Determination of Free and Conjugated Forms of Endocrine-Disrupting Chemicals in Human Biological Fluids by Gc−MS

Azzouz, Abdelmonaim; Rascón, Andrés J.; Ballesteros, Evaristo

doi:10.4155/bio-2015-0008

Cited by 30 publications

(12 citation statements)

References 35 publications

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“…Several components of these personal care products (PCPs) are classified as known or suspected endocrine disruptors (EDs), i.e., compounds that are able to interfere with the endocrine function in humans and wildlife [2]. EDs are easily absorbed by the skin into the central blood circulation after dermal application, and have been detected in various concentrations in human blood, urine and breastmilk [3]. Concerns have therefore been raised whether extensive use of cosmetics and skincare products could increase the risk of hormone related cancer, for instance breast cancer [4].…”

Section: Introductionmentioning

confidence: 99%

Use of skincare products and risk of cancer of the breast and endometrium: a prospective cohort study

et al. 2019

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BackgroundConcerns have been raised that extensive use of personal care products that contain endocrine disrupting compounds increase the risk of hormone sensitive cancers.ObjectiveTo assess the effect of skincare product use on the risk of pre- and postmenopausal breast cancer, estrogen receptor positive (ER+) and negative (ER-) breast cancer and cancer of the endometrium.MethodsWe used data from 106,978 participants in the population-based Norwegian Women and Cancer cohort. Participants were categorized into non-, light, moderate, frequent and heavy users of skincare products based on self-reported use of hand and facial cream and body lotion. Cancer incidence information from the Cancer Registry of Norway was linked to individual data through the unique identity number of Norwegian citizens. Multivariable Cox proportional hazard regression was used to assess the effect of skincare product use on the risk of cancer of the breast and endometrium. We used multiple imputation by chained equations to evaluate the effect of missing data on observed associations.ResultsWe found no associations between use of skincare products and incidence of premenopausal breast cancer (frequent/heavy versus non−/light use: hazard ratio [HR] =1.10, 95% confidence interval [CI]: 0.92–1.32), postmenopausal breast cancer (heavy versus light use: HR = 0.87, 95% CI: 0.65–1.18, frequent versus light use: HR = 0.97, 95% CI: 0.88, 1.07) or endometrial cancer (frequent/heavy versus non−/light use: HR = 0.97, 95% CI: 0.79–1.20). Use of skincare products did not increase the risk of ER+ or ER- breast cancer and there was no difference in effect across ER status (0.58 ≤ pheterogeneity ≤ 0.99). The magnitude and direction of the effect estimates based on complete case analyses and multiple imputation were similar.ConclusionHeavy use of skincare products, i.e. creaming the body up to two times per day during mid-life, did not increase the risk of cancer of the breast or endometrium.

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Section: Introductionmentioning

confidence: 99%

Use of skincare products and risk of cancer of the breast and endometrium: a prospective cohort study

et al. 2019

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“…Similarly, EtPB concentrations in breast milk from mothers from the Valencian region of Spain ranged between 0.49 and 4.05 ng/mL, which was higher than in other studies (0.6-22 ng/mL) [117]. Only a few studies reported BuPB in human breast milk samples (Table 1) [114,118].…”

Section: Parabensmentioning

confidence: 68%

Environmental Contamination and Human Exposure to Select Endocrine-Disrupting Chemicals: A Review

Seethappan

Vimalkumar

Loganathan

2021

Sustainable Chemistry

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Endocrine-disrupting compounds (EDCs) are exogenous compounds that interfere with the normal hormone functions and ultimately lead to health disorders. Parabens, phenols, and phthalates are well-known EDCs, produced globally in large quantities and widely used in a variety of applications. Several studies have monitored these compounds in a variety of environmental matrices, including air, water, sediment, fish, human tissues, soil, indoor dust, and biosolids, etc. In recent years, environmental contamination and human exposure to these chemicals have become a great concern, due to their residue levels exceeding the permissible/acceptable limits. In this review, we focus on the origin of these EDCs, aquatic contamination pathways, distribution, human exposure, health implications, and healthcare costs. Further, this review identifies critical challenges and future research needs in removing or minimizing environmental contamination and exposure to these chemicals to protect living resources.

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“…BPA is a ubiquitous environmental toxin; it is detectable in the urine samples of most adults and children because it is primarily removed by the kidneys (Doerge et al 2010). Some reports have demonstrated that serum BPA levels are negatively correlated with annual changes in estimated glomerular filtration rates, identifying BPA as a renal damage biomarker (Azzouz et al 2016). Previous studies have also shown that injection of 25 or 50 mg/kg/day of BPA resulted in albuminuria and podocytopenia.…”

Section: Resultsmentioning

confidence: 99%

Effects of short-term exposure to low doses of bisphenol A on cellular senescence in the adult rat kidney

Núñez

Argüelles

Perillán

2023

Histochem Cell Biol

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Bisphenol A (BPA) is one of the primary chemicals produced by volume worldwide. Extensive literature has raised many concerns about its possible involvement in the pathogenesis of kidney diseases, but its contribution has not been extensively studied. During cellular senescence, the interference of lipofuscin with cellular functions promotes further senescence, causing cellular malfunction. Insulin-like growth factor-1 (IGF-1) plays an important protective role in the setting of kidney injury. The goal of the present work was to evaluate the effects of short-term treatment with low doses of BPA on cellular senescence in adult rat kidneys. Male Wistar rats were injected with vehicle (CONTROL group) or 50 or 500 μg/kg/day of BPA for 1 week (BPA50 and BPA500 groups, respectively). The kidneys were fixed in 4% buffered formaldehyde and embedded in paraffin. Immunohistochemical analyses were performed, and an immunoreactive score (IRS) was calculated. Lipofuscin autofluorescence was used for the study of cellular senescence. The renal cortex showed diffuse autofluorescent lipofuscin signal in the proximal convoluted tubules (PCTs) of males in the BPA50-treated (weak intensity) and BPA500-treated (strong intensity) groups, but not in CONTROL males. Labeling of cortical PCTs with anti-IGF-1 antibodies showed an IRS of 0 in the CONTROL group, but IRSs of 4 and 6 in the BPA50- and BPA500-treated groups, respectively. The present results suggest that low, “safe” doses of BPA induce renal injury, as measured by histological signs of renal changes, increased cellular senescence, and activation of cellular repair systems in PCTs.

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Determination of Free and Conjugated Forms of Endocrine-Disrupting Chemicals in Human Biological Fluids by Gc−MS

Abstract: This allowed its successful application to the determination of EDCs in human urine, blood and breast milk. The most frequently founded were methylparaben, ethylparaben, bisphenol A and triclosan.

Cited by 30 publications

References 35 publications

Use of skincare products and risk of cancer of the breast and endometrium: a prospective cohort study

Use of skincare products and risk of cancer of the breast and endometrium: a prospective cohort study

Environmental Contamination and Human Exposure to Select Endocrine-Disrupting Chemicals: A Review

Effects of short-term exposure to low doses of bisphenol A on cellular senescence in the adult rat kidney

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