Determination of early urinary renal injury markers in obese children

Göknar, Nilüfer; Öktem, Faruk; Özgen, İlker Tolga; Torun, Emel; Küçükkoç, Mehmet; Demir, Ayşegül; Cesur, Yaşar

doi:10.1007/s00467-014-2829-0

Cited by 53 publications

(65 citation statements)

References 35 publications

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“…In addition, these authors reported that a change in BMI over the 6 years of the study, but not the baseline BMI itself, was associated with microalbuminuria, indicating that the growth in body mass may occur faster than the kidneys can adapt [13]. Microalbuminuria was not found to be different between obese children and healthy controls in the study of Goknar et al [11].…”

Section: Microalbuminuriamentioning

confidence: 86%

“…Furthermore, urine NGAL can be used as an early biomarker of diabetic nephropathy [16]. However, urine NGAL was not found to be different between obese children and healthy controls in Goknar et al's study [11].…”

Section: Microalbuminuriamentioning

confidence: 90%

“…Their results indicate that urinary NAG was elevated at week 33 and 36 in SHROB rats only, but not in SHR-lean rats at any time point [18], indicating that NAG may be an early reliable marker for obesity-related renal injury. Goknar et al demonstrated that urinary NAG was significantly elevated in obese children compared with lean controls [11].…”

Section: N-acetyl-beta-d-glucosaminidasementioning

confidence: 98%

“…In a casecontrol study of 40 children undergoing cardiac surgery, including 20 children with AKI (defined as a 50 % increase in SCr) and 20 without AKI, urinary KIM-1 levels were significantly increased, with an area under the time-concentration curve of 0.83 at the 12-h time-point [20]. Goknar et al's study showed that obese children had a higher urinary KIM-1 level compared with healthy controls [11]. These results suggest that KIM-1 may be a potential screening biomarker for the detection of early renal injury in obese children.…”

Section: Kidney Injury Moleculementioning

confidence: 99%

“…Goknar et al recently evaluated early urine renal injury markers in obese children [11]. In this section we discuss their …”

Section: Biomarkers Of Early Renal Injury In Obese Childrenmentioning

confidence: 99%

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Early markers of obesity-related renal injury in childhood

Ding

Mak

2014

Pediatr Nephrol

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Childhood obesity has become a global epidemic. Recent epidemiological data suggest that obesity is associated with increased risk of renal injury in children. The onset of obesity-associated renal disease is insidious and asymptomatic, so early markers will be extremely useful in its prevention and treatment. Biomarker discovery can be focused on unbiased or biased (candidate) approaches. Unbiased approaches using innovative technologies, such as proteomics and metabolomics, have uncovered candidates that are emerging as plausible biomarkers for such renal disorders as obstructive uropathy and diabetic nephropathy. Biased approaches are based on hypotheses related to glomerular or tubular injury pathophysiology in obesity. Goknar et al. (Pediatric Nephrology 2014; doi: 10.1007/s00467-014-2829 recently evaluated early urine renal injury markers, namely, microalbuminuria, N-acetyl-beta-D-glucosaminidase (NAG), neutrophil gelatinase-associated lipocalin, and kidney injury molecule (KIM)-1, in obese children. They reported that obese children had higher urinary NAG and KIM-1 levels than healthy controls. Longitudinal observation studies are needed to evaluate whether these tubular damage markers are useful as early markers of renal injury in obese children.

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Section: Microalbuminuriamentioning

confidence: 86%

Section: Microalbuminuriamentioning

confidence: 90%

Section: N-acetyl-beta-d-glucosaminidasementioning

confidence: 98%

Section: Kidney Injury Moleculementioning

confidence: 99%

“…Goknar et al recently evaluated early urine renal injury markers in obese children [11]. In this section we discuss their …”

Section: Biomarkers Of Early Renal Injury In Obese Childrenmentioning

confidence: 99%

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Early markers of obesity-related renal injury in childhood

