Determination of dermatology life quality index, and serum C-reactive protein and plasma interleukin-6 levels in patients with chronic urticaria

Abstract

IntroductionC-reactive protein (CRP) and interleukin-6 (IL-6), which is one of its most important simulators, were determined in great amounts in the sera of patients with chronic urticaria (CU).AimTo determine the levels of IL-6 in patients with urticaria, and evaluate its relationship with urticaria activity scores and Dermatology Life Quality Index (DLQI).Material and methodsFifty-three patients with CU were included in the study successively by determining their urticaria activity scores (0-3) and DLQI (0-5). The CRP and IL-6 were measured by immune assay methods. Thirty-two healthy subjects were included as a control group.ResultsSerum levels of IL-6 and CRP were significantly higher in patients with CU compared to healthy controls (p < 0.001, p = 0.026 respectively). There was a statistically significant correlation among urticaria activity scores and IL-6 and CRP concentration (p = 0.004, p = 0.042). This correlation was more significant in patients who had moderate and severe disease activity scores than in those who had mild disease activity score (p < 0.001, p < 0.001, respectively). There was a statistically significant association between DLQI and IL-6 (p = 0.025). This correlation was very significant in patients who had severe and very severe disease activity scores (p < 0.001, p < 0.001, respectively). DLQI scores and serum levels of IL-6 were significantly different in the very severe group compared to healthy controls (p = 0.024).ConclusionsThe levels of CRP and IL-6 are increased in patients with CU. A relationship of DLQI and urticaria activity scores with CRP and IL-6 was found. These findings support the relationship between the inflammatory process in CU and the clinical findings.

CRP, D-dimer, fibrinogen and ESR as predictive markers of response to standard doses of levocetirizine in patients with chronic spontaneous urticaria

“…The role of D-dimer and activation of coagulation in CSU pathogenesis is widely discussed (3)(4)(5). Patients with high levels of D-dimer, fibrinogen and/or CRP are shown to have severe CSU (3,5,6) that is in the line with the results of our study. We reported elevation of total IgE serum levels in responders with mild CSU that is contradictory to the findings by Kessel …”

Investigation of dermatology life quality index and serum prolactin and serum dehydroepiandrosterone sulphate levels in patients with chronic urticaria

“…1 Dysfunction of the neuroendocrine-immune system due to stress may play a role in the pathogenesis of urticaria. 2 It has been demonstrated that relative deficiency of dehydroepiandrosterone sulphate (DHEA-S) is associated with various inflammatory and immunemediated diseases, as well as stressful disorders, [3][4][5] including chronic urticaria. 6,7 It has been shown that both prolactin (PRL) and DHEA-S hormones have multiple immunomodulatory effects.…”

Occurrence of sleep-related breathing disorders in patients with chronic urticaria at its asymptomatic or oligosymptomatic stages

“…Many papers reported a reduction in the quality of life (QoL) in patients with chronic urticaria (CU) [1][2][3][4]. The degree of reduction was comparable to that in coronary artery disease and significantly higher than in other dermatological diseases, such as psoriasis or acne [5].…”