Determination of dose and efficacy of atracurium for rapid sequence induction of anesthesia: A randomised prospective study

Chalermkitpanit, Pornpan; Rodanant, Oraluxna; Thaveepunsan, Winnie; Assavanop, Sireedhorn

doi:10.4103/joacp.joacp_36_19

Cited by 4 publications

(12 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…As per the results of our study, atracurium proved to be effective in achieving good intubating conditions within a minute, and the doses and grading were considered according to the study conducted by Chalermkitpanit P, et al . [ 6 ]. Also, we could achieve excellent intubating conditions with a success rate of 56.7% with a dose of 1 mg/kg.…”

Section: Discussionmentioning

confidence: 99%

“…In the study conducted by Chalermkitpanit P et al . [ 6 ] on elective surgical patients under general anaesthesia, the intubating conditions were graded as excellent in 51.4% of patients receiving 1 mg/kg of atracurium, in 43.6% of the patients with 0.75 mg/kg of atracurium and 26.3% patients with 0.6 mg/kg of atracurium ( P < 0.05). However, unlike their study, we conducted our study only on emergency laparotomies under general anaesthesia using modified RSI.…”

Section: Discussionmentioning

confidence: 99%

“…Sample size estimation was done using OpenEpi Software Version 2.3.1. At 95% confidence level, and 80% power of the study, based on the results of a previous study conducted by Chalermkitpanit P et al ,[ 6 ] the estimated sample size was 23, which was rounded off to 30 in each group. Study data were entered in Microsoft Excel and later analysed statistically using Statistical Package for Social Sciences for windows, version 19 (International Business Machines Corp, Armonk, N. Y, USA).…”

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

Comparison of different doses of atracurium for quality of muscle relaxation during modified rapid sequence induction in emergency laparotomy: A prospective randomised double blind study

Holkunde¹,

Masur²,

Patil³

et al. 2022

Indian J Anaesth

View full text Add to dashboard Cite

Background and Aims: In emergency and non-fasting patients posted for laparotomy under general anaesthesia, rapid sequence induction (RSI) is preferred, and it is routinely done by using succinylcholine or rocuronium. Using higher doses of atracurium [i.e. 3-4 times the 95% effective dose (ED95)] can provide acceptable intubating conditions in a short time. The primary objective of our study was to compare two different higher doses of atracurium to achieve good intubating conditions for RSI without using a priming dose. The secondary objective was to compare the duration of muscle relaxation using neuromuscular monitoring and haemodynamic responses during and after intubation. Methods: Sixty patients were enroled and randomly assigned into two groups:-, group A1 (atracurium: 0.75 mg/kg) and group A2 (atracurium: 1 mg/kg). After premedication, anaesthesia was induced with propofol 2-2.5 mg/kg and atracurium injections, followed by intubation within a minute by trained anaesthesiologists. Meanwhile, intubating conditions, neuromuscular monitoring using train-of-four (TOF) measurements and post-tetanic-count and haemodynamics were recorded. Data were analysed statistically by using the Chi-square test and Student’s t-test. Results: Excellent intubation conditions (without coughing or bucking) were attained in 56.7% of cases in group A2 and in 13.3% in group A1 ( P < 0.001). Duration of muscle relaxation, measured by time until TOF is two, was more prolonged in group A2 (79.2 ± 9.2 min) than in group A1 (60.13 ± 8.7 min, P < 0.001). Conclusion: Acceptable intubating conditions can be achieved in a minute with the use of a high dose of atracurium (1 mg/kg) during RSI. Hence, atracurium can be used as an alternative drug for RSI.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Comparison of different doses of atracurium for quality of muscle relaxation during modified rapid sequence induction in emergency laparotomy: A prospective randomised double blind study

Holkunde¹,

Masur²,

Patil³

et al. 2022

Indian J Anaesth

View full text Add to dashboard Cite

show abstract

“…One of the study conducted recently has shown that when Atracurium is given at a dose of 1 m/kg or 0.75 mg/kg it can be provide fast and satisfactory intubating conditions within 1 minute. 19 Therefore, it can be used as an alternative neuromuscular blocker for rapid sequence induction.…”

Section: Original Articlementioning

confidence: 99%

Atracurium for Rapid Sequence Induction; A dose determining Randomized Control Trial at a Tertiary Care Hospital.

