Determination of ciprofibrate in human plasma by high-performance liquid chromatography

The influence of renal insufficiency and haemodialysis on the kinetics of ciprofibrate.

“…Concentrations of total unchanged ciprofibrate were measured in plasma and urine using the high-performance liquid chromatographic method of Park et al (1982) with minor modifications. Briefly, to 1 ml of the biological sample, a ciprofibrate analogue ([(dichloro-2,2-phenyl-3-cyclopropyl) -phenoxy] -2methyl-2-propionic acid) was added as the internal standard.…”