Determination of four thiophenethylamine designer drugs (2C-T-series) in human plasma by capillary electrophoresis with mass spectrometry detection

Boatto, Gianpiero; Nieddu, Maria; Dessì, Giorgia; Manconi, Paola Maria; Cerri, Riccardo

doi:10.1016/j.chroma.2006.10.051

Cited by 36 publications

(25 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To date, the determination of amphetamines from the ALEPH series in biological samples has not yet been demonstrated. However, capillary electrophoresis has recently been applied to the detection in biological matrices of phenethylamine‐based analogues of ALEPH‐2 (2C‐T‐series) 11, 12. Analysis by capillary electrophoresis/mass spectrometry (CE/MS) does not require sample derivatisation prior to analysis to improve the sensitivity of the method and it has been successfully applied to a wide variety of small molecules in biological matrices, including amphetamine‐like compounds 13–16…”

mentioning

confidence: 99%

Simultaneous determination of new thioamphetamine designer drugs in plasma by capillary electrophoresis coupled with mass spectrometry

Boatto

Nieddu

Pirisi

et al. 2007

Rapid Comm Mass Spectrometry

Self Cite

View full text Add to dashboard Cite

A simple method for the simultaneous identification and quantification of four 2,5-methylenedioxy derivatives of 4-thioamphetamine (ALEPH series) in plasma samples was developed. The method consists of solid-phase extraction (SPE) using a Bond Elut C(18) cartridge and capillary electrophoresis coupled with electrospray ionisation mass spectrometry (CE/ESI-MS). The SPE method used required only simple steps and provided a clean extract from which identification of each drug was feasible, even at low concentrations. The method was validated according to international guidelines. The calibration curves were linear over the concentration range of 50 to 1000 ng/mL for all drugs with correlation coefficients that exceeded 0.998. The lower limits of detection of the drugs were 23-43 ng/mL. The absolute recoveries for the drugs were 64-92% and 75-96% at concentrations of 100 and 500 ng/mL, respectively. The validation data (precision, accuracy, and recovery) show the reproducibility and selectivity of the method. This clean and simple method allows the routine detection of designer drugs such as thioamphetamines which may become a serious problem in the control of illegal drugs.

show abstract

mentioning

confidence: 99%

Simultaneous determination of new thioamphetamine designer drugs in plasma by capillary electrophoresis coupled with mass spectrometry

Boatto

Nieddu

Pirisi

et al. 2007

Rapid Comm Mass Spectrometry

Self Cite

View full text Add to dashboard Cite

show abstract

“…Different approaches exist for the determination of LODs. In this study, LODs were estimated from calibration curves obtained during the linearity assay . Alternatively, these data could be obtained experimentally using standard solutions; S/N ratios ∼3 and percent RSD cut‐off of roughly 20% are commonly used as specifications.…”

Section: Resultsmentioning

confidence: 99%

Identification and quantification of bisphenol A and bisphenol B in polyvinylchloride and polycarbonate medical devices by gas chromatography with mass spectrometry

Gimeno

Spinau

Lassu

et al. 2015

J of Separation Science

View full text Add to dashboard Cite

A gas chromatography with mass spectrometry method has already been developed and published for the identification and quantification of 14 phthalates and five nonphthalate plasticizers in polyvinylchloride medical devices. In order to assay, in addition to plasticizers, bisphenols A and B possibly present in polyvinylchloride samples, this previous method was extended to the assay of these additional potential endocrine disruptors. Furthermore, as bisphenol A could also be present in polycarbonate samples, the method used for the polyvinylchloride sample was tested and validated for the assay of bisphenols A and B in polycarbonate medical devices. The separation of all compounds, including bisphenols A and B, is obtained on a cross-linked 5%-phenyl/95%-dimethylpolysiloxane capillary column using a temperature gradient. For both plastics, samples are dissolved in tetrahydrofuran followed by a precipitation of the plastic by addition of ethanol. Results obtained point out residual bisphenol A amounts for polycarbonate samples ranging from 0.6 to 0.8% and for polyvinylchloride samples less or equal to 5 ppm. No bisphenol B was detected in the samples tested. For bisphenols A and B, mean recoveries obtained on spiked polyvinylchloride or polycarbonate sample preparations ranged from 87 to 108% in accordance with in-house specification (80-110%).

show abstract

“…Many diff erent techniques have been developed to screen for these newer designer drugs, including capillary electrophoresismass spectrometry (9)(10)(11)(12), capillary electrophoresis coupled with a diode array detector (13), gas chromatography-mass spectrometry (14,15), and liquid chromatography-mass spectrometry (LC-MS) (16). In more recent years, LC-MS in tandem (LC-MS/MS) has become the detection test of choice due to its ability to separate and identify small molecules with similar structures in one run (17).…”

Section: Discussionmentioning

confidence: 99%

Identification of Designer Drug 2C-E (4-Ethyl-2, 5-Dimethoxyphenethylamine) in Urine Following a Drug Overdose

Vrancken

Benavides²,

Wians³

2013

Baylor University Medical Center Proceedings

View full text Add to dashboard Cite

Determination of four thiophenethylamine designer drugs (2C-T-series) in human plasma by capillary electrophoresis with mass spectrometry detection

Cited by 36 publications

References 20 publications

Simultaneous determination of new thioamphetamine designer drugs in plasma by capillary electrophoresis coupled with mass spectrometry

Simultaneous determination of new thioamphetamine designer drugs in plasma by capillary electrophoresis coupled with mass spectrometry

Identification and quantification of bisphenol A and bisphenol B in polyvinylchloride and polycarbonate medical devices by gas chromatography with mass spectrometry

Identification of Designer Drug 2C-E (4-Ethyl-2, 5-Dimethoxyphenethylamine) in Urine Following a Drug Overdose

Contact Info

Product

Resources

About