Determination of fluoroquinolone antibiotics in hospital and municipal wastewaters in Coimbra by liquid chromatography with a monolithic column and fluorescence detection

Seifrtová, Martina; Pena, Angelina; Lino, Celeste M.; Solich, Petr

doi:10.1007/s00216-008-2020-1

Cited by 164 publications

(115 citation statements)

References 28 publications

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“…LC-MS/MS is indicated as the technique of choice to assay relatively polar pharmaceuticals and their metabolites as it is especially suitable for the environmental analysis because of its selectivity comparing to UV [11,36] or FD [50,53,57].…”

Section: Methodsmentioning

confidence: 99%

“…The mostly used SPE cartridges were polymeric Oasis HBL [50,53,54]. However, other types including cation-exchange [51,52], C 18 [36] and Chromabond tetracycline [55] were used.…”

Section: Quinolone Antibioticsmentioning

confidence: 99%

“…However, other types including cation-exchange [51,52], C 18 [36] and Chromabond tetracycline [55] were used. A tandem system using an anion-exchange cartridge on the top together with Oasis HLB was also described [53]. The anion-exchange column was used for pre-purification since humic acids and others impurities were retained.…”

Section: Quinolone Antibioticsmentioning

confidence: 99%

“…LC coupled to tandem MS method is nowadays a technique of choice for the determination of very low concentrations of FQs in environmental waters because of its selectivity and specificity. However, LC with FD was used in six works [50][51][52][53][54][55]. FQs are naturally highly fluorescent compounds and RP-LC-FD can be used for their determination.…”

Section: Fluoroquinolone Antibioticsmentioning

confidence: 99%

“…However, RP-amide C 16 stationary phase [51] and C 8 analytical column were utilized [35,50,52]. A monolithic column was used for LC separation in two studies [53,54]. In four studies the separation was performed using gradient elution [36,50,51,55] and in four studies by isocratic elution [35,[52][53][54].…”

Section: Fluoroquinolone Antibioticsmentioning

confidence: 99%

See 4 more Smart Citations

An overview of analytical methodologies for the determination of antibiotics in environmental waters

Seifrtová¹,

Nováková²,

Lino³

et al. 2009

Analytica Chimica Acta

313

170

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a b s t r a c tThe widespread occurrence of antibiotics as contaminants in the aquatic environment has increased attention in the last years. The concern over the release of antibiotics into the environment is related primarily to the potential for the development of antimicrobial resistance among microorganisms. This article presents an overview of analytical methodologies for the determination of quinolone (Qs) and fluoroquinolone (FQs), macrolide (MLs), tetracycline (TCs), sulfonamide (SAs) antibiotics and trimethoprim (TMP) in different environmental waters. The analysis of these antibiotics has usually been carried out by high-performance liquid chromatography (HPLC) coupled to mass spectrometry (MS) or tandem mass spectrometry (MS/MS) and to a lesser extent by ultraviolet (UV) or fluorescence detection (FD). A very important step before LC analysis is sample preparation and extraction leading to elimination of interferences and prevention of matrix effect and preconcentration of target analytes.

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Section: Methodsmentioning

confidence: 99%

“…The mostly used SPE cartridges were polymeric Oasis HBL [50,53,54]. However, other types including cation-exchange [51,52], C 18 [36] and Chromabond tetracycline [55] were used.…”

Section: Quinolone Antibioticsmentioning

confidence: 99%

Section: Quinolone Antibioticsmentioning

confidence: 99%

Section: Fluoroquinolone Antibioticsmentioning

confidence: 99%

Section: Fluoroquinolone Antibioticsmentioning

confidence: 99%

See 3 more Smart Citations

An overview of analytical methodologies for the determination of antibiotics in environmental waters

