Determination of Ethambutol in Aqueous Medium Using an Inexpensive Gold Microelectrode Array as Amperometric Sensor

Lima, Aline Estefany Brandão; Luz, Geraldo E.; Batista, N. C.; Longo, Elson; Cavalcante, L. S.; Santos, Reginaldo da Silva

doi:10.1002/elan.201500600

Cited by 10 publications

(7 citation statements)

References 33 publications

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“…Figure 8 shows a serie of cyclic voltammograms of a 0.14 mg/μL ETB solution at scan rates from 0.01 to 0.2 V·s −1 in CPBS pH 7.4. Cyclic voltammograms of the drug gave one well-defined anodic peak that from comparison with the literature can be ascribed to the oxidation of the alcohol moieties of the ETB molecule [ 45 ]. There is no peak on the reverse scan, indicating the irreversibility of the process.…”

Section: Resultsmentioning

confidence: 99%

“…Very few works reporting the electrochemical determination of ETB have been published. Among them, Lima et al proposed a gold-microelectrode array with a LOD of 1.55 × 10 −4 mM, which was only applied to aqueous solutions [ 45 ]. Shao et al applied a MWCNT modified glassy carbon electrode to the detection of this drug in pharmaceutical formulations with a LOD of 7.6 × 10 −4 mM [ 46 ].…”

Section: Resultsmentioning

confidence: 99%

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Development of a Nafion/MWCNT-SPCE-Based Portable Sensor for the Voltammetric Analysis of the Anti-Tuberculosis Drug Ethambutol

Couto

Quinaz

2016

Sensors

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Herein we describe the development, characterization and application of an electrochemical sensor based on the use of Nafion/MWCNT-modified screen-printed carbon electrodes (SPCEs) for the voltammetric detection of the anti-tuberculosis (anti-TB) drug ethambutol (ETB). The electrochemical behaviour of the drug at the surface of the developed Nafion/MWCNT-SPCEs was studied through cyclic voltammetry (CV) and square wave voltammetry (SWV) techniques. Electrochemical impedance spectroscopy (EIS) and scanning electron microscopy (SEM) were employed to characterize the modified surface of the electrodes. Results showed that, compared to both unmodified and MWCNTs-modified SPCEs, negatively charged Nafion/MWCNT-SPCEs remarkably enhanced the electrochemical sensitivity and selectivity for ETB due to the synergistic effect of the electrostatic interaction between cationic ETB molecules and negatively charged Nafion polymer and the inherent electrocatalytic properties of both MWCNTs and Nafion. Nafion/MWCNT-SPCEs provided excellent biocompatibility, good electrical conductivity, low electrochemical interferences and a high signal-to-noise ratio, providing excellent performance towards ETB quantification in microvolumes of human urine and human blood serum samples. The outcomes of this paper confirm that the Nafion/MWCNT-SPCE-based device could be a potential candidate for the development of a low-cost, yet reliable and efficient electrochemical portable sensor for the low-level detection of this antimycobacterial drug in biological samples.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Development of a Nafion/MWCNT-SPCE-Based Portable Sensor for the Voltammetric Analysis of the Anti-Tuberculosis Drug Ethambutol

Couto

Quinaz

2016

Sensors

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“…The acceptable recoveries were noted for the detection of ETB and PZM. The developed IL@CoFe 2 O 4 NPs@MWCNTs@GCE sensor might be competent in the detection of ETB and PZM in more commercial pharmaceuticals compared to that of other related techniques 16,[33][34][35][36][37][38][39][40][41][42][43][44] .…”

Section: Real Sample Analysismentioning

confidence: 99%

Simultaneous detection of ethambutol and pyrazinamide with IL@CoFe2O4NPs@MWCNTs fabricated glassy carbon electrode

