On the other hand, the hardware controlled titrator, while less versatile and less accurate than the computerized titrator, is much simpler and less expensive. It is particularly well suited to routine applications where relative standard deviations of the order of 0.4% are adequate. The titrant delivery device could also be modified to produce smaller droplets of titrant (3). This would enable titration of very small samples, such as single cells, provided that suitable micromonitors are available.
ACKNOWLEDGMENTThe authors express their appreciation to Maurice Williams and Larry Sexton for their help in construction of some of the apparatus used in this study. Thanks are also due to B. M. Mandarano, who performed some of the first fixed-level titrations with the reported titrator.