Determination of clinical efficiency of deproteinized dialysate from blood of milk-fed calves after endoprosthetics in patients with ventral hernias

Abstract

Aim. To study the influence of deproteinized dialysate from blood of milk-fed calves on the type of exudative discharge and dynamics of inflammatory reaction after hernia repair with plastics of the anterior abdominal wall with hernioendoprosthesis of polypropylene.
 Materials and Methods. The study involved 59 patients being on stationary treatment in the surgical department of Kursk Regional Clinical Hospital. Patients were hospitalized for the herniation of small or medium dimension. The patients were divided to two groups: the main (n=30) and control (n=29) groups. After endoprosthetics, the patients of the control group were given complex conservative treatment. The patients of the main group, besides standard treatment, were administered deproteinized dialysate from blood of milk-fed calves intravenously in drips 10 ml + 200 ml of 0.9% sodium chloride solution within 7 days. For cytological examination and determination of the type of cytograms, the traumatic discharge was collected and analyzed using the method of M.F. Kamaev and M.A. Palthsev.
 Results. Cytomorphometric examination was conducted on the third, fifth and seventh day after endoprosthetics with the aim of studying dynamic changes. Determination of cell composition and also of its changes characteristic of each studied period, was necessary for obtaining further information characterizing inflammatory process in the region of placement of the endoprosthesis. After endoprosthetics in patients who were administered hemodialysate, the inflammatory reaction was less pronounced than in patients who did not receive the preparation. This was associated with a more dynamic change of stages of the inflammatory process. In patients of the main group who received deproteinized dialysate, regenerative type of inflammation first appeared on the fifth day and made 6.9%; by the seventh day the share of patients with the regenerative type rose to 17.5%, while in the patients of the control group no regeneration stage was observed in both periods.
 Conclusion. Analysis of the efficiency of influence of hemodialysate on the inflammatory reaction in plastics of the anterior abdominal wall with polypropylene endoprosthesis evidences faster course of all stages of inflammation and reduction of its intensity by 10%.

Studying the influence of Solcoseryl drug and vitamin C on the inflammatory reaction and proliferation of fibroblastic cells in the filed of polypropylene endoprosthesis implantation

“…During implantation of a hernia endoprosthesis, wound healing proceeds successively through all the stages of wound process development. However, a response of tissues to the endoprosthesis as a foreign body can provoke some repair difficulties, for example, extension of the exudative phase of inflammation and increased exudation (Ivanov et al 2020).…”

“…(Guessasma et al 2017;Laronda et al 2017;Graf et al 2018;Aleksandrushkina et al 2019;Ballard et al 2019;Stepenko et al 2019). Today the use of endoprostheses with coatings based on a substance that influences the collagen formation process and accelerates the wound healing process is most promising (Ivanov et al 2020).…”

“…This drug belongs to several pharmacological groups: antihypoxants and antioxidants, angioprotectors and microcirculation correctors, regenerants and reparants. Solcoseryl contains a large number of active substances that supply cells with high-energy phosphates by improving glucose transport, aerobic glycolysis and oxidative phosphorylation, reduce degenerative processes in tissues and improve reparative ones, and therefore can correct various phases of wound repair and affect collagen formation (Lazarenko et al 2016;Ob'edkov et al 2019;Ivanov et al 2020;Register of Medicines of Russia 2021a, b). The drug has a systemic effect when injected intravenously or intramuscularly and can be used topically as ointment or gel, the dosage depends on a nosological form of the disease.…”

“…Thus, the use of collagen-stimulating coatings will allow influencing repair processes topically, reducing exudation, increasing proliferation and formation of mature collagen fibers (Tappa et al 2017;Tappa et al 2018;Ivanov et al 2020).…”