Determination of genetic variation within the &amp;lt;i&amp;gt;DYRK2&amp;lt;/i&amp;gt; gene and its associations with milk traits in cattle

Mao, Chenchen; Ju, Xing; Cheng, Haijian; Huang, Xixia; Jiang, Fugui; Yao, Yuni; Lan, Xianyong; Song, Enliang

doi:10.5194/aab-63-315-2020

Cited by 3 publications

(1 citation statement)

References 39 publications

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“…OSMR gene was discovered as a candidate gene in innate immunity in dairy sheep [92], also the potential role of this gene was determined in resistance to udder infection in dairy cattle [93]. The DYRK2 gene was associated with milk traits in cattle [94]. Single nucleotide polymorphisms (SNPs) studies in crossbred Bos indicus-Bos taurus cows indicated that this gene has been documented with some role in mammary development [95].…”

Section: Discussionmentioning

confidence: 99%

A meta-analysis of differentially expressed microRNA during mastitis disease in dairy cattle

Panahi,

hasanpour,

ghahramani

et al. 2023

Preprint

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Background: Bovine mastitis is an important inflammation disease that affects the mammary gland and causing adverse effects on the quality and quantity of the produced milk, leads to a major economic lost in dairy industry. Streptococcus uberisis one of the bacteria commonly responsible for inducing mastitis in dairy cattle. Susceptibility to develop mastitis is a complex multifactorial phenotype and the improvement of the miRNAs and their target genes has not been comprehensively illustrated. Methods and Results:The purpose of this investigation was to perform a meta-analysis of the miRNAs expression profiling datasets to detect the key miRNAs, targets, and regulatory networks associated with mastitis. To this, publicly available miRNA datasets belong to three experiments on dairy cattle which challenged with S. uberiswere included in our meta-analyzed. The identified differentially expressed miRNAs were used in TargetScan to identify their target genes. The functional impacts of the meta-miRNAs were further analyzed using Gene ontology and Protein-Protein Interaction network analysis. Three meta-miRNAs, namely bta-miR-98, bta-miR-138 and bta-miR-193a-3p, were obtained to be associated with the progress of the immune system and cell differentiation of the mammary gland during the mastitis. A total of 2061 target genes were identified that which bta-miR-98, bta-miR-138 and bta-miR-193a-3p were regulated 1121, 268 and 672 target genes respectively. Gene ontology analysis results were represented 237 biological process, 41 molecular function, 54 cellular component roles and nine KEGG pathways in mastitis disease. A total of 319, 113 and 124 target genes for bta-miR-98, bta-miR-193a-3p and bta-miR-138, respectively were inputted to cytoscape. The resulted network analysis showed that bta-miR-98 and bta-miR-138 have nine, bta-miR-138 and bta-miR-193a-3p have six, and bta-miR-193a-3p and bta-miR-98 have four common target genes. Twenty-one common genes were revealed by combing 360 common meta-genes in our previous research and 2061 meta-miRNA target genes. The procedure reported in this research offers a comprehensive scheme for the identification of the key miRNAs and target genes in mastitis disease by using global transcriptome data, meta-analysis, gene ontology, enrichment analysis and protein protein interaction. Conclusion: The findings of the current work suggest miRNAs are crucial amplifiers of inflammatory response by controlling metabolic pathway and inhibitors of several biological processes during S. uberis infection.

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Section: Discussionmentioning

confidence: 99%

A meta-analysis of differentially expressed microRNA during mastitis disease in dairy cattle

Panahi,

hasanpour,

ghahramani

et al. 2023

Preprint

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Detection of genetic variation in bovineCRY1gene and its associations with carcass traits

Zhang

et al. 2022

Animal Biotechnology

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Molecular Characterization, Expression Profile, and A 21-bp Indel within the ASB9 Gene and Its Associations with Chicken Production Traits

Qin

Liu

Niu

et al. 2023

Genes

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A growing number of studies have shown that members of the ankyrin repeat and suppressors of cytokine signaling (SOCS) box-containing protein (ASB) family are extensively involved in biological processes such as cell growth, tissue development, insulin signaling, ubiquitination, protein degradation, and skeletal muscle membrane protein formation, while the specific biological role of ankyrin-repeat and SOCS box protein 9 (ASB9) remains unclear. In this study, a 21 bp indel in the intron of ASB9 was identified for the first time in 2641 individuals from 11 different breeds and an F2 resource population, and differences were observed among individuals with different genotypes (II, ID, and DD). An association study of a cross-designed F2 resource population revealed that the 21-bp indel was significantly related to growth and carcass traits. The significantly associated growth traits were body weight (BW) at 4, 6, 8, 10, and 12 weeks of age; sternal length (SL) at 4, 8, and 12 weeks of age; body slope length (BSL) at 4, 8, and 12 weeks of age; shank girth (SG) at 4 and 12 weeks of age; tibia length (TL) at 12 weeks of age; and pelvic width (PW) at 4 weeks of age (p < 0.05). This indel was also significantly correlated with carcass traits including semievisceration weight (SEW), evisceration weight (EW), claw weight (CLW), breast muscle weight (BMW), leg weight (LeW), leg muscle weight (LMW), claw rate (CLR), and shedding weight (ShW) (p < 0.05). In commercial broilers, the II genotype was the dominant genotype and underwent extensive selection. Interestingly, the ASB9 gene was expressed at significantly higher levels in the leg muscles of Arbor Acres broilers than those of Lushi chickens, while the opposite was true for the breast muscles. In summary, the 21-bp indel in the ASB9 gene significantly influenced the expression of the ASB9 gene in muscle tissue and was associated with multiple growth and carcass traits in the F2 resource population. These findings suggested that the 21-bp indel within the ASB9 gene could be used in marker-assisted selection breeding for traits related to chicken growth.

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Determination of genetic variation within the <i>DYRK2</i> gene and its associations with milk traits in cattle

Cited by 3 publications

References 39 publications

A meta-analysis of differentially expressed microRNA during mastitis disease in dairy cattle

A meta-analysis of differentially expressed microRNA during mastitis disease in dairy cattle

Detection of genetic variation in bovineCRY1gene and its associations with carcass traits

Molecular Characterization, Expression Profile, and A 21-bp Indel within the ASB9 Gene and Its Associations with Chicken Production Traits

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