Determination of glyburide, glimepiride and repaglinide in wastewater samples

Iancu, Vasile; Radu, Gabriel Lucian; Petre, Jana; Galaon, Toma; Scutariu, Roxana Elena; Pirvu, Florinela; Păun, Iuliana; Serban, Gabriel Valentin

doi:10.21698/simi.2019.ab27

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“…The physical/chemical properties of selected compounds are presented in In Romania, data on the presence of antidiabetics in surface waters, intended for the production of drinking water, are not available. In general, environmental studies on pharmaceutical contaminants have focused on the following chemical classes: antibiotics (macrolides, sulfonamides, quinolones, penicillin's, tetracyclines), non-steroidal anti-inflammatory drugs (NSAIDs), antiepileptics, lipid regulators [23][24][25][26][27][28][29][30]. Also, multiple studies have been carried out for the emerging contaminants of the type of metallic elements present in the environmental components which are not regulated in the national environmental legislation [31,32].…”

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confidence: 99%

Determination of Hypoglycemic Agents in Surface Water Samples Using SPE-LC-MS/MS Method

Iancu¹,

Niculescu²,

Puiu³

et al. 2020

Rev. Chim.

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Antidiabetic compounds are a class of emerging contaminants in environment, for which there are no regulations in the world environmental legislation. These compounds are among the most widely used drugs in the world due to the large number of patients with diabetic conditions. The presence of these pollutants in the environment is insufficiently studied, so efficient analytical methods are needed to allow their detection at trace levels (ng/L). For the simultaneously quantification of the five antidiabetics (glyburide, metformin, glipizide, gliclazide, glimepiride) and one bio-degradation product (guanyl urea) in surface water samples a SPE-LC-MS/MS (solid phase extraction -liquid chromatography coupled with mass spectrometry detection) method was validated using real river water samples. The compounds were separated on C18 LC column in 9 minutes at 300C using a gradient of mobile phase of 0.1% formic acid and acetonitrile. Good performance parameters were obtained using the method: low limits of quantification (LOQs 0.1-2.4 ng/L), precision (repeatability 3.5-7.2% and reproducibility 6.5-12.7%) and determination coefficients (higher than 0.99). The most contaminated river was represented by Ialomita, which had a total concentration of antidiabetics of 112.1 ng/L in the downstream point, followed by the Siret and Dambovita rivers, which had a total concentration of antidiabetics of 66.3 ng/L and 57.3 ng/L, respectively, also in the downstream points.

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