Determination of ferric iron chelators by high-performance liquid chromatography using luminol chemiluminescence detection

Ariga, Tomoko; Imura, Yoshimi; Suzuki, Michio; Yoshimura, Etsuro

doi:10.1016/j.jchromb.2016.01.048

Cited by 7 publications

(3 citation statements)

References 31 publications

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“…56,57 A concentration of 8 × 10 −3 M H 2 O 2 was similarly established by volumetric additions of aqueous H 2 O 2 . This concentration of H 2 O 2 is similar to values reported during similar work and was found empirically to produce optimal ECL light intensity 40,56,[58][59][60] All solutions containing H 2 O 2 were used within 12 hours of preparation.…”

Section: Methodssupporting

confidence: 76%

The Study of AA2024 De-Alloying Using Luminol Electrogenerated Chemiluminescence Imaging

Wint

Barrett

Williams

et al. 2019

J. Electrochem. Soc.

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This paper describes the use of luminol electrogenerated chemiluminescence (ECL) to image the redistribution of electrochemically active copper (copper in electrical contact with the substrate) at the surface of AA2024-T351 corroding in NaCl electrolyte. AA2024 samples are thermo-mechanically treated to produce a macroscopically inhomogeneous distribution of intermetallic particles. The AA2024-T351 samples are allowed to corrode by immersion in 0.51 M aqueous NaCl and (ex-situ) ECL measurements are performed to follow copper redistribution. Luminol ECL light emission is orders of magnitude more intense on copper than aluminum and macro and microscopic images are obtained to elucidate the redistribution of electrochemically active copper. S phase de-alloying produces a radical redistribution of copper on a microstructural scale (1-10 μm) but macroscopic copper distributions (1-10 mm) remain largely unchanged. In-situ experiments using the SVET show that macroscopic copper distribution directs localization of corrosive attack such that net anodic activity (pitting/intergranular attack) is concentrated in regions with lowest surface coverage of copper and net cathodic activity is concentrated in regions of highest coverage. Results are explained in terms of the role of solution chemistry and pH in influencing the transition from transient to stable pitting.

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Section: Methodssupporting

confidence: 76%

The Study of AA2024 De-Alloying Using Luminol Electrogenerated Chemiluminescence Imaging

Wint

Barrett

Williams

et al. 2019

J. Electrochem. Soc.

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“…There is no method available for combined determination with the presence of CMN. Many analytical techniques are available for individual analysis of BA. − EDTA is a UV inactive component, and few authors made the analyte UV active by a derivatization process and determined by using different techniques. − Several kinds of literature are available for the CMN content determination in different formulations. − Two reports are available to determine EDTA and BA by HPLC and MS analyses. , …”

Section: Introductionmentioning

confidence: 99%

Green Chromatographic Method for Determination of Active Pharmaceutical Ingredient, Preservative, and Antioxidant in an Injectable Formulation: Robustness by Design Expert

Kowtharapu

Katari

Sandoval³

et al. 2022

ACS Omega

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We report an efficient HPLC method for simultaneous qualitative and quantitative analysis of lincosamide antibiotic injectable formulations containing Clindamycin phosphate (CMN), benzyl alcohol (BA), and ethylenediaminetetraacetic acid (EDTA) as major ingredients. The three components were separated by Phenomenex prodigy C8 (250 mm × 4.6 mm, 5 μm) HPLC column, flow rate 1.1 mL/min, injection volume 30 μL, and column temperature 35 °C, using 0.05 M sodium acetate buffer (pH 4.5) with acetonitrile (ACN) in the ratio of 80:20 (v/v). The detection wavelength was set as 240 nm. The method was validated as per International Conference on Harmonization (ICH) guidelines and was confirmed to be specific, precise, accurate, and linear. Method robustness was executed by utilizing quality in the design of the experiment. Accuracy results were found to be 99.3–100.5% for CMN, 99.3–100.8% for BA, and 99.1–100.3% for EDTA. Precision results were obtained as % relative standard deviation (RSD): 0.6% for CMN, 0.4% for BA, and 0.4% for EDTA. Correlation coefficient ( r 2 ) values were obtained as >0.999 for the three components. Analytical solutions are stable for 48 h at benchtop and refrigerator conditions. The greenness of the analytical method was evaluated by the Green Analytical Procedure Index (GAPI), National Environmental Method Index (NEMI), analytical eco-scale, and Analytical Greenness (AGREE) tools to confirm that the method is eco-friendly.

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“…Today, different methods are used to measure iron ions, for example, inductively coupled plasma-mass spectrometry, neutron activation analysis, atomic absorption spectrometry (AAS), highperformance liquid chromatography (HPLC), flow injection and fluorimetry [10][11][12][13][14][15]. Most these methods require several time-consuming manipulation steps, expensive devices and specialists to operate or data processing.…”

Section: Introductionmentioning

confidence: 99%

A Novel Iron(III) Potentiometric Sensor Based on (E)-N'-((2-hydroxynaphthalen-3-yl)methylene)benzohydrazide

Yari¹

2016

International Journal of Electrochemical Science

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Here, we report the design and application of a new PVC membrane electrode, based on (E)-N'-((2-hydroxynaphthalen-3-yl)methylene)benzohydrazide as a reliable complexing agent, for determination of iron(III) ion. The electrode illustrates an excellent Nernstian slope of 19.9±0.3 mV/decade over a wide linear range of concentration from 5.0×10 -9 to 1.0×10 -2 M with a detection limit of 1.0×10 -9 M of Fe 3+ in solution. The tolerable pH range of 2.4 to 4.0, response time of 10 s and measurement stability for 3 months is valuable characteristics of the sensor. The analytical application of the sensor was successfully tested by potentiometric titration of a Fe(III) solution with EDTA in some water samples. The accuracy of given measuring data was tested by determination of Fe 3+ in some water solutions from different resources with both the sensor and an atomic absorption spectrometer, as a standard method. The results were well comparable. We inform a reliable device that provides a simple method to determine Fe 3+ ion in a fast manner with high accuracy.

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Determination of ferric iron chelators by high-performance liquid chromatography using luminol chemiluminescence detection

Cited by 7 publications

References 31 publications

The Study of AA2024 De-Alloying Using Luminol Electrogenerated Chemiluminescence Imaging

The Study of AA2024 De-Alloying Using Luminol Electrogenerated Chemiluminescence Imaging

Green Chromatographic Method for Determination of Active Pharmaceutical Ingredient, Preservative, and Antioxidant in an Injectable Formulation: Robustness by Design Expert

A Novel Iron(III) Potentiometric Sensor Based on (E)-N'-((2-hydroxynaphthalen-3-yl)methylene)benzohydrazide

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