Journal of Pharmaceutical and Biomedical Analysis

2006

DOI: 10.1016/j.jpba.2006.02.047

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Determination of desoxyepothilone B in nude mice plasma by liquid–liquid extraction and reversed-phase high-performance liquid chromatography

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Cited by 6 publications

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“…17 Traditional methods involve liquid-liquid extraction 18,19 or solid phase extraction. 20,21 Recently, several different types of solid phase microextraction 22 and liquid phase microextraction 23 methods have been developed, including dispersive liquid-liquid microextraction. 24 These methods are faster and more environmentally friendly than traditional extraction methods.…”

Section: Introductionmentioning

confidence: 99%

Supramolecular solvent‐based vortex‐mixed microextraction: Determination of chiral triazole fungicide in beer samples

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et al. 2018

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A supramolecular solvent composed of decanol in tetrahydrofuran/water was utilized for the simultaneous microextraction of chiral triadimefon and triadimenol in beer samples. Supramolecular solvents are nanostructured amphiphilic liquids that contain aqueous cavities, and the size of those cavities can be adjusted by the ratio of decanol, tetrahydrofuran, and water. The target analytes were mixed into the matrix sample and extracted in the supramolecular solvent phase, which was followed by separation and quantification by chiral liquid chromatography-mass spectrometry. The influences of some analytical parameters and matrix components were all examined. Under the optimized conditions, the method detection limits were in the range of 0.24 to 0.98 μg L (at a signal/noise of 3), with relative standard deviations between 1.6 and 5.7%. The linearities of the calibration plots were between 0.5 to 50 (triadimenol) and 1.0 to 100 μg L (triadimefon). When this method was applied to a spiked beer sample, the recoveries ranged from 84 to 100%.

“…17 Traditional methods involve liquid-liquid extraction 18,19 or solid phase extraction. 20,21 Recently, several different types of solid phase microextraction 22 and liquid phase microextraction 23 methods have been developed, including dispersive liquid-liquid microextraction. 24 These methods are faster and more environmentally friendly than traditional extraction methods.…”

Section: Introductionmentioning

confidence: 99%

Supramolecular solvent‐based vortex‐mixed microextraction: Determination of chiral triazole fungicide in beer samples

¹

,

²

,

³

et al. 2018

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A supramolecular solvent composed of decanol in tetrahydrofuran/water was utilized for the simultaneous microextraction of chiral triadimefon and triadimenol in beer samples. Supramolecular solvents are nanostructured amphiphilic liquids that contain aqueous cavities, and the size of those cavities can be adjusted by the ratio of decanol, tetrahydrofuran, and water. The target analytes were mixed into the matrix sample and extracted in the supramolecular solvent phase, which was followed by separation and quantification by chiral liquid chromatography-mass spectrometry. The influences of some analytical parameters and matrix components were all examined. Under the optimized conditions, the method detection limits were in the range of 0.24 to 0.98 μg L (at a signal/noise of 3), with relative standard deviations between 1.6 and 5.7%. The linearities of the calibration plots were between 0.5 to 50 (triadimenol) and 1.0 to 100 μg L (triadimefon). When this method was applied to a spiked beer sample, the recoveries ranged from 84 to 100%.

“…The currently used analytical methods for pollutants in water samples involves LLE , SPE , and so on. These traditional methods are time consuming, labor intensive, and environmentally unfriendly.…”

Section: Introductionmentioning

confidence: 99%

Determination of organochlorine pesticides in snow water samples by low density solvent based dispersive liquid–liquid microextraction

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et al. 2014

J of Separation Science

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A simple, rapid, efficient, and environmentally friendly pretreatment based on a low-density solvent based dispersive liquid-liquid microextraction was developed for determining trace levels of 17 organochlorine pesticides in snow. The parameters affecting the extraction efficiency, such as the type and volume of the extraction and dispersive solvents, extraction time, and salt content, were optimized. The optimized conditions yielded a good performance, with enrichment factors ranging from 271 to 474 and recoveries ranging from 71.4 to 114.5% and relative standard deviations between 1.6 and 14.8%. The detection limits, calculated as three times the signal-to-noise ratio, ranged from 0.02 to 0.11 μg/L. The validated method was used to successfully analyze 17 analytes in snow water samples, overcoming the drawbacks of some existing low-density solvent liquid microextraction methods, which require special devices, large volumes of organic solvents, or complicated operation procedures.

“…Most of them have used high-performance liquid chromatography (HPLC) with a UV detector, which suffers from a low sensitivity because of the weak UV absorbance of Epothilone D (250 nm) (Wang et al, 2005(Wang et al, , 2006. Recently, ultra-performance liquid chromatography (UPLC) has been developed to improve the chromatographic performance.…”

Section: Introductionmentioning

confidence: 99%

Determination of a novel epothilone D analog (AV‐EPO‐106) in human plasma using ultra‐performance liquid chromatography–tandem mass spectrometry

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et al. 2008

Biomedical Chromatography

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A novel ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS-MS) method has been established for the determination of a newly synthesized epothilone D analog (AV-EPO-106) in human plasma. The plasma samples were prepared by liquid-liquid extraction with cold tert-butyl methyl ether. The chromatographic separation was achieved within 5 min on a C(18) column with water-methanol (10:90, v/v) as mobile phase at a flow-rate of 0.8 mL/min. Mass transition of m/z 568.2 to 386.1 was measured for AV-EPO-106 in positive atmospheric pressure chemical ionization mode. A detailed validation of the method was performed as per the USFDA guidelines. For AV-EPO-106 at the concentrations of 1.0, 5.0 and 10.0 microg/mL in human plasma, the absolute extraction recoveries were 86.17, 85.24 and 85.69%, respectively. The linear quantification range of the method was 0.10-20.0 microg/mL in human plasma with linear correlation coefficients greater than 0.999. The intra-day and inter-day accuracy for AV-EPO-106 at the levels of 1.0, 5.0 and 10.0 microg/mL in human plasma fell in the ranges of 98.25-100.47 and 94.19-97.25%, and the intra- and inter-day precision were in the ranges of 4.75-6.30% and 8.89-10.45%, respectively. The method was successfully applied to quantify AV-EPO-106 in human plasma to determine the half-life of this compound in human plasma.

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