Determination of compatibility and stability of drugs used in palliative care

Abstract

The results suggest that the combination of different concentrations of morphine hydrochloride with haloperidol, metoclopramide hydrochloride, atropine sulphate, butylhyoscine bromide or ranitidine hydrochloride do not affect their stability when stored for 7 days up to 30 degrees C under the influence of ambient light. However, more robust stability-indicating methods are required to confirm these results. The proposed method is more useful for identifying combinations that are clearly incompatible than to identify those that are compatible.

Stability and compatibility of binary mixtures of morphine hydrochloride with hyoscine-n-butyl bromide

“…The physical compatibility and/or stability of morphine combined with adjuvant drugs in solution destined to subcutaneous infusion has been widely studied [11,12,13,14,15,16,17,18,19,20] although in some studies only visual inspection of the samples was performed, providing information on the physical compatibility but not on the chemical compatibility or chemical stability of the drugs in the mixture. Moreover, studies have not yet been done regarding the combination of morphine hydrochloride and hyoscine-N-butyl bromide in solution in which the quantification of both drugs was performed by HPLC.…”

Stability studies of binary and ternary mixtures containing morphine, midazolam, levomepromazine and hyoscine butylbromide for parenteral administration

“…pH values of 4.5–5.5 were found by Schrijvers et al . when hyoscine butylbromide was combined with different morphine concentrations …”

Tramadol and hyoscine N-butyl bromide combined in infusion solutions: compatibility and stability

“…Hyoscine N-butyl bromide was found to be compatible when combined in infusion solutions with fentanyl [23], diamorphine, octreotide [24], or morphine hydrochloride [25]. However, hyoscine N-butyl bromide precipitates with haloperidol lactate [26] or with cyclizine [24] at certain concentrations when combined in saline solution.…”