Determination of different recreational drugs in sweat by headspace solid-phase microextraction gas chromatography mass spectrometry (HS-SPME GC/MS): Application to drugged drivers

Gentili, Stefano; Mortali, Claudia; Mastrobattista, Luisa; Berretta, Paolo; Zaami, Simona

doi:10.1016/j.jpba.2016.07.018

Cited by 40 publications

(17 citation statements)

References 18 publications

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“…S5B). Consistent with previous findings, consumed drugs that are detected on hands might originate from sweat secreted on the skin (47,48) or can be transferred upon contact (25,49).…”

Section: Molecular Networking To Characterize Matched Chemicals Betwesupporting

confidence: 91%

“…S8C and Dataset S1), used occasionally by volunteers, were found on hands of individuals but not on their phones. As highlighted above, the detection of molecules on the hands can result from sweat secreted by the skin (47,48) or can be transferred upon contact (25,49). The detection of chemicals on hands but not on phones indicates that not all lifestyle signatures from the hands are recovered on the phones, reinforcing that the overall profile is important to an investigator rather than the detection of individual molecules.…”

Section: Molecular Networking To Characterize Matched Chemicals Betwementioning

confidence: 99%

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Lifestyle chemistries from phones for individual profiling

Bouslimani

Melnik

et al. 2016

Proc. Natl. Acad. Sci. U.S.A.

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Imagine a scenario where personal belongings such as pens, keys, phones, or handbags are found at an investigative site. It is often valuable to the investigative team that is trying to trace back the belongings to an individual to understand their personal habits, even when DNA evidence is also available. Here, we develop an approach to translate chemistries recovered from personal objects such as phones into a lifestyle sketch of the owner, using mass spectrometry and informatics approaches. Our results show that phones' chemistries reflect a personalized lifestyle profile. The collective repertoire of molecules found on these objects provides a sketch of the lifestyle of an individual by highlighting the type of hygiene/beauty products the person uses, diet, medical status, and even the location where this person may have been. These findings introduce an additional form of trace evidence from skin-associated lifestyle chemicals found on personal belongings. Such information could help a criminal investigator narrowing down the owner of an object found at a crime scene, such as a suspect or missing person.skin | phones | lifestyle chemistries | trace evidence

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“…S5B). Consistent with previous findings, consumed drugs that are detected on hands might originate from sweat secreted on the skin (47,48) or can be transferred upon contact (25,49).…”

Section: Molecular Networking To Characterize Matched Chemicals Betwesupporting

confidence: 91%

Section: Molecular Networking To Characterize Matched Chemicals Betwementioning

confidence: 99%

Lifestyle chemistries from phones for individual profiling

Bouslimani

Melnik

et al. 2016

Proc. Natl. Acad. Sci. U.S.A.

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“…Tak opracowana metoda, po odpowiedniej walidacji, mogłaby być stosowana jako alternatywny materiał biologiczny, pobrany w sposób nieinwazyjny, np. podczas rutynowej kontroli kierowców na obecność substancji uzależniających [28].…”

Section: Zastosowanie Spme W Analizie Lekówunclassified

Solid phase microextraction (SPME) as a modern technique for the isolation of medications from biological samples

Roszkowska¹

2018

Farm Pol.

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“…Alternatively, blood samples can provide a possible correlation between compound concentration and toxic effects (Li, Shen, Jiang, Huang, & Zhuo, ; Maurer, , , ; Montenarh et al, ; Montenarh, Hopf, Maurer, Schmidt, & Ewald, ; Pizzolato, Alda, & Barceló, ; Pragst, ; Verstraet & Peat, ; Vincenti et al, ). The most commonly used techniques for extraction or pre‐treatment of samples for chromatographic analysis are liquid–liquid extraction (LLE) (Meyer et al, ; Montenarh et al, ; Staeheli, Poetzsch, Kraemer, & Steuer, ), solid phase extraction (SPE) (Dalsgaard et al, ; Mut, Grobosch, Binscheck‐Domaß, & Frenzel, ; Mut, Grobosch, Binscheck‐Domaß, & Frenzel, ; Steuer, Forss, Dally, & Kraemer, ; Tang, Ching, Lee, Lam, & Mak, ), liquid‐phase microextraction (LPME) (Meng, Zhang, Meng, Zhu, & Zheng, ; Nuhu, Basheer, & Saad, ) and solid‐phase microextraction (SPME) (Aleksa et al, ; Gentili, Mortali, Mastrobattista, Berretta, & Zaami, ; Olszowy et al, ). However, considering that nowadays simpler and cost‐effective sample preparation techniques are preferred in bio‐analytical methods, the LLE has attracted attention for toxicological analysis (Meyer, Weber, & Maurer, ; Vosough, Ghafghazi, & Sabetkasaei, ).…”

Section: Introductionmentioning

confidence: 99%

Development of a simple HPLC‐DAD multi‐analyte procedure and its application in cases evaluated by the Poison Control Center of São Paulo, Brazil

Oliveira

Zucoloto

Oliveira³

et al. 2018

Biomedical Chromatography

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This work describes a simple approach to overcome challenges in emergency toxicological analysis, using liquid-liquid extraction and high-performance liquid chromatography coupled with a diode-array detector (HPLC-DAD). A rapid procedure has been developed, for the extraction and detection of 19 analytes from the following drug classes: analgesics, benzodiazepines, antidepressants, anticonvulsants and drugs of abuse. These substances are relevant in the context of emergency toxicology in Brazil. The method has been validated according to international guidelines by establishing parameters such as lower limit of quantification, sensitivity, linearity, accuracy and precision. The intra and inter-day precision values, at the lowest concentration levels, have always been less than 20% considering its relative standard deviation. As for accuracy values, these have also been satisfactory (above 81.3%). This method was successfully applied in 201 blood samples from patients with suspected poisoning of the Poison Control Center of São Paulo (PCC-SP), Brazil. Finally, the developed method has shown to be relevant for emergency toxicology due to its high sensitivity and it could be also very useful in both fields of clinical and forensic toxicology.

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Determination of different recreational drugs in sweat by headspace solid-phase microextraction gas chromatography mass spectrometry (HS-SPME GC/MS): Application to drugged drivers

Cited by 40 publications

References 18 publications

Lifestyle chemistries from phones for individual profiling

Lifestyle chemistries from phones for individual profiling

Solid phase microextraction (SPME) as a modern technique for the isolation of medications from biological samples

Development of a simple HPLC‐DAD multi‐analyte procedure and its application in cases evaluated by the Poison Control Center of São Paulo, Brazil

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