Ding

Mak

2014

Pediatr Nephrol

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Biomarkers Associated With Severe COVID-19 Among Populations With High Cardiometabolic Risk

et al. 2023

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ImportanceCardiometabolic parameters are established risk factors for COVID-19 severity. The identification of causal or protective biomarkers for COVID-19 severity may facilitate the development of novel therapies.ObjectiveTo identify protein biomarkers that promote or reduce COVID-19 severity and that mediate the association of cardiometabolic risk factors with COVID-19 severity.Design, Setting, and ParticipantsThis genetic association study using 2-sample mendelian randomization (MR) was conducted in 2022 to investigate associations among cardiometabolic risk factors, circulating biomarkers, and COVID-19 hospitalization. Inputs for MR included genetic and proteomic data from 4147 participants with dysglycemia and cardiovascular risk factors collected through the Outcome Reduction With Initial Glargine Intervention (ORIGIN) trial. Genome-wide association study summary statistics were obtained from (1) 3 additional independent plasma proteome studies, (2) genetic consortia for selected cardiometabolic risk factors (including body mass index [BMI], type 2 diabetes, type 1 diabetes, and systolic blood pressure; all n &gt;10 000), and (3) the COVID-19 Host Genetics Initiative (n = 5773 hospitalized and 15 497 nonhospitalized case participants with COVID-19). Data analysis was performed in July 2022.ExposuresGenetically determined concentrations of 235 circulating proteins assayed with a multiplex biomarker panel from the ORIGIN trial for the initial analysis.Main Outcomes and MeasuresHospitalization status of individuals from the COVID-19 Host Genetics Initiative with a positive COVID-19 test result.ResultsAmong 235 biomarkers tested in samples totaling 22 101 individuals, MR analysis showed that higher kidney injury molecule-1 (KIM-1) levels reduced the likelihood of COVID-19 hospitalization (odds ratio [OR] per SD increase in KIM-1 levels, 0.86 [95% CI, 0.79-0.93]). A meta-analysis validated the protective association with no observed directional pleiotropy (OR per SD increase in KIM-1 levels, 0.91 [95% CI, 0.88-0.95]). Of the cardiometabolic risk factors studied, only BMI was associated with KIM-1 levels (0.17 SD increase in biomarker level per 1 kg/m2 [95% CI, 0.08-0.26]) and COVID-19 hospitalization (OR per 1-SD biomarker level, 1.33 [95% CI, 1.18-1.50]). Multivariable MR analysis also revealed that KIM-1 partially mitigated the association of BMI with COVID-19 hospitalization, reducing it by 10 percentage points (OR adjusted for KIM-1 level per 1 kg/m2, 1.23 [95% CI, 1.06-1.43]).Conclusions and RelevanceIn this genetic association study, KIM-1 was identified as a potential mitigator of COVID-19 severity, possibly attenuating the increased risk of COVID-19 hospitalization among individuals with high BMI. Further studies are required to better understand the underlying biological mechanisms.

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Subclinical kidney injury before and 1 year after bariatric surgery among adolescents with severe obesity

Xiao

Devarajan

Inge

et al. 2015

Obesity

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ObjectiveTo assess subclinical kidney injury in severely obese adolescents by measuring biomarkers of early kidney disease and to assess changes in the levels of these biomarkers following bariatric procedure.Methods22 severely obese adolescents undergoing bariatric surgery with no microalbuminuria and normal kidney function were selected. Urinary NGAL, IL-18, and KIM-1 were measured at baseline, 6, and 12 months post-operatively. Biomarker levels were compared to 44 age-gender-matched lean controls.ResultsObese subjects had a mean baseline BMI of 48 kg/m2 that decreased by 34% at 1 year follow-up. Urine NGAL, IL-18 and KIM-1 were significantly elevated in obese compared to lean controls at baseline. The obese cohort had a further significant increase in NGAL and KIM-1 at 6 months, followed by decline at 1 year. The overall change in levels of all three biomarkers through 1 year after surgery, however, was not significant compared to baseline.ConclusionsAdolescent severe obesity is associated with increased urinary excretion of novel biomarkers of kidney injury, despite no microalbuminuria or decreased kidney function. This subclinical kidney injury persists 1 year after significant weight loss induced by bariatric surgery, suggesting that close long-term follow up of kidney status is warranted in these adolescents.

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Determination of early urinary renal injury markers in obese children

Abstract: This study shows that urinary NAG and KIM-1 could be used as a screening method for detection of early renal damage in obese children.

Cited by 53 publications

References 35 publications

Early markers of obesity-related renal injury in childhood

Early markers of obesity-related renal injury in childhood

Biomarkers Associated With Severe COVID-19 Among Populations With High Cardiometabolic Risk

Subclinical kidney injury before and 1 year after bariatric surgery among adolescents with severe obesity

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