Determination of glyphosate, glyphosate metabolites, and glufosinate in human serum by gas chromatography–mass spectrometry

Motojyuku, Megumi; Saito, Takeshi; Akieda, Kazuki; Otsuka, Hiroyuki; Yamamoto, Ikuo; Inokuchi, Sadaki

doi:10.1016/j.jchromb.2008.10.003

Cited by 115 publications

(81 citation statements)

References 14 publications

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“…16 The overall recoveries achieved using that method were 37.5 -41.6%. However, the extraction recovery of the present method was very low, even without protein precipitation.…”

Section: Matrix Effects and Recoverymentioning

confidence: 90%

“…[14][15][16] Both the extraction and derivatization times of the present method and the previous methods were compared. In the present method, the sample-preparation process prior to injection into the GC-MS takes approximately 15 min, which presents a one-third reduction of the extraction time.…”

Section: Methods Comparisonmentioning

confidence: 99%

“…[9][10][11][12] GLUF and GLYP have been assayed using a variety of analytical methods, including GC-MS [13][14][15][16] and LC-MS. 17 In patients with GLUF or GLYP poisoning, the blood GLUF or GLYP concentration ranges from 6.9 to 664.7 μg/ml. 12,14,16 Relative to the total number of patients transported to our hospital for the treatment of substance overdose, such as antidepressants and/or antipsychotics, the number of patients experiencing pesticide poisoning has decreased by contrast. Although pesticide is less frequently analyzed, screening and/or quantity analyses are more important in the case of pesticide poisoning than the quantity analysis of antidepressants and/or antipsychotics.…”

Section: Introductionmentioning

confidence: 99%

“…Although we have reported the simultaneous analysis of GLUF and GLYP using a Sep-Pak ® Plus PS-2 cartridge and GC-MS, 16 the process of solvent evaporation is time consuming. Moreover, organophosphate cannot be extracted using this cartridge.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Mix-mode TiO-C18 Monolith Spin Column Extraction and GC-MS for the Simultaneous Assay of Organophosphorus Compounds and Glufosinate, and Glyphosate in Human Serum and Urine

et al. 2011

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“…16 The overall recoveries achieved using that method were 37.5 -41.6%. However, the extraction recovery of the present method was very low, even without protein precipitation.…”

Section: Matrix Effects and Recoverymentioning

confidence: 90%

Section: Methods Comparisonmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Mix-mode TiO-C18 Monolith Spin Column Extraction and GC-MS for the Simultaneous Assay of Organophosphorus Compounds and Glufosinate, and Glyphosate in Human Serum and Urine

et al. 2011

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“…Derivatization with p-toluenesulfonyl chloride [12], p-nitrobenzoyl chloride [38], 9-fluorenylmethyl chloroformate (FMOC-Cl) [39][40][41], (+)-1-(9-fluorenyl)ethyl chloroformate [42], trimethyl orthoacetate, or N-methyl-N-(tertbutyldimethylsilyl)trifluoroacetamide [43], makes the determination both tedious and time-consuming.…”

Section: Introductionmentioning

confidence: 99%

Liquid chromatographic determination of glyphosate and aminomethylphosphonic acid residues in rapeseed with MS/MS detection or derivatization/fluorescence detection

Kaczyński

Łozowicka

2015

Open Chemistry

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Multidentate Anion Receptors for Binding Glyphosate Dianion: Structure and Affinity

et al. 2017

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For the first time, the relationships between anion receptor structures and their glyphosate dianion (Gly2–) binding affinity have been investigated. For this purpose, 12 multidentate bis‐indolocarbazole, bis‐urea and bis‐carbazole based synthetic receptors were synthesized and their binding affinities towards Gly2– were measured in H2O/DMSO media (0.5 % to 20 % of H2O). Computational geometries, as well as 1D and 2D NMR experiments were used to elucidate the structures of the complexes formed on binding of Gly2–. As expected, binding affinity depends strongly on the spatial position of the binding moieties, which, in turn, depend on the spacer length and rigidity. However, the relationships are not straightforward and, in some cases, are counterintuitive. Evidence is presented that, for several receptors, binding occurs through the phosphonate moiety only. One of the receptors described here has, to our knowledge, the strongest affinity towards Gly2– ever reported.

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Determination of glyphosate, glyphosate metabolites, and glufosinate in human serum by gas chromatography–mass spectrometry

Cited by 115 publications

References 14 publications

Mix-mode TiO-C18 Monolith Spin Column Extraction and GC-MS for the Simultaneous Assay of Organophosphorus Compounds and Glufosinate, and Glyphosate in Human Serum and Urine

Mix-mode TiO-C18 Monolith Spin Column Extraction and GC-MS for the Simultaneous Assay of Organophosphorus Compounds and Glufosinate, and Glyphosate in Human Serum and Urine

Liquid chromatographic determination of glyphosate and aminomethylphosphonic acid residues in rapeseed with MS/MS detection or derivatization/fluorescence detection

Multidentate Anion Receptors for Binding Glyphosate Dianion: Structure and Affinity

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