Determination of glyphosate and its metabolite in emergency room in Korea

Han, Joseph K.; Moon, Hantae; Hong, Yeh-Sun; Yang, Songhee; Jeong, Wonjoon; Lee, Kwang-Sik; Chung, Heesun

doi:10.1016/j.forsciint.2015.12.049

Cited by 20 publications

(15 citation statements)

References 30 publications

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“…Finally, Benachour and Séralini (2009) proved that AMPA causes umbilical membrane cell damages and occasionally embryonic or neonatal cells death. No occurrence study has been conducted on blood outside of acute poisoning cases, in which AMPA can reach 2.6 µg/mL of blood (Han et al, 2016). Surprisingly, Li et al (2013) showed that AMPA and glyphosate inhibit growth of cancer cells, but not of healthy cells.…”

Section: Ampa Public Health Concernsmentioning

confidence: 99%

AminoMethylPhosphonic acid (AMPA) in natural waters: Its sources, behavior and environmental fate

Piel²,

2017

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The widely occurring degradation product aminomethylphosphonic acid (AMPA) is a result of glyphosate and amino-polyphosphonate degradation. Massive use of the parent compounds leads to the ubiquity of AMPA in the environment, and particularly in water. The purpose of this review is to summarize and discuss current insights into AMPA formation, transport, persistence and toxicity. In agricultural soils, AMPA is concentrated in the topsoil, and degrades slowly in most soils. It can reach shallow groundwater, but rarely managed to enter deep groundwater. AMPA is strongly adsorbed to soil particles and moves with the particles towards the stream in rainfall runoff. In urban areas, AMPA comes from phosphonates and glyphosate in wastewater. It is commonly found at the outlets of Wastewater Treatment Plants (WWTP). Sediments tend to accumulate AMPA, where it may be biodegraded. Airborne AMPA is not negligible, but does wash-out with heavy rainfall. AMPA is reported to be persistent and can be biologically degraded in soils and sediments. Limited photodegradation in waters exists. AMPA mainly has its sources in agricultural leachates, and urban wastewater effluents. The domestic contribution to urban loads is negligible. There is a critical lack of epidemiological data - especially on water exposure - to understand the toxicological effects, if any, of AMPA on humans. Fortunately, well operated water treatment plants remove a significant proportion of the AMPA from water, even though there are not sufficient regulatory limits for metabolites.

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Section: Ampa Public Health Concernsmentioning

confidence: 99%

AminoMethylPhosphonic acid (AMPA) in natural waters: Its sources, behavior and environmental fate

Piel²,

2017

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“…Furthermore, glyphosate was extracted from food samples using various solvents including water (pH 6.5), MeOH and acetonitrile. 10,46 Therefore, in order to know the best solvent for the extraction of glyphosate from food samples, initially we studied the extraction efficiency of glyphosate using water and polar organic solvents (MeOH and EtOH) and its recovery was determined by afore said procedure. To this, the collected potato sample was fortied with 500, 750 and 1000 nM of glyphosate for 24 h at room temperature.…”

Section: Practical Applicationmentioning

confidence: 99%

Mg²⁺ ion as a tuner for colorimetric sensing of glyphosate with improved sensitivity via the aggregation of 2-mercapto-5-nitrobenzimidazole capped silver nanoparticles

et al. 2016

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“…In another study conducted in Korea, glyphosate was detected at range of 1×10 3 -171.1×10 3 µg/L in the blood of female patients (one in human milk) admitted to the emergency room at a university hospital in Korea after glyphosate was self-administered in suicide attempts or by accident. The study illustrated a correlation between the concentration of glyphosate and the clinical symptoms [17]. There was one study in milk samples of lactating women that could not detect either glyphosate or AMPA (LOD and LOQ of 1 and 10 µg/L) [11] as shown in Table 3.…”

Section: Country Reference Concentrationmentioning

confidence: 92%

“…AMPA can be detected in urine at a lower concentration limit of 0.03 µg/L by LC-MS method [10] and 0.15 µg/L by GC-MS/MS [14]. In blood samples, glyphosate can be detected at a minimum of 50 µg/L (LOD) by LC-MS/MS [17] or 10 µg/L by GC-MS [16]. Techniques used to analyze internal exposure measurement as biomarkers were rather more varied than techniques that analyzed glyphosate in ambient air.…”

Section: Analytical Techniques Of Glyphosate Detection From Human Expmentioning

confidence: 99%

Human Exposure to Glyphosate and Methods of Detection: A Review

Chaiklieng

Uengchuen

2020

Walailak J Sci & Tech

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Glyphosate is a broad-spectrum herbicide used extensively worldwide. The carcinogenic potential of glyphosate has been debated. This review aimed to describe human exposure, report environmental air concentrations in relation to occupational exposure, and identify the methods used to analyze glyphosate or AMPA concentrations. We searched, Google Scholar, Science Direct and PubMed for relevant papers in Thai or English, published from 2004 to 2017. Thus, 16 studies were identified. The results show that glyphosate and aminomethylphosphonic acid (AMPA) are markers of both internal and external exposure dose. Glyphosate is generally detected at concentrations comparable to or higher than AMPA. Human exposure has been assessed with measured levels of glyphosate ranging from 0.02 to 233 µg/L and a range of AMPA of 0.15 to 2.63 µg/L in human urine. The highest concentrations of glyphosate and AMPA found in blood were 171.1×103 and 2,600 µg/L, respectively, from acute poisonings and intentional self-harm. Environmental air concentrations of glyphosate ranged from less than 0.01 to 46.80 µg/m3 in the working field areas. Four methods used to analyze glyphosate and AMPA were identified: ELISA, HPLC-fluorescence/MS, GC-MS, LC-MS. While these results indicate the level of human exposure to glyphosate, the resulting human health effects of exposure are still uncertain. Therefore, there is a need for more investigation into human health risk assessment and application of health surveillance programs, particularly among glyphosate applicators.

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Determination of glyphosate and its metabolite in emergency room in Korea

Cited by 20 publications

References 30 publications

AminoMethylPhosphonic acid (AMPA) in natural waters: Its sources, behavior and environmental fate

AminoMethylPhosphonic acid (AMPA) in natural waters: Its sources, behavior and environmental fate

Mg²⁺ ion as a tuner for colorimetric sensing of glyphosate with improved sensitivity via the aggregation of 2-mercapto-5-nitrobenzimidazole capped silver nanoparticles

Human Exposure to Glyphosate and Methods of Detection: A Review

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Determination of glyphosate and its metabolite in emergency room in Korea

Cited by 20 publications

References 30 publications

AminoMethylPhosphonic acid (AMPA) in natural waters: Its sources, behavior and environmental fate

AminoMethylPhosphonic acid (AMPA) in natural waters: Its sources, behavior and environmental fate

Mg2+ ion as a tuner for colorimetric sensing of glyphosate with improved sensitivity via the aggregation of 2-mercapto-5-nitrobenzimidazole capped silver nanoparticles

Human Exposure to Glyphosate and Methods of Detection: A Review

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Resources

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Mg²⁺ ion as a tuner for colorimetric sensing of glyphosate with improved sensitivity via the aggregation of 2-mercapto-5-nitrobenzimidazole capped silver nanoparticles