Determination of green‐bond strength in tacky poly(vinyl alcohol) hydrogels

Ben-Zion, O.; Karpasas, Mark; Nussinovitch, A.

doi:10.1002/app.11587

Cited by 6 publications

(3 citation statements)

References 16 publications

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“…The ability of PVA to hold hFDM on its surface may be attributed to the adhesive nature of PVA hydrogel 28 . Interestingly, formation of this “green-bond” is one of the essential properties of adhesive hydrogels as dressing materials 29 . Another possibility is the physical interactions that enable the formation of a mechanical interlock between hFDM and PVA.…”

Section: Discussionmentioning

confidence: 99%

Novel skin patch combining human fibroblast-derived matrix and ciprofloxacin for infected wound healing

et al. 2018

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Skin injuries are frequently encountered in daily life, but deep wounds often poorly self-heal and do not recover completely. In this study, we propose a novel skin patch that combines antibiotic, cell-derived extracellular matrix (ECM) and biocompatible polyvinyl alcohol (PVA) hydrogel.Methods: Decellularized human lung fibroblast-derived matrix (hFDM) was prepared on tissue culture plate (TCP) and PVA solution was then poured onto it. After a freeze-thaw process, PVA was peeled off from TCP along with hFDM tightly anchored to PVA. Subsequently, ciprofloxacin (Cipro)-incorporated PVA/hFDM (PVA/Cipro/hFDM) was fabricated via diffusion-based drug loading.Results: In vitro analyses of PVA/Cipro/hFDM show little cytotoxicity of ciprofloxacin, stability of hFDM, rich fibronectin in hFDM, and good cell attachment, respectively. In addition, hFDM proved to be beneficial in promoting cell migration of dermal fibroblasts and human umbilical vein endothelial cells (HUVECs) using transwell inserts. The antibacterial drug Cipro was very effective in suppressing colony growth of gram-negative and -positive bacteria as identified via an inhibition zone assay. For animal study, infected wound models in BALB/c mice were prepared and four test groups (control, PVA, PVA/Cipro, PVA/Cipro/hFDM) were administered separately and their effect on wound healing was examined for up to 21 days. The results support that Cipro successfully reduced bacterial infection and thus encouraged faster wound closure. Further analysis using histology and immunofluorescence revealed that the most advanced skin regeneration was achieved with PVA/Cipro/hFDM, as assessed via re-epithelialization, collagen texture and distribution in the epidermis, and skin adnexa (i.e., glands and hair follicles) regeneration in the dermis.Conclusion: This work demonstrates that our skin patch successfully consolidates the regenerative potential of ECM and the antibacterial activity of Cipro for advanced wound healing.

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Section: Discussionmentioning

confidence: 99%

Novel skin patch combining human fibroblast-derived matrix and ciprofloxacin for infected wound healing

et al. 2018

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“…[156] Bond strength is an important factor in transdermal patches, and high strength freeze-thawed poly(vinyl alcohol) gels have been tested. [157,158] Optimization of a polyacrylic acid-HEMA gel for bond strength has also been reported. [159] In both these reports, bond strength (tack) was about 0.1 N mm…”

Section: Drug-delivery Systemsmentioning

confidence: 97%

Hydrogels for Soft Machines

2009

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Hydrogels have applications in surgery and drug delivery, but are never considered alongside polymers and composites as materials for mechanical design. This is because synthetic hydrogels are in general very weak. In contrast, many biological gel composites, such as cartilage, are quite strong, and function as tough, shock‐absorbing structural solids. The recent development of strong hydrogels suggests that it may be possible to design new families of strong gels that would allow the design of soft biomimetic machines, which have not previously been possible.

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“…Tack is defined as the ability to instantaneously stick to a substrate under low pressure and be easily removed by adhesive separation (without leaving any residue at the substrate surface). Indeed, for viscoelastic materials to have the property of tack, adhesion must be developed during the bonding step and cohesion during the debonding step [5][6][7][8]. Tack is not a simple materials property such as density or modules but is rather a composite response of the adhesives surface chemical and bulk physical properties upon being brought into contact with another material [9,10].…”

Section: Introductionmentioning

confidence: 99%