Determination of Dithiocarbamates and Milneb Residues in Foods by Gas Chromatography-Mass Spectrometry

Abstract

A highly sensitive gas chromatographic-mass spectrometric (GC-MS) method was developed for dithiocarbamates (DTCs) and milneb in foods. DTCs and milneb were extracted from foods with cysteineῌEDTA solution as sodium salts, and methylated with methyl iodide. Methyl derivatives of DTCs and milneb were cleaned up on a neutral alumina mini column and determined by GC-MS. The mean recoveries of DTCs and milneb were in the range of 72ῌ120ῌ, except for methiram. The quantification limits were 0.01 mg/kg (as CS 2 ) in foods except tea (0.1 mg/kg as CS 2 ). The developed method was applied to 10 compounds (4 dimethyldithiocarbamates, 3 ethylenebisdithiocarbamates, polycarbamates, propineb and milneb).

Advances in the Detection of Dithiocarbamate Fungicides: Opportunities for Biosensors

“…As with many other pesticide classes, the most selective methods for the determination of DTFs are based on gas chromatography coupled with-mass spectrometry (GC-MS) [ 6 ] and on reverse phase liquid chromatography coupled with optical, electrochemical, or mass-spectrometry detectors [ 7 , 8 , 9 , 10 ].…”

“…Nakamura et al described a GC-MS method for the detection of 10 dithiocarbamates in foods [ 6 ]. The compounds were extracted as water-soluble sodium salts with cysteine and ethylenediaminetetraacetic acid (EDTA) and then were derivatized by methylation.…”

Chromatographic determination of fungicides in biological and environmental matrices. New achievements

“…Recoveries were 72–120%, except for methiram. The LOQ was 0.01 mg/kg (Nakamura et al , ). A GC‐ECD method was applied for the investigation of the matrix effect in apple, mango, papaya, banana, pineapple and melon extracts.…”

Design, synthesis and antimicrobial activities of novel 1,3,5-thiadiazine-2-thione derivatives containing a 1,3,4-thiadiazole group

“…1A) and milneb (Fig. 1B), containing the 1,3,5-thiadiazine-2-thione moiety, were developed as the important agricultural nematicide and fungicide, respectively (Lam et al, 1993; Nakamura et al, 2010). Recently, Mao et al (2017) found that dazomet could be applied as a promising agricultural bactericide to effectively control ginger blast in field trials (Mao et al, 2017).…”