Determination of Factors of the Plasma Kinin System in Plasma Substrate Specimens From Patients With Specific, Exogenous Allergies

Assay of Factors of the Kinin System in Plasma From Patients With Specific, Exogenous Allergies

“…Among the various "allergic" syndromes with asthma as the predominating symptom, patients with "specific, exogenous allergy" of the immediate (or anaphylactoid) reaction type, constitute the best-defined and most homogeneous group. The patient material, all males, was selected to correspond roughly with that of a previous investigation (2). Some of the characteristics of the cases are summarized in Table i.…”

“…It has previously been reported that the amounts of kinin released by submaximum concentrations of hog pancreas kallikrein or by acetone-activated human plasma were lower in plasma specimens from patients with allergies than in plasma specimens from healthy subjects. At the same time, the initial rate of kinin release was higher in plasma from the patients than in plasma from the control group (2). It was suggested that the lower degree of kinin release in plasma from the allergic individuals might be due to an increased level of kallikrein inhibitor.…”