progress has been made in developing fluorophore molecules for metal ions such as Ca ++ , Zn ++ , Pb ++ , Hg ++ , Cu ++ , and Ag + ions [5][6][7][8][9][10][11][12][13][14][15][16][17...

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A simple and rapid spectrofluorimetric method for determining the pharmacokinetics and metabolism of rhaponticin in rat plasma, feces and urine using a cerium probe

2013

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Rhaponticin (RH) demonstrates a variety of pharmacological activities, including antitumor, antithrombotic and antioxidant effects. It is essential to establish a simple, rapid and reliable analytical method for determining the pharmacokinetics of RH. A simple cerium ion (Ce(3+)) probe method was developed and validated to determine RH in rat plasma, feces and urine. The fluorescence intensities of the cerium ion (Ce(3+)) were quenched by addition of RH, along with a remarkable red shift. Spectral data revealed that fluorescence quenching of Ce(3+) by RH was due to the formation of a Ce(3+)-RH complex. Using to the Stern-Volmer equation, the binding parameters for interactions between Ce(3+) and RH were obtained. Based on these, a rapid and simple spectrofluorimetric method was developed to determine the metabolism and pharmacokinetics of RH using a Ce(3+) probe. The assay was linear over the concentration range of 0.11-9.52, 0.25-8.87 and 0.18-9.10 μM for plasma, feces and urine, respectively and RH recoveries were found to be 98.24 ± 0.8, 97.78 ± 1.2 and 97.54 ± 0.8% for plasma, feces and urine, respectively. The relative standard deviations were < 9.5%. The spectrofluorimetric method was simple and rapid for quantitative determination of RH and its metabolism, and was affordable for most laboratories because of the fluorescence spectroscopy and low equipment cost. These pharmacokinetic, bioavailability and metabolism studies of RH will provide helpful information for the development of suitable dosage forms and clinical references on rational administration.

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Determination of heavy metal ions based on quenching of the rare earth luminescence

Cited by 10 publications

References 8 publications

Y2O3: Eu,Zn nanocrystals as a fluorescent probe for the detection of biotin

Y2O3: Eu,Zn nanocrystals as a fluorescent probe for the detection of biotin

Design and synthesis of fluorescence-based siderophore sensor molecules for FeIII ion determination

A simple and rapid spectrofluorimetric method for determining the pharmacokinetics and metabolism of rhaponticin in rat plasma, feces and urine using a cerium probe

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