Determination of domperidone in human plasma using high performance liquid chromatography with fluorescence detection for clinical application

Yoshizato, Tsuneaki; Tsutsumi, Kimiko; Kotegawa, Tsutomu; Imai, Hiromitsu; Nakano, Shigeyuki

doi:10.1016/j.jchromb.2014.05.004

Cited by 12 publications

(11 citation statements)

References 17 publications

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“…A liquid-liquid extraction process and HPLC fluorometric detection method moderately optimized from literatures 30 , 31 were employed to analyze the plasma samples. 200 μL plasma was mixed with 20 μL IS solution (1.024 μg/mL propranolol hydrochloride methanol solution) and 100 μL 0.1 mol/L NaOH solution.…”

Section: Methodsmentioning

confidence: 99%

Fused Deposition Modeling (FDM) 3D Printed Tablets for Intragastric Floating Delivery of Domperidone

Chai

Wang

et al. 2017

Sci Rep

246

119

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The aim of this study was to explore the feasibility of fused deposition modeling (FDM) 3D printing to prepare intragastric floating sustained release (FSR) tablets. Domperidone (DOM), an insoluble weak base, was chosen as a model drug to investigate the potential of FSR in increasing its oral bioavailability and reducing its administration frequency. DOM was successfully loaded into hydroxypropyl cellulose (HPC) filaments using hot melt extrusion (HME). The filaments were then printed into hollow structured tablets through changing the shell numbers and the infill percentages. Physical characterization results indicated that the majority of DOM gradually turned into the amorphous form during the fabrication process. The optimized formulation (contain 10% DOM, with 2 shells and 0% infill) exhibited the sustained release characteristic and was able to float for about 10 h in vitro. Radiographic images showed that the BaSO4-labeled tablets were retained in the stomach of rabbits for more than 8 h. Furthermore, pharmacokinetic studies showed the relative bioavailability of the FSR tablets compared with reference commercial tablets was 222.49 ± 62.85%. All the results showed that FDM based 3D printing might be a promising way to fabricate hollow tablets for the purpose of intragastric floating drug delivery.

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Section: Methodsmentioning

confidence: 99%

Fused Deposition Modeling (FDM) 3D Printed Tablets for Intragastric Floating Delivery of Domperidone

Chai

Wang

et al. 2017

Sci Rep

246

119

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“…There are several reports exhibit various methods for quantifying domperidone in plasma matrices. The methods implement a high liquid chromatography approach coupled with UV (HPLC-UV), fluorescence, or tandem mass spectrometry (HPLC-MS/MS) detection [2][3][4][5][6][7][8][9][10][11][12]. Other reports applied the ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) [13][14] and the ultra-fast liquid chromatography (UFLC) method with fluorescence detection [15].…”

Section: ■ Introductionmentioning

confidence: 99%

Validation and Quantification of Domperidone in Spiked Plasma Matrix Using Reversed Phase HPLC-UV Method

et al. 2021

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Pharmacokinetics studies of domperidone generally analyze plasma matrix samples. The present work aimed to develop and validate a rapid and simple reversed phase-HPLC method for quantifying domperidone in plasma matrices. The chromatographic method implemented: 1. Luna Phenomenex® C18 (250 mm × 4.6 mm i.d; 5 µm) column, 2. isocratic mobile phase mixture of phosphate buffer 0.02 M:acetonitrile (70:30, v/v) with a flow rate of 1 mL/min, 3. UV detection at 285 nm. Domperidone and propranolol hydrochloride (as internal standard) were extracted from the deproteinated plasma sample. The method linearity was 0.998 in the range concentration of 15–200 ng/mL. The percentage of accuracy error was between -8.49–4.31%, while the percentage coefficient variation of precision ranged between 5.11–14.24%. This proposed method was simple, rapid (separation time less than 10 min), and selective. The validation parameters responses satisfied the method's requirements to determine domperidone in a plasma sample.

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“…Domperidone maleate (DM) (6-chloro-3-[1- [3-(2-oxo-3H-benzimidazol-1-yl)propyl] piperidin]-1H-benzimidazol-2-one), shown in Figure 1, is a powerful prokinetic drug that regulate the peristaltic movement of the gastrointestinal tract by acting on dopamine receptors as an antagonist. DM is used in the treatment of motility disorders, nausea associated with chemotherapeutic agents, gastroesophageal reflux disorders, and Parkinson's disease [3,4]. PSS and DM are used in combination form for the management of GERD and peptic ulcer.…”

Section: Introductionmentioning

confidence: 99%

Development and validation of high-performance liquid chromatography method for the simultaneous monitoring of pantoprazole sodium sesquihydrate and domperidone maleate in plasma and its application to pharmacokinetic study

Abbas

Saadullah

Rasul

et al. 2020

Acta Chromatographica

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A sensitive, inexpensive high-performance liquid chromatography–ultraviolet detection (HPLC–UV) method has been developed and validated for the simultaneous monitoring of pantoprazole sodium sesquihydrate (PSS) and domperidone maleate (DM) in rabbit plasma on a C18 column with UV detection at 285 nm. Box–Behnken design was used with 3 independent variables, namely, flow rate (X1), mobile phase composition (X2), and phosphate buffer pH (X3), which were used to design mathematical models. Response surface design was applied to optimize the dependent variables, i.e., retention time (Y1 and Y2) and percentage recoveries (Y3 and Y4) of PSS and DM. The method was sensitive and reproducible over 1.562 to 25 μg/mL. The effect of the quadratic outcome of flow rate, mobile phase composition, and buffer pH on retention time (p ˂ 0.001) and percentage recoveries of PSS and DM (p = 0.0016) were significant. The regression values obtained from analytical curve of PSS and DM were 0.999 and 0.9994, respectively. The percentage recoveries of PSS and DM were ranged from 94.5 to 100.41% and 94.77 to 100.31%, respectively. The developed method was applied for studying the pharmacokinetics of PSS and DM. The Cmax of test and reference formulations were 48.06 ± 0.347 μg/mL and 46.31 ± 0.398 μg/mL for PSS, and 15.11 ± 1.608 μg/mL and 12.06 ± 1.234 μg/mL for DM, respectively.

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Determination of domperidone in human plasma using high performance liquid chromatography with fluorescence detection for clinical application

Cited by 12 publications

References 17 publications

Fused Deposition Modeling (FDM) 3D Printed Tablets for Intragastric Floating Delivery of Domperidone

Fused Deposition Modeling (FDM) 3D Printed Tablets for Intragastric Floating Delivery of Domperidone

Validation and Quantification of Domperidone in Spiked Plasma Matrix Using Reversed Phase HPLC-UV Method

Development and validation of high-performance liquid chromatography method for the simultaneous monitoring of pantoprazole sodium sesquihydrate and domperidone maleate in plasma and its application to pharmacokinetic study

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