Determination of ciprofloxacin and enrofloxacin in edible animal tissues by terbium-sensitized luminescence†

Hernández-Arteseros, J. A.; Compañó, R.; Prat, M.D.

doi:10.1039/a805160g

Cited by 47 publications

(26 citation statements)

References 16 publications

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“…The plurality of these interactions indicates the problems of sensors including lanthanide complexes as receptors for the specific recognition of a certain analyte. The same is the case for free lanthanide ions that have been presented for the luminescent determination of pharmaceutically active compounds such as antibiotics [15][16][17]. Nevertheless, Molina-Diaz et al have Scheme 6 Europium complex as monomer for the preparation of humidity sensitive luminescent copolymers described a sensor for flow-injection analysis (FIA) that can be applied to the determination of p-aminobenzoic acid in pharmaceutical preparations [113].…”

Section: Sensors For Small Organic Compoundsmentioning

confidence: 92%

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Luminescent Chemical and Physical Sensors Based on Lanthanide Complexes

Spangler

Schäferling

2010

Lanthanide Luminescence

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Luminescent lanthanide complexes (LLCs) are versatile probes for the determination of a variety of analytes such as metal ions, anions, hydrogen peroxide, ATP, pH, or oxygen. Antenna chromophores have been introduced as ligands for sensitizing lanthanide emission. The ligand system or the lanthanide ion can act as receptors for reversible binding of analytes. Thus, the response of luminescence emission can occur via ligand or metal-centered processes, which will both be discussed. LLCs, particularly Eu 3+ and Tb 3+ complexes, have been incorporated in solid state matrices, e.g., polymer hydrogels or silica to obtain optical sensor layers. A selection of such sensitive materials will be outlined, including sensors for the analytically relevant parameters oxygen, pH, hydrogen peroxide, humidity, and temperature.

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Section: Sensors For Small Organic Compoundsmentioning

confidence: 92%

“…Furthermore, this overview does not cover lanthanide systems in which the analyte itself actuates as sensitizer for the lanthanide ion. This principle can be used for the determination of antibiotics in aqueous solution [15][16][17].…”

Section: Classification Of Luminescent Lanthanide Probesmentioning

confidence: 99%

Luminescent Chemical and Physical Sensors Based on Lanthanide Complexes

Spangler

Schäferling

2010

Lanthanide Luminescence

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“…Analytical methods described in the literature for the analysis of quinolones in foods include instrumental techniques (Hernández-Arteseros et al 1998;Rose et al 1998;Roybal et al 2002), rapid immunological techniques (Tittlemier et al 2008;Scortichini et al 2009) and microbial methods (Currie et al 1998;Pikkemaat et al 2007;Fuselier et al 2000;Calderón et al 1996;Myllyniemi et al 2001;Cantwell and O'keeffe 2006;Gaudin et al 2009). …”

Section: Introductionmentioning

confidence: 99%

Performance of a New Microbial Test for Quinolone Residues in Muscle

Sanz¹,

Mata²,

Condón

et al. 2010

Food Anal. Methods

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Concerns regarding the presence of drug residues in foods include allergic reactions, toxicity, technological problems in fermented products and the development of antibiotic resistance in human pathogens. The analysis of antimicrobial residues in foods is generally carried out, in a first step, through microbiological screening tests. These tests commonly use Geobacillus stearothermophilus as target specie but show a low ability to detect quinolones. The goal of our study was to evaluate the performance of a new microbiological test (Equinox) for detection of quinolone residues in muscle. The kit contains an ampoule with a standardized number of freeze-dried Escherichia coli and must be diluted with a specific detection medium containing a redox indicator. Microbial growth will modify the redox potential of the medium being observed through a colour change (from blue to brown/orange). Equinox limits of detection for most of tested quinolones (enrofloxacin, norfloxacin, sarafloxacin, marbofloxacin, ciprofloxacin, danofloxacin and difloxacin) were below or around maximum residue limit (MRL) UE and CCβ values obtained corresponded with the determined sensitivities. In contrast, flumequine could not be detected at MRL UE levels. Moreover, Equinox displayed a low sensitivity to other antimicrobials. Sensitivity data obtained in vitro were consistent when testing incurred muscle samples. Matrix constituents, test batch and animal species did not affect the performance of the test. Equinox could be easily automated enabling a large numbers of simultaneous analysis, and a photometric reading can be applied for a precise interpretation. The results obtained in this study prove that Equinox is a useful tool when screening for quinolone residues or can be combined with other methods for screening of unknown samples.

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“…Most of them use liquid chromatography (LC) [12 -23, 30], some of which are applied in tandem with a mass spectrometric system for confirmation reasons [15 -18, 23]. Other techniques reported include high-performance thin layer chromatography (HPTLC) [24], capillary electrophoresis (CE) [25], and terbium-sensitized luminescence [26]. Reported detection techniques include fluorescence detection characterized by selectivity and sensitivity [12 -14, 16, 21 -22], as well as UV absorbance detection characterized by sensitivity and versatility [11, 14, 19 -20, 24 -25].…”

Section: Introductionmentioning

confidence: 99%

Determination of fluoroquinolones in edible animal tissue samples by high performance liquid chromatography after solid phase extraction

2005

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In the present work, a rapid, accurate, and sensitive method has been developed for the quantitative determination of five fluoroquinolones (enoxacin, ofloxacin, norfloxacin, ciprofloxacin, and enrofloxacin) in edible animal tissues (muscle tissue, liver, kidney, and eggs). The separation was accomplished on an Inertsil (250 x 4 mm) C8, 5 microm, analytical column, at ambient temperature within 15 min. The mobile phase consisted of a mixture of citric acid (0.4 mol L(-1))-CH3OH-CH3CN (87:9:4% v/v). UV detection at 275 nm yielded the following limits of detection: 100 pg per 20 microL injected volume for enoxacin, norfloxacin, and ciprofloxacin, 20 pg for ofloxacin, and 200 pg for enrofloxacin. Peaks in real samples were identified by means of a photodiode array detector. The method was validated in terms of intra-day (n = 8) and inter-day (n = 8) precision and accuracy. Tissue samples were purified from endogenous interference by solid-phase extraction using Oasis HLB cartridges. The solid-phase extraction protocol was optimized in terms of retention and elution. Recovery rates at fortification levels of 40, 60, and 80 ng/g ranged from 82.5% to 111.1%. The applicability of the method was examined using real samples from a chicken treated orally with the five studied fluoroquinolones.

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Determination of ciprofloxacin and enrofloxacin in edible animal tissues by terbium-sensitized luminescence†

Cited by 47 publications

References 16 publications

Luminescent Chemical and Physical Sensors Based on Lanthanide Complexes

Luminescent Chemical and Physical Sensors Based on Lanthanide Complexes

Performance of a New Microbial Test for Quinolone Residues in Muscle

Determination of fluoroquinolones in edible animal tissue samples by high performance liquid chromatography after solid phase extraction

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