Determination of fluvoxamine maleate in human urine and human serum using alkaline KMnO₄–rhodamine B chemiluminescence

Abstract

The flow-injection chemiluminescence (FI-CL) behavior of a gold nanocluster (Au NC)-enhanced rhodamine B-KMnO system was studied under alkaline conditions for the first time. In the present study, the as-prepared bovine serum albumin-stabilized Au NCs showed excellent stability and reproducibility. The addition of trace levels of fluvoxamine maleate (Flu) led to an obvious decline in CL intensity in the rhodamine B-KMnO -Au NCs system, which could be used for quantitative detection of Flu. Under optimized conditions, the proposed CL system exhibited a favorable analytical performance for Flu determination in the range 2 to 100 μg ml . The detection limit for Flu measurement was 0.021 μg ml . Moreover, this newly developed system revealed outstanding selectivity for Flu detection when compared with a multitude of other species, such as the usual ions, uric acid and a section of hydroxy compounds. Additionally, CL spectra, UV-visible spectroscopes and fluorescence spectra were measured in order to determine the possible reaction mechanism. This approach could be used to detect Flu in human urine and human serum samples with the desired recoveries and could have promising application under physiological conditions.

Ultrasensitive chemiluminescence assay for cimetidine detection based on the synergistic improving effect of Au nanoclusters and graphene quantum dots

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Therapeutic Drug Monitoring in Psychiatry: Enhancing Treatment Precision and Patient Outcomes

“…Oral fluid microsampling also gave satisfying results in the monitoring of sertraline, fluoxetine, citalopram, and vortioxetine [153]. Urine can be used as a matrix for monitoring escitalopram, citalopram, fluoxetine, paroxetine, and bupropion, and it has also been proposed for the monitorization of fluvoxamine and moclobemide [154][155][156][157][158][159][160][161]. For TCAs, urine sampling can be used, even though mostly for forensic studies rather than for routinary monitoring [162].…”

Aggregation-induced emission materials: a platform for diverse energy transformation and applications

“…72 A CRET system usually consists of chemiluminescence (CL) donors ( e.g. , peroxyoxalate, 73,74 lucigenin, 75–77 luminol, 78–80 KMnO 4 , 81 etc .) and suitable acceptors ( e.g.…”