Determination of codeine in human plasma by high-performance liquid chromatography with fluorescence detection

Simultaneous voltammetric and amperometric determination of morphine and codeine using a chemically modified-palladized aluminum electrode

“…Various analytical methods including gas chromatography [2][3][4] chemi-luminescent [5][6][7] and high performance liquid chromatography [8][9][10] were reported for CO determination. However, these methods are time consuming or solvent-usage intensive.…”

A Review of Analytical Methods for Codeine Determination

“…Reversed-phase HPLC (RP-HPLC) systems with C-18 or C-8 columns have been reported for the determination of codeine/codeine phosphate and other pharmaceutical active ingredients in dosage forms [83][84][85]. In addition, these systems have also been used to detect codeine and its active metabolites in biological samples [86,87]. C-18 columns are popular in RP-HPLC systems due to their relatively high organic/carbon contents, allowing for better interaction between the organic solutes/analytes with the stationary phase [88].…”

Simultaneous determination of codeine, ephedrine, guaiphenesin and chlorpheniramine in beagle dog plasma using high performance liquid chromatography coupled with tandem mass spectrometric detection: Application to a bioequivalence study

“…Several methods have been reported for the determination of codeine, ephedrine, guaiphenesin and chlorpheniramine individually or combination with others, such as high performance liquid chromatography (HPLC) with ultraviolet (UV) detection [3] or fluorescence detection [4,5], even with GC-MS, HPLC-MS, HPLC-MS/MS [6][7][8][9][10][11][12]. CCPS contains four analytes which are highly different polarities and wide range of concentrations in plasma after an oral dose, it is desirable to develop an analytical method to allow four analytes to be quantified simultaneously in beagle dog plasma.…”