Determination of Dimenhydrinate Nasal Delivery System in the Blood by RP-LC

Özkan, Cansel Köse; Taşdemir, Umut; Taş, Çetin; Savaşer, Ayhan; Erol, Halil; Özkan, Yalçın

doi:10.1007/s10337-013-2531-6

Cited by 13 publications

(8 citation statements)

References 11 publications

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“…2 ), however, the peak corresponding to diphenhydramine is much better in shape and provides higher area values and more reliable measurement than that of 8-chlorotheophylline; therefore quantification of DMH was based on measurement of diphenhydramine peak areas. The same principle was applied in previous publications dealing with the HPLC analysis of DMH based on the diphenhydramine component only [7] , [8] . The linearity of the proposed GC procedure was evaluated by analyzing a series of different concentrations of DMH ( n = 8) over the concentration range 50–500 μg/mL.…”

Section: Resultsmentioning

confidence: 99%

“…The quantification of DMH in various drug formulations and/or biological samples was addressed in several reports. Analytical methodology in these reports involved the use of spectrophotometry [3] , [4] , adsorptive stripping voltammetry [5] , capillary electrophoresis [6] , liquid chromatography–tandem mass spectrometry (LC/MS/MS) [7] , high performance liquid chromatography (HPLC) with fluorescence detection [8] , HPLC with UV detection [9] and high performance thin layer chromatography (HPTLC) [10] , [11] . Recently, an electrochemical method based on batch injection analysis with multiple pulsed amperometric detection was reported for stoichiometric determination of DMH [12] .…”

Section: Introductionmentioning

confidence: 99%

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Selective determination of dimenhydrinate in presence of six of its related substances and potential impurities using a direct GC/MS method

Belal

Abdel‐Hay

Clark

2016

Journal of Advanced Research

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A novel simple, direct and selective gas chromatography–mass spectrometry (GC/MS) procedure was developed for the determination of the antihistamine drug dimenhydrinate (DMH) in presence of six of its related substances and potential impurities, namely, diphenylmethane, diphenylmethanol, benzophenone, orphenadrine, caffeine and 8-chlorocaffeine. The method involved resolution of the underivatized compounds using a trifluoropropylmethyl polysiloxane (Rtx-200) capillary column and the mass spectrometric detection was carried out in the electron-impact (EI) mode. Excellent baseline separation of DMH and the cited related substances was achieved in less than 15 min. Quantification of the parent drug DMH was based on measuring its peak area. The reliability and analytical performance of the proposed method were validated with respect to linearity, range, precision, accuracy, specificity, robustness, detection and quantification limits. Calibration curve of DMH was linear over the range 50–500 μg/mL with determination coefficient (R2) = 0.9982. The proposed method was successfully applied for the assay of DMH in tablets dosage form with recoveries >96.80%.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Selective determination of dimenhydrinate in presence of six of its related substances and potential impurities using a direct GC/MS method

Belal

Abdel‐Hay

Clark

2016

Journal of Advanced Research

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“…The functionalization of xanthine derivatives like caffeine or theophylline is of great interest for the development of pharmaceuticals . The examples shown in Scheme are approved drugs used for the treatment of type II diabetes (Linagliptin) and Parkinson's disease (Istradefylline) or to prevent postoperative vomiting and symptoms of motion sickness (Dimenhydrinate) . Lei et al.…”

Section: Methodsmentioning

confidence: 99%

Electrochemical C−H Functionalization of (Hetero)Arenes—Optimized by DoE

Dörr

Röckl

Rein

et al. 2020

Chemistry A European J

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A novel approach towards the activation of different arenes and purines including caffeine and theophylline is presented. The simple, safe and scalable electrochemical synthesis of 1,1,1,3,3,3‐hexafluoroisopropanol (HFIP) aryl ethers was conducted using an easy electrolysis setup with boron‐doped diamond (BDD) electrodes. Good yields up to 59 % were achieved. Triethylamine was used as a base as it forms a highly conductive media with HFIP, making additional supporting electrolytes superfluous. The synthesis was optimized using Design of Experiment (DoE) techniques giving a detailed insight to the significance of the reaction parameters. The mechanism was investigated by cyclic voltammetry (CV). Subsequent transition metal‐catalyzed as well as metal‐free functionalization led to interesting motifs in excellent yields up to 94 %.

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“…1 DIM is a salt composed by the combination of two active pharmaceutical ingredients in equimolar ratio (1:1): 8-chlorotheophylline (CTP) and diphenhydramine (DIP). 2 The ability to reduce nausea mainly occurs due to the presence of DIP, however, the concomitant presence of CTP (stimulant of the central nervous system) diminishes somewhat drowsiness induced by DIP.…”

Section: Introductionmentioning

confidence: 99%

Amperometric determination of 8-chlorotheophylline, caffeine, and diphenhydramine in a single run

Freitas¹,

Oliveira²,

Muñoz³

et al. 2017

Quim. Nova

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publicado na web em 15/05/2017 A simple method for simultaneous determination of 8-chlorotheophylline (CTP), caffeine (CAF), and diphenhydramine (DIP) using batch-injection analysis with multiple pulse amperometric detection (BIA-MPA) is reported. A sequence of three potential pulses (+1.10 V, +1.40 V, and +1.70 V) was applied to the boron-doped diamond working electrode with the acquisition of three distinct amperograms. CTP was detected selectively at +1.10 V, both CTP + CAF at +1.40 V and CTP + CAF + DIP at +1.70 V. The subtraction between the currents detected at the three potential pulses (with the use of correction factors) was the strategy used to achieve selectivity for the determination of CAF and DIP. The proposed method is simple, inexpensive, fast (120 injections h -1 ), presents good precision (RSD < 0.9%; n = 20), and adequate limits of detection (0.31, 0.49, and 0.76 µmol L -1 for CTP, CAF and DIP, respectively). The results obtained by BIA-MPA were similar to those found by high-performance liquid chromatography (95% confidence level).

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Determination of Dimenhydrinate Nasal Delivery System in the Blood by RP-LC

Cited by 13 publications

References 11 publications

Selective determination of dimenhydrinate in presence of six of its related substances and potential impurities using a direct GC/MS method

Selective determination of dimenhydrinate in presence of six of its related substances and potential impurities using a direct GC/MS method

Electrochemical C−H Functionalization of (Hetero)Arenes—Optimized by DoE

Amperometric determination of 8-chlorotheophylline, caffeine, and diphenhydramine in a single run

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