Determination of diffusion coefficient and partition coefficient of photoinitiator 2-hydroxy-2-methylpropiophenone in nanoporous polydimethylsiloxane network and aqueous poly(ethylene glycol) diacrylate solution

Shin, Kwangin.; Yu, Hyeonji; Kim, Jung-Wook

doi:10.1016/j.jiec.2017.08.002

Cited by 6 publications

(1 citation statement)

References 43 publications

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“…Henry’s adsorption constant is required to solve eq . However, since the adsorption proceeds with diffusion simultaneously, the direct measurement of the kinetic adsorption constant is complicated. − Here, we employed D.E. Liu’s method: calculating adsorption constant by using the partition coefficient following eq . , Where E ex indicates a size-exclusion factor, or the volume of liquid available to the protein in the membrane divided by the total pore volume of membrane, and E ad designates protein adsorption factors.…”

Section: Resultsmentioning

confidence: 99%

Diffusion of Protein Molecules through Microporous Nanofibrous Polyacrylonitrile Membranes

Zhao

Zhu

et al. 2021

ACS Appl. Polym. Mater.

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Porous nanofibrous membranes have ultrahigh specific surface areas and could be broadly employed in protein purification, enzyme immobilization, and biosensors with enhanced selectivity, sensitivity, and efficiency. However, large biomolecules, such as proteins, have hindered diffusion behavior in microporous media, significantly reducing the benefits provided by the nanofibrous membranes. The study of protein diffusion in polyacrylonitrile nanofibrous membranes produced under varied humidity and polymer concentration of electrospinning revealed that heterogeneous structures of the nanofibrous membranes possess much smaller effective pore sizes than the measured pore sizes, which significantly affects the diffusion of large molecules through the system though sizes of proteins and pH conditions also have great impacts. Only when the measured membrane pore size is at least 1000 times higher than the protein size, the diffusion behavior of the protein is predictable in the system. The results provide insights into the design and applications of proper nanofibrous materials for improved applications in protein purification and immobilizations.

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Section: Resultsmentioning

confidence: 99%

Diffusion of Protein Molecules through Microporous Nanofibrous Polyacrylonitrile Membranes

Zhao

Zhu

et al. 2021

ACS Appl. Polym. Mater.

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Role of Experimental Conditions on the Performance of a Radical Photoinitiator

2021

Photoinitiators

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A Microfluidic Model Artery for Studying the Mechanobiology of Endothelial Cells

Kang

Whang

et al. 2021

Adv Healthcare Materials

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Recent vascular mechanobiology studies find that endothelial cells (ECs) convert multiple mechanical forces into functional responses in a nonadditive way, suggesting that signaling pathways such as those regulating cytoskeleton may be shared among the processes of converting individual forces. However, previous in vitro EC-culture platforms are inherent with extraneous mechanical components, which may saturate or insufficiently activate the shared signaling pathways and accordingly, may misguide EC mechanobiological responses being investigated. Here, a more physiologically relevant model artery is reported that accurately reproduces most of the mechanical forces found in vivo, which can be individually varied in any combination to pathological levels to achieve diseased states. Arterial geometries of normal and diseased states are also realized. By mimicking mechanical microenvironments of early-stage atherosclerosis, it is demonstrated that the elevated levels of the different types of stress experienced by ECs strongly correlate with the disruption of barrier integrity, suggesting that boundaries of an initial lesion could be sites for efficient disease progression.

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Determination of diffusion coefficient and partition coefficient of photoinitiator 2-hydroxy-2-methylpropiophenone in nanoporous polydimethylsiloxane network and aqueous poly(ethylene glycol) diacrylate solution

Cited by 6 publications

References 43 publications

Diffusion of Protein Molecules through Microporous Nanofibrous Polyacrylonitrile Membranes

Diffusion of Protein Molecules through Microporous Nanofibrous Polyacrylonitrile Membranes

Role of Experimental Conditions on the Performance of a Radical Photoinitiator

A Microfluidic Model Artery for Studying the Mechanobiology of Endothelial Cells

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