Determination of glyphosate in breast milk of lactating women in a rural area from Paraná state, Brazil

Camiccia, M; Candiotto, Luciano Zanetti Pessôa; Gaboardi, Shaiane Carla; Kottwitz, Luciana Bill Mikito

doi:10.1590/1414-431x2022e12194

Cited by 11 publications

(4 citation statements)

References 21 publications

(20 reference statements)

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“…Our findings strengthen several worldwide studies demonstrating augmented breast cancer risk in pesticide occupationally exposed women (47)(48)(49)(50)(51)(52)(53)(54)(55) by adding information about possibly implicated mechanisms in the pre-carcinogenic stages. Detecting pesticides in urine, blood, breast milk, and mammary tissue samples from exposed women reinforces the idea that they may have a systemic impact (14,(56)(57)(58).…”

Section: Discussionmentioning

confidence: 66%

Brief research report pesticide occupational exposure leads to significant inflammatory changes in normal mammary breast tissue

da Silva,

Ferreira,

Komori

et al. 2023

Front. Public Health

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Studies have documented the high occurrence of several tumors, including female breast cancer, in populations occupationally exposed to pesticides worldwide. It is believed that in addition to direct DNA damage, other molecular alterations that indicate genomic instability are associated, such as epigenetic modifications and the production of inflammation mediators. The present study characterized the profile of inflammatory changes in the breast tissue of women without cancer occupationally exposed to pesticides. In samples of normal breast tissue collected during biopsy and evaluated as negative for cancer by a pathologist, oxidative stress levels were assessed as inflammatory markers through measurements of lipoperoxides and total antioxidant capacity of the sample (TRAP) by high-sensitivity chemiluminescence, as well as levels of nitric oxide (NOx) metabolites. The levels of inflammation-modulating transcription factors PPAR-γ (peroxisome proliferator-activated receptor gamma) and NF-κB (nuclear factor kappa B) were also quantified, in addition to the pro-inflammatory cytokines tumor necrosis factor-alpha (TNF-α) and interleukin 12 (IL-12). The levels of lipoperoxides, TRAP, and NOx were significantly lower in the exposed group. On the other hand, PPAR-γ levels were increased in the breast tissue of exposed women, with no variation in NF-κB. There was also a rise of TNF-α in exposed women samples without significant variations in IL-12 levels. These findings suggest an inflammatory signature of the breast tissue associated with pesticide exposure, which may trigger mechanisms related to mutations and breast carcinogenesis.

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Section: Discussionmentioning

confidence: 66%

Brief research report pesticide occupational exposure leads to significant inflammatory changes in normal mammary breast tissue

da Silva,

Ferreira,

Komori

et al. 2023

Front. Public Health

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“…Studies have shown that glyphosate and AMPA are present in the bodies of the population, indicating a collective health problem. Examples include the studies by Palma et al [ 30 ] and Camiccia et al [ 31 ], which detected glyphosate in breast milk samples from infants in the Midwest and South of Brazil, respectively, demonstrating that babies are also vulnerable, despite having developing immune systems.…”

Section: Glyphosate Usementioning

confidence: 99%

Glyphosate as a Food Contaminant: Main Sources, Detection Levels, and Implications for Human and Public Health

de Morais Valentim,

Coradi,

Viana

et al. 2024

Foods

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Glyphosate is a broad-spectrum pesticide that has become the most widely used herbicide globally. However, concerns have risen regarding its potential health impacts due to food contamination. Studies have detected glyphosate in human blood and urine samples, indicating human exposure and its persistence in the organism. A growing body of literature has reported the health risks concerning glyphosate exposure, suggesting that the daily intake of contaminated food and water poses a public health concern. Furthermore, countries with high glyphosate usage and lenient regulations regarding food and water contamination may face more severe consequences. In this context, in this review, we examined the literature regarding food contamination by glyphosate, discussed its detection methods, and highlighted its risks to human health.

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“…Adapted from [18,19]. References (water [26,[29][30][31][32][33], food [13,[34][35][36], and humans [37][38][39]).…”

Section: Figurementioning

confidence: 99%

Effects of Glyphosate or Glyphosate-Based Herbicide during the Zebrafish Life Cycle: A Review Addressing the Mechanisms of Toxicity

Lanzarin

Félix

Fontaínhas‐Fernandes

et al. 2023

Water

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Herbicides with glyphosate (GLY) as an active ingredient (a.i.) are increasingly used, and GLY is currently the most used herbicide in the world. Consequently, its residues have often been found in aquatic ecosystems. Investigating how this substance affects aquatic species is a priority in ecotoxicology research, especially in fish, as they can absorb and concentrate toxins. In this sense, a critical review was performed, synthesizing data from the peer-reviewed bibliography, reporting on the toxicity of exposure to pure GLY and glyphosate-based herbicides (GBHs), using zebrafish as an animal model. The concentrations of this herbicide that induced toxic effects are highly variable, with some exceeding the limits determined by regulatory agencies. Globally, relevant toxic effects have been reported in zebrafish, namely, teratogenic effects incompatible with life, which translates directly into an increase in reported zebrafish mortality. Neurotoxicity, genotoxicity, changes in energy metabolism and oxidative stress, and immune and hormonal system dysfunction with an impact on fish reproduction were also described. In conclusion, both GLY and GBHs may induce damage to zebrafish, compromising their survival, reproduction, and maintenance. These results may be valid and applied to other fish species and aquatic ecosystems.

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Determination of glyphosate in breast milk of lactating women in a rural area from Paraná state, Brazil

Cited by 11 publications

References 21 publications

Brief research report pesticide occupational exposure leads to significant inflammatory changes in normal mammary breast tissue

Brief research report pesticide occupational exposure leads to significant inflammatory changes in normal mammary breast tissue

Glyphosate as a Food Contaminant: Main Sources, Detection Levels, and Implications for Human and Public Health

Effects of Glyphosate or Glyphosate-Based Herbicide during the Zebrafish Life Cycle: A Review Addressing the Mechanisms of Toxicity

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