Muhammad Haroon Anwar,

Rana Imran Sikander,

Naheed Fatima

et al. 2024

Ann Pak Inst Med Sci

View full text Add to dashboard Cite

Introduction: Expert airway management is one of the essential anesthetic skills. Rapid Sequence induction is a technique of providing rapid securement of airway with endotracheal tube in patients who are at risk of aspiration. Objective: To find out the efficacy of 3-4 ED95 dose of Atracurium in providing optimal intubating conditions for Rapid Sequence Induction. Methodology: Single-blind randomized control trial was carried out Department of Anesthesia and Critical Care Medicine, Pakistan Institute of Medical Sciences (PIMS), Islamabad. 118 patients were included and divided into two groups by help of computer-generated random numbers. All the patients were pre-medicated with 8 mg of IV Dexamethasone. Group A patients received 1 mg/kg while group B patients received 0.75 mg/kg of Atracurium. Intubating conditions were assessed on the basis of number of coughing episodes along with degree of vocal cord movement or paralysis. Results: Patients who received 0.75 mg/kg of Atracurium had statistically significant better intubating conditions as compared to those receiving 1 mg/kg of Atracurium (p value < 0.05). Coughing episodes were more common among patients receiving higher dose of Atracurium while degree of vocal cord paralysis was similar in both groups. Furthermore 75% of histamine related adverse effects such as erythema and bronchospasm were observed in higher dose group. The difference was statistically significant with a p value of <0.05. Conclusion: Atracurium at a dose of 0.75 mg/kg along with pre-medication with 8 mg of IV Dexamethasone provided better and safer intubating conditions for rapid sequence induction.

show abstract

“…Oleh karena itu, atracurium mencegak ikatan asetilkolin sehingga neuron motorik tidak dapat depolarisasi. Atracurium tidak memberikan efek pada tekanan intraocular (Butterworth, et al 2013;Chalermkitpanit, et al 2020).…”

Section: Jurnal Kesehatanunclassified

Manajemen anestesi pada ablasio retina: laporan kasus

Makrufa

2022

SEHATI

View full text Add to dashboard Cite

Retinal detachment is a separation between retinal photoreceptor layer and retinal epithelial layer below. Retinal detachment happens in 67% people with myopia. Retinal detachment also happens in people with cataract surgery history and blunt trauma in the eye. Patients with retinal detachment may present with a history of photopsia. The patient also presents with visual field loss, usually starts in the periphery, and then moving to the central. Physical examination can be done with fundoscopy examination that may present with a retinal detachment if the eye was moving. Radiological examination can be done to support the diagnosis. Management of retinal detachment is by vitrectomy to lift up the material that causing traction, subretinal internal liquid drainage, and injection of air or gasses to maintain retinal position. A man aged 53 years old come with visual loss in the right eye. Patient felt that there is a foreign object in his right eye, so the patient rub his right eye to release the foreign object. Patient’s right eye only can see blurred from the side, but in the central he can not see anything. The physical examination presents with a retinal detachment in the right eye. Patient has controlled hypertension. There is no previous allergic or operative history. The patient receives an operative vitrectomy with general anesthesia. The patient receives preoperative, intraoperative, and postoperative to support the surgery..

show abstract

Determination of dose and efficacy of atracurium for rapid sequence induction of anesthesia: A randomised prospective study

Cited by 4 publications

References 22 publications

Comparison of different doses of atracurium for quality of muscle relaxation during modified rapid sequence induction in emergency laparotomy: A prospective randomised double blind study

Comparison of different doses of atracurium for quality of muscle relaxation during modified rapid sequence induction in emergency laparotomy: A prospective randomised double blind study

Atracurium for Rapid Sequence Induction; A dose determining Randomized Control Trial at a Tertiary Care Hospital.

Manajemen anestesi pada ablasio retina: laporan kasus

Contact Info

Product

Resources

About