Determination of EDTA and DTPA as their Fe(III) complexes in pulp and paper mill process and waste waters by liquid chromatography

Sillanpää, Mika; Kokkonen, R.; Sihvonen, Marja-Liisa

doi:10.1016/0003-2670(94)00535-t

Cited by 52 publications

(13 citation statements)

References 12 publications

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“…In waste waters and especially in pulp and paper wastes EDTA and DTPA can be determined by the liquid chromatography method in the form of Fe(III) complexes. The high performance liquid chromatography and electrophoresis methods can be used to determine Fe(III)-IDS complexes in cosmetic products (Sillanpää, et al 1995;Katata, et al 2006). The rapid UV-Vis method of determination of IDS was described in (Reinecke, et al 2000).…”

Section: Determination Of Aminopolycarboxylic Acidsmentioning

confidence: 99%

Chelating Agents of a New Generation as an Alternative to Conventional Chelators for Heavy Metal Ions Removal from Different Waste Waters

Kołodyńska¹

2011

Expanding Issues in Desalination

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Section: Determination Of Aminopolycarboxylic Acidsmentioning

confidence: 99%

Chelating Agents of a New Generation as an Alternative to Conventional Chelators for Heavy Metal Ions Removal from Different Waste Waters

Kołodyńska¹

2011

Expanding Issues in Desalination

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“…The waste water treatment plants are not able to degrade EDTA and DTPA and several environmental concerns arise due to the perturbation of the natural speciation of metals in the aquatic resources (Bucheli-Witschel and Egli 2001). Another consequence is the possible contribution for the eutrophization of the aquatic resources due to the nitrogen present in both EDTA (two atoms) and DTPA (three atoms) molecules (Sillanpaa et al 1995).…”

Section: Introductionmentioning

confidence: 99%

Pre-treatment of the paper pulp in the bleaching process using biodegradable chelating agents

Pinto¹,

Ascenso

Barros

et al. 2013

Int. J. Environ. Sci. Technol.

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The aim of this work was to study the application of two biodegradable chelating agents, pyridine-2,6-dicarboxylic acid (PDA) and methylglycinediacetic acid (MGDA), in the treatment of the pulp, prior to hydrogen peroxide bleaching. Such compounds must remove transition metals (Mn, Fe and Cu) from pulp, that catalyze the degradation of hydrogen peroxide, and Ca, which is also problematic due to the formation of precipitates that accumulate in the equipment. Computer simulations were first performed to study the best conditions for metal complexation, and optimum pH was defined as 5-5.5 for PDA and 6.5-7 for MGDA. Metals removal from the pulp, as well as the subsequent bleaching process (Q-P1-Paa-P2), were tested experimentally, and performances were compared to ethylenediaminetetracetic acid (EDTA). PDA removed both Mn and Ca efficiently, leaving most Mg in the pulp after first chelation stage, while MGDA had a lower Ca removal, even using a higher pH and concentration. Residual hydrogen peroxide and kappa number after peroxide stages showed a similar bleaching efficiency between the studied compounds and EDTA.

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“…Several reports showed that the analysis of ethylenediaminetetraacetic acid (EDTA) could be accomplished by converting EDTA to a single metal complex, typically with iron (III)[12] and copper (II)[13–15]. An analogous approach was taken in the current HOPO analysis.…”

Section: Resultsmentioning

confidence: 99%

Characterization, HPLC method development and impurity identification for 3,4,3-LI(1,2-HOPO), a potent actinide chelator for radionuclide decorporation

Liu

Wang

et al. 2015

Journal of Pharmaceutical and Biomedical Analysis

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3,4,3-LI(1,2-HOPO), 1,5,10,14-tetra(1-hydroxy-2-pyridon-6-oyl)-1,5,10,14-tetraazatetradecane), is a potent octadentate chelator of actinides. It is being developed as a decorporation treatment for internal contamination with radionuclides. Conventional HPLC methods exhibited speciation peaks and bridging, likely attributable to the agent’s complexation with residual metallic ions in the HPLC system. Derivatization of the target ligand in situ with Fe(III) chloride, however, provided a single homogeneous iron-complex that can readily be detected and analyzed by HPLC. The HPLC method used an Agilent Eclipse XDB-C18 column (150 mm × 4.6 mm, 5 μm) at 25 °C with UV detection at 280 nm. A gradient elution, with acetonitrile (11% to 100%)/buffer mobile phase, was developed for impurity profiling. The buffer consisted of 0.02% formic acid and 10 mM ammonium formate at pH 4.6. An Agilent 1200 LC-6530 Q-TOF/MS system was employed to characterize the [Fe(III)-3,4,3-LI(1,2-HOPO)] derivative and impurities. The proposed HPLC method was validated for specificity, linearity (concentration range 0.13–0.35 mg/mL, r = 0.9999), accuracy (recovery 98.3–103.3%), precision (RSD ≤ 1.6%) and sensitivity (LOD 0.08 μg/mL). The LC/HRMS revealed that the derivative was a complex consisting of one 3,4,3-LI(1,2-HOPO) molecule, one hydroxide ligand, and two iron atoms. Impurities were also identified with LC/HRMS. The validated HPLC method was used in shelf-life evaluation studies which showed that the API remained unchanged for one year at 25°C/60% RH.

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Determination of EDTA and DTPA as their Fe(III) complexes in pulp and paper mill process and waste waters by liquid chromatography

Cited by 52 publications

References 12 publications

Chelating Agents of a New Generation as an Alternative to Conventional Chelators for Heavy Metal Ions Removal from Different Waste Waters

Chelating Agents of a New Generation as an Alternative to Conventional Chelators for Heavy Metal Ions Removal from Different Waste Waters

Pre-treatment of the paper pulp in the bleaching process using biodegradable chelating agents

Characterization, HPLC method development and impurity identification for 3,4,3-LI(1,2-HOPO), a potent actinide chelator for radionuclide decorporation

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