Determination of cinnarizine in pharmaceutical preparations by spectrophotometry, atomic absorption spectrometry and potentiometry

Hassan, Saad S. M.; Abbas, Alaa B.; Elmosallamy, Mohamed A. F.

doi:10.1007/bf01242192

Cited by 12 publications

(6 citation statements)

References 10 publications

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“…It is also effective for treating nausea and vomiting 1 .The drug is official in Indian and British pharmacopoeia and estimated by potentiometric titration and liquid chromatography methods 2,3 . Literature survey revealed potentiometry titration and simple spectrophotometry methods for determination of CIN alone in pharmaceutical dosage forms as well as in biological fluids 4,5 . Further a RP-HPLC method is available for the determination of CIN in combination with other drugs 6 .…”

Section: Cinnarizine (Cin) Iupac Name 1-(diphenylmethyl)-4-(3-mentioning

confidence: 99%

Validated Rp-HPLC Method for Simultaneous Estimation of Cinnarizine and Domperidone in Bulk and Pharmaceutical Dosage Form

M¹,

A²

2013

J Pharm Sci Innov

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A new simple, precise, accurate and selective RP-HPLC method has been developed and validated for simultaneous estimation of cinnarizine (CIN) and domperidone (DOM) in tablet dosage form. The method was carried out on a C-18 (250mm × 4.6mm i.d, 5µm) column with a mobile phase consisting of methanol and acetonitrile in the ratio (70:30 v/v) and flow rate of 1.0 mL min -1 . The detection was carried out at 270 nm. The retention time for CIN and DOM were found to be 3.389 and 4.793 min respectively. The CIN and DOM followed linearity in the concentration range of 40-160 μg mL -1 and 45-105 μg mL -1 with r 2 = 0.999. The amount of both drugs estimated by the proposed method was found to be in good agreement with label claim. The developed method was validated for precision, accuracy, sensitivity, robustness and ruggedness. The developed method can be used for routine analysis of titled drugs in combination in the tablet formulations.

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Section: Cinnarizine (Cin) Iupac Name 1-(diphenylmethyl)-4-(3-mentioning

confidence: 99%

Validated Rp-HPLC Method for Simultaneous Estimation of Cinnarizine and Domperidone in Bulk and Pharmaceutical Dosage Form

M¹,

A²

2013

J Pharm Sci Innov

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“…Monitoring of cinnarizine in biological fluids has been carried out mainly by HPLC with UV 3 or fluorescence detection. 4 In pharmaceutical preparations, CNR is assayed by different methods including GC, 5 HPLC, [6][7][8] HPTLC, 9 electrochemical [10][11][12] and spectrophotometric methods. [13][14][15][16][17] Studies of the stability of CNR were also carried out spectrophotometrically.…”

Section: Cinnarizine (Cnr) Is Chemically Called (E)-(diphenylmethyl)-mentioning

confidence: 99%

Determination of Cinnarizine in Pure and Pharmaceutical Formulations

Devagondanahalli

Shaikh

Seetharamappa

et al. 2007

J Chinese Chemical Soc

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Two simple, rapid and sensitive extractive spectrophotometric methods have been developed for the assay of cinnarizine (CNR) in pure and pharmaceutical formulations. The methods are based on the formation of chloroform soluble ion-association complexes of CNR with thymol blue (TB) and with cresol red (CR) in NaOAc-AcOH buffer of pH 3.6 for TB and in KCl-HCl buffer of pH 1.6 for CR with absorption maxima at 405 nm and at 403 nm for TB and CR, respectively. Reaction conditions were optimized to obtain the maximum color intensity. The systems obeyed Beer's law in the range of 0.6-15.8 and 0.8-16.6 mg mL -1 for TB and CR, respectively. Various analytical parameters have been evaluated and the results have been validated by statistical data.

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“…[5][6][7] Uma revisão na literatura revela que existem inúmeros trabalhos sobre métodos analíticos para determinação de cinarizina em formulações farmacêuticas. Os métodos descritos empregam as técnicas de eletroforese capilar, 8 eletrocromatografia capilar, 9 cromatografia gasosa, 10,11 cromatografia líquida de alta eficiência, [12][13][14][15][16][17][18][19] cromatografia em camada delgada, 18 cromatografia em camada delgada de alta eficiência, 20,21 métodos eletroquímicos, [22][23][24][25][26] espectrofotometria, 16,17,19,[26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41] quimioluminescência, 42 fluorimetria 43,44 e espectrodensitometria. 19 Além dos métodos mencionados acima, ensaios de dissolução para comprimidos de cinarizina utilizando detecção potenciométrica ou por cromatografia líquida de alta eficiência também são descritos.…”

Section: Introductionunclassified

Estabelecimento de condições para ensaio de dissolução de cápsulas de cinarizina empregando planejamento fatorial

Gehring¹,

Santos²,

Pereira³

et al. 2011

Quím. Nova

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Recebido em 5/7/10; aceito em 21/10/10; publicado na web em 26/1/11 ESTABLISHMENT OF DISSOLUTION TEST CONDITIONS FOR CINNARIZINE IN PHARMACEUTICAL CAPSULES USING FACTORIAL DESIGN. This work describes the establishment of dissolution test conditions for 75 mg cinnarizine capsules using a multivariate approach. A 2 3 full factorial design was carried out to achieve the best conditions and HCl 0.1 mol L -1 as dissolution medium, basket as apparatus at 100 rpm and collect time at 30 min were considered adequate. The quantification was carried out by spectrophotometry at 251 nm. Both dissolution procedure and analytical method were validated and all parameters were within the acceptable limits. Since there is no official monograph for this pharmaceutical product, this dissolution test could be applied for quality control routine.

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Determination of cinnarizine in pharmaceutical preparations by spectrophotometry, atomic absorption spectrometry and potentiometry

Cited by 12 publications

References 10 publications

Validated Rp-HPLC Method for Simultaneous Estimation of Cinnarizine and Domperidone in Bulk and Pharmaceutical Dosage Form

Validated Rp-HPLC Method for Simultaneous Estimation of Cinnarizine and Domperidone in Bulk and Pharmaceutical Dosage Form

Determination of Cinnarizine in Pure and Pharmaceutical Formulations

Estabelecimento de condições para ensaio de dissolução de cápsulas de cinarizina empregando planejamento fatorial

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