Determination of enantiomeric impurity of linezolid by capillary electrophoresis using heptakis-(2,3-diacetyl-6-sulfato)-β-cyclodextrin

Chiral Separations by Capillary Electrophoresis

“…Recent applications using single-isomeric CD have been reported [53,54]. In [53], a method was developed for the enantiomeric impurity determination of linezolid.…”

“…In [53], a method was developed for the enantiomeric impurity determination of linezolid. The chiral selector used was heptakis(2,3-diacetyl-6-sulfato)-β-CD (HDAS-β-CD), and the authors employed the charged resolving agent migration model (CHARM), a set of guidelines proposed by Williams and Vigh [55] which helps with the selection of optimum separation conditions when charged CDs are used as chiral selectors.…”

6-O-(2-hydroxybutyl)-β-CD as a chiral selector for nonaqueous capillary electrophoretic separation of chiral drugs

“…The numerical values of chemical shifts obtained from the NMR spectra were as follows: 13 From the 13 C-NMR spectra of 6-O-(2-hydroxybutyl)-β-CD, the degree of substitution was 4.00.…”

“…Other separation methods used for enantiomer separation included thin-layer chromatography (TLC) and gas chromatography (GC) [2,3]. However, a rapidly growing number of studies have been reported on the use of capillary electrophoresis (CE) in the chiral separation [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19]. Common CE method was generally carried out in aqueous medium; as a result, hydrophilic analyte was often required during the analysis procedure.…”

Determination of linezolid and its achiral impurities using sweeping preconcentration by micellar capillary electrophoresis

“…Separation of linezolid and its chiral impurity-R-linezolid using heptakis-(2,3-diacetyl-6-sulfato)-beta-cyclodextrin as chiral selector have been already conducted in our laboratory and the results were presented [32].…”