Determination of endocrine-disrupting potencies of agricultural soils in China via a battery of steroid receptor bioassays

Zhang, Jianyun; Li, Rui; Niu, Lili; Zhu, Siyu; Zhang, Quan; Zhao, Meirong; Liu, Weiping; Liu, Jing

doi:10.1016/j.envpol.2017.12.004

Cited by 25 publications

(9 citation statements)

References 34 publications

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“…According to Zhang et al. soil exposed with organochlorine pesticides has an endocrine disrupting potential ( Zhang et al., 2018 ). The lack of information on the fate and potential toxicity of such pollutants make it difficult for regulatory authorities to manage these contaminants.…”

Section: Introductionmentioning

confidence: 99%

“…These hazardous wastes have the potential to bind to DNA and produce negative alterations in biological processes such as cytotoxicity, cancer, altered metabolism, and reproductive failure (Du et al, 2020;Singh and Chandra, 2019;Zhao et al, 2019). According to Zhang et al soil exposed with organochlorine pesticides has an endocrine disrupting potential (Zhang et al, 2018). The lack of information on the fate and potential toxicity of such pollutants make it difficult for regulatory authorities to manage these contaminants.…”

Section: Introductionmentioning

confidence: 99%

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Genotoxic hazard and oxidative stress induced by wastewater irrigated soil with special reference to pesticides and heavy metal pollution

Zeyad

Khan

Malik

2022

Heliyon

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Genotoxic hazard and oxidative stress induced by wastewater irrigated soil with special reference to pesticides and heavy metal pollution

Zeyad

Khan

Malik

2022

Heliyon

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“…These hazardous waste can bind to DNA and cause harmful changes in cellular process such as cytotoxicity, carcinogenesis, enzyme function, impaired metabolism and reproductive dysfunctioning [17][18][19] . Several studies have shown that pesticides contamination in soil pose a potential risk to environment and human health [20][21][22] . The lack of information on the fate and potential toxicity of such pollutants make it di cult for regulatory authorities to manage these contaminants.…”

Section: Introductionmentioning

confidence: 99%

Genotoxic Hazard and Oxidative Stress Induced by Wastewater Irrigated Soil With Special Reference to Pesticides and Heavy Metal Pollution

Zeyad

Malik

2021

Preprint

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Enhancement of industrial growth and urbanization, soil contamination is increasingly prominent. Therefore, it’s important to examine possible adverse effects of industrial waste. Samples were found to be polluted with several heavy-metals and pesticides. Gas chromatographic results showed occurrence of high-level of organochlorine and organophosphate pesticides. Genotoxicity of soil extracts was assessed using environmental-risk assessment models. Soil samples were extracted in hexane and dichloromethane solvents and were evaluated for genotoxic potential by prokaryotic (Ames test, plasmid nicking assay and E. coli K-12 DNA repair defective mutants) and eukaryotic (Allium cepa root chromosomal aberration and Vigna radiata seed-germination test) bioassays. Strain TA98 was found most susceptible among soil extracts. Hexane soil extract of wastewater irrigation was determined more mutagenic than DCM samples in terms of mutagenic index, mutagenic potential and induction factor for Ames strains. The damage in DNA repair defective mutants of hexane extracts were found higher compared to DCM extracts at dose of 20 μl/ml of culture. Survival in polA, lexA and recA mutants were 39%, 47% and 55% while treated with hexane extract. Allium cepa test, mitotic index was decreased in dose-dependent way and various kinds of chromosomal aberrations were found. Vigna radiata seeds germination and other parameters were also affected when treated with contaminated soil. Oxidative stress in V. radiata roots were also showed under CLS microscope. Genotoxicity of contaminated soil extract was also confirmed by plasmid nicking test. Our study provides possible explanation for the assessment of potential health and environmental hazards of the industrial region.

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“…18−21 LNG or hormone activity has also been measured to reach hundreds of ng/kg in sediments and agricultural soils. 22,23 QUN is the prodrug of ethinylestradiol (EE2), and it is stored in body fat, and subsequently released slowly and likely converted into EE2. 24 QUN is about three times as potent as EE2 because of its much longer halflife.…”

Section: ■ Introductionmentioning

confidence: 99%

“…LNG has been found in sewage treatment plant effluents, surface waters, and groundwaters worldwide, including those in China . Its measured concentrations are approximately 100 ng/L. − LNG or hormone activity has also been measured to reach hundreds of ng/kg in sediments and agricultural soils. , QUN is the prodrug of ethinylestradiol (EE2), and it is stored in body fat, and subsequently released slowly and likely converted into EE2 . QUN is about three times as potent as EE2 because of its much longer half-life .…”

Section: Introductionmentioning

confidence: 99%

Degradation Kinetics and Transformation Products of Levonorgestrel and Quinestrol in Soils

Tang

et al. 2019

J. Agric. Food Chem.

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Levonorgestrel (LNG) and quinestrol (QUN) are typical endocrine disruptors that enter the soil via sewage irrigation and sludge return. However, the fates of both compounds in soil are not well-understood. Laboratory microcosm studies were conducted to fill the gap of understanding of LNG and QUN behavior in soils. High values of goodness-of-fit indices (GFIs) were obtained using the double-first-order in parallel (DFOP) model and the single-first-order (SFO) model to fit the degradation kinetics of LNG and QUN in soils, respectively. The end-points (DT 50 and DT 90 ) of LNG and QUN were positively correlated with soil total organic carbon (TOC). Soil water content and temperature were observed to be critical factors in degradation of LNG and QUN. The degradation rates of LNG and QUN were very slow under sterile and flooded conditions, indicating that the aerobic microbial degradation was dominant in the degradation of LNG and QUN. Moreover, major transformation products were identified, and biodegradation pathways of LNG and QUN were proposed. The present study is expected to provide basic information for ecological risk assessment of LNG and QUN in the soil compartment.

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Determination of endocrine-disrupting potencies of agricultural soils in China via a battery of steroid receptor bioassays

Cited by 25 publications

References 34 publications

Genotoxic hazard and oxidative stress induced by wastewater irrigated soil with special reference to pesticides and heavy metal pollution

Genotoxic hazard and oxidative stress induced by wastewater irrigated soil with special reference to pesticides and heavy metal pollution

Genotoxic Hazard and Oxidative Stress Induced by Wastewater Irrigated Soil With Special Reference to Pesticides and Heavy Metal Pollution

Degradation Kinetics and Transformation Products of Levonorgestrel and Quinestrol in Soils

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