Chokkareddy

Kanchi

Inamuddin

2020

Sci Rep

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For the first time, we report a novel electrochemical sensor for the simultaneous detection of ethambutol (ETB) and pyrazinamide (PZM) using 1-ethyl-3-methylimidazolium tetrafluoroborate ([emim][Bf 4 ]) ionic liquid (iL) assimilated with multiwalled carbon nanotubes (MWcnts) decorated cobalt ferrite nanoparticles (cofe 2 o 4 nps) on the surface of glassy carbon electrode (Gce). the surface morphological and electrochemical properties of the iL@cofe 2 o 4 nps@MWcnts was characterized with X-ray diffraction (XRD), transmission electron microscope (TEM), thermogravimetric analysis (TGA), fourier transform infrared spectroscopy (FTIR) and cyclic voltammetry (CV), differential pulse voltammetry (DPV) respectively. Moreover, the obtained results of CV demonstrated that the 9-folds enhancement in the electrochemical signals was achieved with iL@cofe 2 o 4 nps@MWcnts@Gce compared to that of a bare Gce. Additionally, the simultaneous electrochemical detection of etB and pZM was successfully accomplished using iL@cofe 2 o 4 NPs@MWCNTs over a wide-range of concentration with good limit of detection (3S/m) of 0.0201 and 0.010 μM respectively. The findings of this study identify iL@cofe 2 o 4 nps@MWcnts@Gce has promising abilities of simultaneous detection of etB and pZM in pharmaceutical formulations.

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“…Therefore, it is very important to develop a simple, sensitive, reliable and environmentally friendly method for the determination of ethambutol. Several analytical techniques were reported including, potentiometry, Fourier-transform infrared spectroscopy, ultraviolet spectroscopy, fluorescence spectroscopy, capillary electrophoresis, supercritical fluid chromatography, mass spectrometry, high performance liquid chromatography and electroanalytical methods [5,7,[9][10][11][12][13]. However, attention has been given to electrochemical techniques recently owing to their operational simplicity, sensitivity, cost effectiveness, absence of extensive sample pretreatment and suitability for onsite analysis due to their portability.…”

Section: Introductionmentioning

confidence: 99%

Sensitive electrochemical determination of ethambutol in pharmaceutical formulation and human urine at nickel nanoparticles/electrochemically reduced graphene oxide modified electrode

Mekassa¹,

Baker²,

Chandravanshi³

et al. 2019

Bull. Chem. Soc. Eth.

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This paper describes the application of nickel nanoparticles decorated electrochemically reduced graphene oxide modified glassy carbon electrode (NiNPs/ERGO/GCE) for the determination of ethambutol (ETB), an anti-Mycobacterium tuberculosis drug. The modified electrode showed remarkable electrocatalytic properties accompanied with a significant enhancement in the peak current response towards ETB compared to the bare electrode. The results showed that the composite modified electrode played a significant catalytic role due to the synergetic effect of NiNPs and ERGO. The NiNPs/ERGO modified electrode demonstrated excellent square wave voltammetric response towards ETB determination at the NiNPs/ERGO/GCE in the range 0.05-100 µM. The sensor demonstrated outstanding sensitivity towards ETB determination with limit of detection (LOD) and limit of quantification (LOQ) of 0.023 and 0.075 µM, respectively. The developed sensor was effectively validated for real sample study using drug formulation and urine samples which showed an acceptable recovery (99.6-109%). The electrode also exhibited good precision (RSD < 1%, n = 20), reproducibility (RSD < 1.9%, n = 3), long-term stability (92% of its initial response after two weeks) and selectivity towards interfering substances in the determination of ethambutol.

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Determination of Ethambutol in Aqueous Medium Using an Inexpensive Gold Microelectrode Array as Amperometric Sensor

Cited by 10 publications

References 33 publications

Development of a Nafion/MWCNT-SPCE-Based Portable Sensor for the Voltammetric Analysis of the Anti-Tuberculosis Drug Ethambutol

Development of a Nafion/MWCNT-SPCE-Based Portable Sensor for the Voltammetric Analysis of the Anti-Tuberculosis Drug Ethambutol

Simultaneous detection of ethambutol and pyrazinamide with IL@CoFe2O4NPs@MWCNTs fabricated glassy carbon electrode

Sensitive electrochemical determination of ethambutol in pharmaceutical formulation and human urine at nickel nanoparticles/electrochemically reduced graphene oxide modified electrode

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