Determination of finasteride in the tablet form by liquid chromatography and its analytical method validation

Advances in the analysis of steroid hormone drugs in pharmaceuticals and environmental samples (2004–2010)

“…These stability-indicating methods are almost exclusively RP-HPLC methods with UV detection. The determination of betamethasone [67], betamethasone dipropionate [68], budesonide [69], clobetasol propionate [70], deflazacort [71], dexamethasone [71][72][73][74], dexamethasone acetate [75], dexamethasone sodium phosphate [72,76], diflucortolone valerate [77], dutasteride [19], eplerenone [18], estradiol [21,78,79], ethinylestradiol [80], fluocinolone acetonide [81], finasteride [82], fluticasone propionate [83], gestodene [80], medroxyprogesterone acetate [14], meprednisone [84], mometasone furoate [85], testosterone propionate and cypionate [86] and triamcinolone acetonide [87] in various solid, semi-solid and liquid formulations have been described. The on-line assay of beclomethasone propionate pressurized metered dose inhalers [88] and the determination of the solubility of beclomethasone propionate [89] and budesonide [90] in the same device are also worth mentioning.…”

Application of 2-Chloro-7-Nitrobenzo-2-Oxa-1, 3-Diazol (NBDCL) for Spectrophotometric Determination of Finasteride in Pharmaceutical Formulation

“…It's widely used for the treatment of benign prostatic hyperplasia (BPH), prostate cancer, and androgenetic alopecia [2][3][4][5][6][7]. Literature survey reveals that various methods have been reported for the analysis of finasteride in pharmaceutical preparations and biological samples such as gas-chromatography (GC) [9], and (GC-MS) [10] High Performance Liquid Chromatography (HPLC) with various detectors [11][12][13], polarography [14], voltammetry [15] and spectrophotometry [16][17][18].…”

The Determinatıon of The Stability Constant of Finasteride Complexes with Various Metals by Potentiometric and Spectrophotometric Methods

“…Finasteride is being accepted as the most efficient cure in the whole World, to the hair loss related with dHt. The literature research showed that several methods for determination of finasteride in the pharmaceutical preparations and biological fluids including highperformance liquid chromatography (HPlC) [5][6][7], liquid chromatography tandem-mass spectrometry (lC-MS) [8][9][10][11], gas chromatography (GC) [12], ultra-performance liquid chromatography (uPlC-MS) [13], spectrophotometry [14], voltametry [15] and polarography [16] have been developed. Because most drugs are weak acids or bases, information about their ionization at physiological pH values carry important information related to the behavior of drugs in penetrating different parts of the body.…”