Determination of Correlation Times of New Paramagnetic Gadolinium MR Contrast Agents by EPR and<sup>17</sup>O NMR

doi:10.5012/bkcs.2009.30.4.849

Cited by 9 publications

(1 citation statement)

References 20 publications

(32 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…where γ NV = 2π × 28 GHz/T is the NV electron spin gyromagnetic ratio, and τ c is the effective correlation time of the Gd noise spectrum, taken to be 0.36 ns [35]. With a 10 nm deep NV, the simulation result in Fig.…”

Section: Gadolinium-nv Relaxometrymentioning

confidence: 99%

Two-Dimensional Nanoscale Imaging of Gadolinium Spins via Scanning Probe Relaxometry with a Single Spin in Diamond

et al. 2014

View full text Add to dashboard Cite

Spin-labeling of molecules with paramagnetic ions is an important approach for determining molecular structure, however current ensemble techniques lack the sensitivity to detect few isolated spins. In this Letter, we demonstrate two-dimensional nanoscale imaging of paramagnetic gadolinium compounds using scanning relaxometry of a single nitrogen vacancy (NV) center in diamond. Gadopentetate dimeglumine attached to an atomic force microscope tip is controllably interacted with and detected by the NV center, by virtue of the fact that the NV exhibits fast relaxation in the fluctuating magnetic field generated by electron spin flips in the gadolinium. Using this technique, we demonstrate a reduction in the T 1 relaxation time of the NV center by over two orders of magnitude, probed with a spatial resolution of 20 nm. Our result exhibits the viability of the technique for imaging individual spins attached to complex nanostructures or biomolecules, along with studying the magnetic dynamics of isolated spins.

show abstract

Section: Gadolinium-nv Relaxometrymentioning

confidence: 99%

Two-Dimensional Nanoscale Imaging of Gadolinium Spins via Scanning Probe Relaxometry with a Single Spin in Diamond

et al. 2014

View full text Add to dashboard Cite

show abstract

Metal‐Based Nanoparticle Magnetic Resonance Imaging Contrast Agents: Classifications, Issues, and Countermeasures toward their Clinical Translation

Antwi-Baah

Wang

Chen

et al. 2022

Adv Materials Inter

View full text Add to dashboard Cite

Over the years, several imaging techniques have been developed to improve alreadyexisting ones, thus, overcoming the obstacles that previous ones failed to overcome. Recently, much energy has been put into developing tools that complement the ability of the current imaging techniques. Imaging probe or contrast agent is one of the well-known tools in this category, which enhance the conspicuousness of images. Researchers have taken the opportunity to work tirelessly on developing imaging probes, which have gone a long way in attaining biological and functional image details of a biological system when used alongside existing imaging techniques. With the advantage of displaying a more detailed view for analyzing biological information and diagnosing diseases, imaging probes are undoubtedly a significant research field in biological and medical sciences.Molecular imaging, a term describing the visualization of specific molecules and molecular transformations that occur during disease activity in a living system using radiological and nuclear medicine, [2] has recently received enormous attention. A tissue or organ is diseased when it depicts characteristics that deviate from its normal functionality or organization. The diseased condition is stimulated by many biochemical processes involving internal and external stimuli from within the cell. Molecular imaging serves as a diagnostic tool for detecting abnormal disease molecules early because it can examine the biochemical adjustments as a normal tissue mutates into a diseased one. Representative imaging techniques include magnetic particle imaging (MPI), [3] positron emission tomography (PET), single-photon emission computed tomography (SPECT), optical imaging, magnetic resonance imaging (MRI), computed tomography (CT) and, ultrasound. [4] These imaging techniques are noninvasive diagnostic platforms that bridge the gap between molecular biology and molecular medicine. They allow examining a living organism to verify effects on multiple organ systems in vivo and help diagnose diseases at preclinical stages. These imaging techniques employ tracers or contrast agents to improve sensitivity. MPI is a tracer imaging modality that instantaneously quantifies the concentration and Metal-based nanoparticles, especially gadolinium, manganese, and iron, have gained ground in the research of magnetic resonance imaging (MRI) contrast agents. Over the years, contrast agents based on these paramagnetic and superparamagnetic nanomaterials have merited keen attention in the biomedical field due to their desired properties such as sizeable magnetic susceptibility, tunable size, easy surface functionalization, low toxicity, etc. Gadolinium-based chelates are the traditional MRI contrast agents in the clinic but require improved relaxivities and pharmacokinetics. Nanoparticles possess a larger surface area, demonstrate a longer retention time in the body, and allow the conjugation of several functional molecules to enhance tumor targeting, making them more advantageous. The pursuit o...

show abstract

Blood‐Pool and Targeting MRI Contrast Agents: From Gd‐Chelates to Gd‐Nanoparticles

2012

View full text Add to dashboard Cite

Magnetic resonance imaging (MRI) is a powerful and noninvasive diagnostic technique of the human anatomy, physiology, and pathophysiology on the basis of superior spatial resolution and contrast. MRI is useful in providing anatomical and functional images of the human body. A large number of MRI techniques are performed employing gadolinium III [GdIII] complexes to enhance image contrast by increasing the water proton relaxation rate in the body. Despite their wide and successful application in clinic, however, conventional GdIII‐based low‐molecular weight contrast agents (CAs) are mostly extracellular contrast agents (ECCAs) exhibiting rapid extravasation from the vascular space. As a result, the time window for imaging is considerably reduced, thus limiting acquisition of high‐resolution images. To overcome such limitations inherent to ECCAs, the necessity and the demand for the development of a new class of MRI CAs with functions including blood‐pool and organ (or tumor)‐targeting have risen recently. This microreview deals with our recent efforts on the design and the synthesis of new Gd‐chelates and Gd nanoparticles (GdNPs) for use as blood‐pool and organ/tumor‐targeting MRI CAs. We also consider properties such as high r1 relaxivity and high thermodynamic, kinetic, and biostabilities.

show abstract

Determination of Correlation Times of New Paramagnetic Gadolinium MR Contrast Agents by EPR and¹⁷O NMR

Cited by 9 publications

References 20 publications

Two-Dimensional Nanoscale Imaging of Gadolinium Spins via Scanning Probe Relaxometry with a Single Spin in Diamond

Two-Dimensional Nanoscale Imaging of Gadolinium Spins via Scanning Probe Relaxometry with a Single Spin in Diamond

Metal‐Based Nanoparticle Magnetic Resonance Imaging Contrast Agents: Classifications, Issues, and Countermeasures toward their Clinical Translation

Blood‐Pool and Targeting MRI Contrast Agents: From Gd‐Chelates to Gd‐Nanoparticles

Contact Info

Product

Resources

About

Determination of Correlation Times of New Paramagnetic Gadolinium MR Contrast Agents by EPR and17O NMR

Cited by 9 publications

References 20 publications

Two-Dimensional Nanoscale Imaging of Gadolinium Spins via Scanning Probe Relaxometry with a Single Spin in Diamond

Two-Dimensional Nanoscale Imaging of Gadolinium Spins via Scanning Probe Relaxometry with a Single Spin in Diamond

Metal‐Based Nanoparticle Magnetic Resonance Imaging Contrast Agents: Classifications, Issues, and Countermeasures toward their Clinical Translation

Blood‐Pool and Targeting MRI Contrast Agents: From Gd‐Chelates to Gd‐Nanoparticles

Contact Info

Product

Resources

About

Determination of Correlation Times of New Paramagnetic Gadolinium MR Contrast Agents by EPR and¹⁷O NMR