Determination of daminozide in apples and apple leaves by liquid chromatography–mass spectrometry

Mol, Hans; Dam, R.C.J. van; Vreeken, Rob J.; Steijger, O.M.

doi:10.1016/s0021-9673(98)00915-7

Cited by 30 publications

(14 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Other actions can be taken, such as the dilution of the sample (or extract), the main drawback being to decrease limits of detection,18 or calibration in a matrix, if adequate blank extracts are available 19,. 20…”

mentioning

confidence: 99%

Different quantitation approaches for xenobiotics in human urine samples by liquid chromatography/electrospray tandem mass spectrometry

Sancho

Pozo

López

et al. 2002

Rapid Comm Mass Spectrometry

View full text Add to dashboard Cite

The potential of liquid chromatography combined with tandem mass spectrometry (LC/MS/MS) for the determination of pesticide metabolites in human urine at the sub-ppb level is explored. Metabolites from two organophosphorous pesticides, 4-nitrophenol (from parathion and parathion-methyl) and 3-methyl-4-nitrophenol (from fenitrothion), are taken as model analytes to conduct this study. After direct injection of the urine sample (10 microL), different approaches were evaluated in order to achieve correct quantitation of analytes using an electrospray ionisation (ESI) interface. Thus, the feasibility of using external calibration was checked versus the use of different isotope-labeled internal standards. The advantages of applying coupled-column liquid chromatography (LC/LC) as an efficient clean-up without any type of sample manipulation are also discussed. The combination of LC/LC with ESI-MS/MS allows the direct analysis of free metabolites in urine, as the automated clean-up performed by the coupled-column technique is sufficient for the removal of interferences that suppress the ionisation of analytes in the ESI source. Using this procedure with external calibration, good precision and recoveries, and detection limits below 1 ng/mL are reached with analysis run times of around 8 min. The hyphenated technique LC/LC/ESI-MS/MS is proved to be a powerful analytical tool, allowing the rapid, sensitive and selective determination of 4-nitrophenol and 3-methyl-4-nitrophenol in human urine without any sample treatment.

show abstract

mentioning

confidence: 99%

Different quantitation approaches for xenobiotics in human urine samples by liquid chromatography/electrospray tandem mass spectrometry

Sancho

Pozo

López

et al. 2002

Rapid Comm Mass Spectrometry

View full text Add to dashboard Cite

show abstract

“…However, they are rather laborious and time‐consuming, and large volumes of toxic extraction solvents are used. The methods are based on extraction with water‐miscible (Bean & Henion, 1997; Vahl, Graven, & Juhler, 1998; Volmer, 1998; Juhler & Vahl, 1999; Mol et al, 1999, 2000; Startin et al, 1999; Bolygo & Boseley, 2000; Evans et al, 2000b; Hau et al, 2000; Hogenboom et al, 2000; Bester et al, 2001; Castro, Moyano, & Galceran, 2001a; Choi, Hercules, & Gusev, 2001a,b; Pozo et al, 2001; Careri et al, 2002; CEN, 2002; Riedeker et al, 2002; Taylor et al, 2002; Bonmatin et al, 2003) or water‐immiscible solvents (Stout et al, 1998). Those extracts are usually subjected to different clean‐up procedures such as liquid–liquid partitioning (Volmer, 1998; Bester et al, 2001; Choi, Hercules, & Gusev, 2001a,b; Bonmatin et al, 2003), gel permeation (Bester et al, 2001), SPE (Vahl, Graven, & Juhler, 1998; Volmer, 1998; Juhler & Vahl, 1999; Mol et al, 1999; Bolygo & Boseley, 2000; Pozo et al, 2001; Castro, Moyano, & Galceran, 2001a; Choi, Hercules, & Gusev, 2001a,b; Bonmatin et al, 2003), or ion exchange (Hau et al, 2000; Riedeker et al, 2002).…”

Section: Extraction and Isolation Methods From Environmental Andmentioning

confidence: 99%

Environmental and food applications of LC–tandem mass spectrometry in pesticide‐residue analysis: An overview

Picó

Blasco

Font

2003

Mass Spectrometry Reviews

280

150

View full text Add to dashboard Cite

I.Introduction45 II.Pesticide Structures and Properties46 III.Extraction and Isolation Methods from Environmental and Food Samples47 IV.LC/MS/MS Analysis of Pesticides53A. Interfacing Systems53B. Instrumental Aspects57C. Optimization of Chromatographic Mass Spectrometric Conditions57 V.Tandem MS Methods59A. Triple Quadrupole59B. Quadrupole Ion Trap66C. Hybrid Quadrupole TOF (Q‐TOF)71 VI.Performance Characteristics of LC‐Tandem MS for Pesticides72 VII.Applications75 VIII.Conclusions80References81 An overview is given on pesticide‐residue determination in environmental and food samples by liquid chromatography/mass spectrometry/mass spectrometry (LC/MS/MS). Pesticides comprise a large number of substances that belong to many completely different chemical groups, the only common characteristic is that they are effective against pests. They still constitute a challenge in MS because there is no collective pathway for fragmentation. A brief introduction to the theory of tandem MS permits a discussion of which parameters influence the ionization efficiency when the ions are subjected to different actions. Emphasis is placed on the different tandem MS instruments: triple and ion‐trap quadrupoles, and hybrid quadrupole time‐of‐flight (Q‐TOF), including advantages and drawbacks, typical detection limits, and ion signals at low concentrations. The instrumental setup, as well as LC and mass spectrometric experimental conditions, must be carefully selected to increase the performance of the analytical system. The capacity of each instrument to provide useful data for the identification of pesticides, and the possibility to obtain structural information for the identification of target and non‐target compounds, are discussed. Finally, sample preparation techniques and examples of applications are debated to reveal the potential of the current state‐of‐the‐art technology, and to further promote the usefulness of tandem MS. © 2003 Wiley Periodicals, Inc., Mass Spec Rev 23:45–85, 2004

show abstract

“…Liquid chromatography combined with mass spectrometry (LC-MS) is a technique commonly used in the determination of pesticides that have similar physicochemical properties as PGR or used either as pesticides or PGR (e.g., 2.4-D, [20] chlormequat, [21,22] mepiquat, [21,22] and daminozide [23] but also for the determination of various classes of PGR such as auxins, [11,24,25] abscisic acid, [7,12] gibberellins, [11] and cytokinins. [3] Acidic 316 C. J.…”

Section: Introductionmentioning

confidence: 99%

Simultaneous Determination of Different Classes of Plant Growth Regulator in High Water Content Agricultural Products by Liquid Chromatography Tandem Mass Spectrometry and Time of Flight Mass Spectrometry

Anagnostopoulos

Liapis

Haroutounian

et al. 2013

Journal of Liquid Chromatography & Related Technologies

View full text Add to dashboard Cite

Determination of daminozide in apples and apple leaves by liquid chromatography–mass spectrometry

Cited by 30 publications

References 6 publications

Different quantitation approaches for xenobiotics in human urine samples by liquid chromatography/electrospray tandem mass spectrometry

Different quantitation approaches for xenobiotics in human urine samples by liquid chromatography/electrospray tandem mass spectrometry

Environmental and food applications of LC–tandem mass spectrometry in pesticide‐residue analysis: An overview

Simultaneous Determination of Different Classes of Plant Growth Regulator in High Water Content Agricultural Products by Liquid Chromatography Tandem Mass Spectrometry and Time of Flight Mass Spectrometry

Contact Info

Product

Resources

About