Determination of HBsAg subtypes in Western Siberian part of Russia

Нетесова, И. Г.; Swenson, Paul D.; Osipova, L. P.; Gubina, Marina; Posukh, Olga L.; Нетесов, С. В.

doi:10.1002/jmv.10468

Cited by 11 publications

(8 citation statements)

References 18 publications

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“…In Western Siberia, the genotype D constitutes even more than 96 % of the total. In contrast to Latvia, the ayw2 subtype was clearly predominant over the ayw3 subtype [47]. Our data also support the postulate, that genotype D is predominant in the Mediterranean region, Southern and Eastern Europe, in such countries as Hungary [48], Italy: 73% of the genotype D, and 26% of the genotype A [49,50], and Spain: 63,2% and 23.1%, respectively [51,52].…”

Section: Hbv Genotypes In Latvia and Neighboring Countriessupporting

confidence: 77%

Hepatitis B Virus Genotypes in Latvia

Sominskaya¹

2011

TOHEPATJ

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Abstract:The aim of this study was to investigate the properties of HBV genomes isolated from patients with acute and chronic hepatitis, liver cirrhosis, and hepatic coma admitted to the Infectology Center of Latvia. HBV genotypes and HBsAg subtypes were determined by direct S-gene sequencing. Genotypes D (72.17%) and A (27.96%) were predominant. Only one case (0.87%) of HBV genotype E was found. Prevalence of genotype D over genotype A was more strongly pronounced in isolates from patients with acute hepatitis than from patients with chronic hepatitis-74%-24% and 68%-32%, respectively. Number of previously described and some new mutations (Ser21Thr in preC region, Tyr134Lys, Phe134Leu, Ile110Met, Thr118Ile and Ser136Tyr in S-gene) were discovered by direct sequencing of PCR fragments corresponding to preS/S and preC/C regions and to a fragment of the X gene of HBV genome. The most frequently mutations were found in the region of the basal core promoter, preC and major immunodominant region of core protein and domain a of S protein. In general the rate of mutations discovered in chronic patients was just 1,23 times higher then in patients with acute hepatitis, at the same time the ratio for the hot-spot preC 1896 stop mutation was higher and reached 1,81. A possible role of discovered mutations in the HBV pathogenesis is discussed. The findings are relevant to diagnosis and prognosis of HBV-induced liver disease.

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Section: Hbv Genotypes In Latvia and Neighboring Countriessupporting

confidence: 77%

Hepatitis B Virus Genotypes in Latvia

Sominskaya¹

2011

TOHEPATJ

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“…Thus, all genotype A strains specified adw2, the single strain specifying adrqþ belonged to genotype C. The most prevalent subtypes in genotype D were ayw3 and ayw2 with a tendency to segregation into separate clusters. Using a panel of monoclonal antibodies Netesova et al [2003] reported a 94% prevalence of ayw3variantA in drug users. While this subtype was found in 11% of blood donors it was absent in the native population of West Siberia.…”

Section: Discussionmentioning

confidence: 98%

Hepatitis B virus genotype D strains from Estonia share sequence similarity with strains from Siberia and May specify ayw4

Tallo

Nordér

Tefanova

et al. 2004

Journal of Medical Virology

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The genotypes and subtypes of 205 HBV isolates collected during 1989-2002 in Estonia and 14 other regions of the former USSR were determined by sequencing and phylogenetic analysis of the S gene. The in Europe prevailing genotypes, A and D, were also circulating in the whole territory of the former USSR including Estonia and accounted for 18.5 and 81% of the strains, respectively. All genotype A strains specified adw2, and a single genotype C strain specified adrq+. Most genotype D strains specified ayw3 and ayw2, although, three strains from Estonia and Siberia specified ayw4. Due to unique substitutions, Ser122 and Ala127, four strains could not be classified according to the subtype. One strain specifying ayw3 encoded Leu143 and Ala145 and was possibly an immune "escape" mutant. At phylogenetic analysis 93% of the Estonian genotype D strains belonged to a cluster specifying mainly ayw3 and were more similar to isolates from Siberia and the Far-East of Russia than to isolates originating from Central Russia which belonged to another cluster of strains specifying mainly ayw2. This pattern might be explained by part of the Estonian population, has roots east of European Russia, based on linguistic evidence. Eight dominant HBV strains represented by identical S gene sequences were identified, one within genotype A and seven within genotype D, three of which included isolates from Estonia and Siberia. Some of these strains were collected over a period of at least 13 years indicating there are genetically stable variants of HBV that remain conserved over decades.

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“…Interestingly, similar studies that used samples obtained before national hepatitis B immunization programs were launched (2001 [41]) yielded lower estimates of herd immunity. Thus, [75,76] …”

Section: Seroepidemiological Studiesmentioning

confidence: 99%

Untitled

2017

Bulletin of RSMU

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Determination of HBsAg subtypes in Western Siberian part of Russia

Cited by 11 publications

References 18 publications

Hepatitis B Virus Genotypes in Latvia

Hepatitis B Virus Genotypes in Latvia

Hepatitis B virus genotype D strains from Estonia share sequence similarity with strains from Siberia and May specify ayw4

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