Seifrtová¹,

Nováková²,

Lino³

et al. 2009

Analytica Chimica Acta

313

170

View full text Add to dashboard Cite

show abstract

Solid‐Phase Extraction and Clean‐Up Procedures in Pharmaceutical Analysis

Campíns‐Falcó

Herráez‐Hernández

Molíns-Legua

et al. 2022

Encyclopedia of Analytical Chemistry

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Solid‐phase extraction (SPE) using small cartridges filled with sorbents of a small particle size has rapidly established itself as an important sample clean‐up technique since the 1980s. It has prospered at the expense of traditional liquid–liquid extraction (LLE) which is considered labor‐intensive and frequently plagued by problems, such as emulsion formation and use of large volumes of hazardous solvents. A remarkable characteristic of SPE is its easy adaptation to on‐line mode by column switching techniques; switching can be affected manually or by automated controllers. The same analyte/sorbent interactions that are exploited in liquid chromatography (LC) are of use in SPE, but particle sizes employed are generally greater. Chemically bonded silica (SI), usually with C 18 and C 8 organic groups, is by far the most commonly used material. Cross‐linked polystyrene and other polymeric resins and mixed‐mode SPE sorbents are also widely used. Recently, different sorbents have been introduced in order to improve the selectivity such as molecularly imprinted polymers (MIPs) and immunoaffinity sorbents or to improve the extraction capacity through the increment of the surface‐to‐volume ratio (i.e. hypercross‐linked resins). Advances in material science in general and in nanomaterials in particular mark a trend in this field. Also, ionic liquids (ILs), carbon‐based materials, sol‐gel‐based compounds, and metal‐organic frameworks (MOFs), among others, are being introduced. Current trends in SPE are aimed toward the development of miniaturized systems which facilitate its automation and increase its precision, throughput, and cost‐effectiveness. Its compatibility with the goals of sustainable chemistry is remarkable. Examples of such trends are the new formats of SPE such as solid‐phase microextraction (SPME) including in‐tube solid‐phase microextraction (IT‐SPME) and tip‐based microextraction, between other formats. There are different approaches to automation for both off‐line and on‐line SPE, which involve different levels of apparatus cost. SPE is generally easier and cheaper than LLE for achieving this last goal. The precision obtained is similar for both techniques, while the recoveries obtained by SPE are generally better than those obtained by LLE. Enrichment, derivatization, and fractionation can also be carried out by use of SPE sorbents as supports.

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Removal of Contaminants of Emerging Concern from Wastewater

Dosoretz

2019

Encyclopedia of Water

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Increased awareness regarding water pollution and resources conservation due to water scarcity and climate change, combined with intensive urbanization and agricultural production, have raised the need for removal of contaminants of emerging concern (CEC) from treated effluents. CEC include, among others, pharmaceuticals, cleaning and sanitation products, endocrine disrupting compounds, suspected carcinogens, and nanomaterials at trace concentration. Added to this are antibiotic‐resistant bacteria (ARB) and antibiotic‐resistant genes (ARG). Conventional wastewater treatment removes bulk organic contaminants leaving CEC in the effluents. This article discusses the incorporation of advanced treatments such as oxidation processes, adsorption, and tight membrane separation, i.e. reverse osmosis (RO), aimed at removing CEC from effluents. Owing to its generic capability to remove dissolved organic and inorganic contaminants at once, RO appears as the core technology for effluents purification. Besides improvements of existing municipal effluents, changes in conception, management and planning of the urban water systems, e.g. reduction at source and decentralization approaches, are required. Removal of dissolved organic pollutants and mineral contaminants at trace levels cannot be done without consuming energy. The water–energy nexus and related life cycle analyses need to be rethought in terms of environmental and health risks and deterioration of water resources and soils.

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Determination of fluoroquinolone antibiotics in hospital and municipal wastewaters in Coimbra by liquid chromatography with a monolithic column and fluorescence detection

Cited by 164 publications

References 28 publications

An overview of analytical methodologies for the determination of antibiotics in environmental waters

An overview of analytical methodologies for the determination of antibiotics in environmental waters

Solid‐Phase Extraction and Clean‐Up Procedures in Pharmaceutical Analysis

Removal of Contaminants of Emerging Concern from Wastewater

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