Determination of chlormequat and mepiquat in pear, tomato, and wheat flour using on-line solid-phase extraction (Prospekt) coupled with liquid chromatography–electrospray ionization tandem mass spectrometry

Riediker, Sonja; Obrist, Heinrich; Varga, Natalia; Stadler, Richard H.

doi:10.1016/s0021-9673(02)00737-9

Cited by 57 publications

(33 citation statements)

References 28 publications

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“…For most previously published LC-MS or LC-MS/MS methods, a C 8 , C 18 or silica-based reversed-phase column was usually applied with aqueous HFBA (15-20 mM) and methanol or acetonitrile as mobile phases for the analyses of CQ and MQ [1,2,6,11,19,20]. To remove the need for the use of the ion-pair reagent, HFBA, which can pollute the MS, the CAPCELL PAK CR 1:4 (SCX:C18 = 1:4) column containing strong cationic exchange resins and C18 was tested in this study.…”

Section: Lc-ms Methods Developmentmentioning

confidence: 99%

An improved method for analyzing chlormequat and mepiquat in source waters by solid-phase extraction and liquid chromatography–mass spectrometry

Jin

et al. 2010

Analytica Chimica Acta

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a b s t r a c tA liquid chromatography-mass spectrometry (LC-MS) method for the identification and quantification of chlormequat (CQ) and mepiquat (MQ) in source waters with high sensitivity and specificity was established using WCX cartridges (150 mg/6 mL) for pre-concentration of the samples and using the CAPCELL PAK CR 1:4 (2.0 mm × 150 mm 5 m, SCX:C18 = 1:4) column containing strong cationic exchange resins and C18 for separation. The method could solve the problem for pre-concentrating ionic compounds from water samples and avoid the MS instrument fouling problem accompanied with the use of ion-pair reagents. After the optimization of analytical conditions, quantification was achieved in the positive electrospray ionization mode using selected ion monitoring. The samples were analyzed with multi-channel mode with quantification performed at 30 V cone voltage to ascertain the sensitivity and qualitative analysis performed at 60 V cone voltage simultaneously. The method detection limits (MDLs) of CQ and MQ in source water were determined to be 14 and 22 ng L −1 . Finally, the method was used to quantify CQ and MQ in several source waters, which gave a level ranging from below the quantitation limit to 28 ng L −1 .

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Section: Lc-ms Methods Developmentmentioning

confidence: 99%

An improved method for analyzing chlormequat and mepiquat in source waters by solid-phase extraction and liquid chromatography–mass spectrometry

Jin

et al. 2010

Analytica Chimica Acta

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“…In particular, liquid chromatography (LC) coupled to triple quadrupole tandem mass analysers (QqQ) is generally regarded as the most widely applied technique for multi-residue analysis of pesticides. This is principally due to its wide compound coverage and high qualitative and quantitative analytical performance [7][8][9]12,13,15,17,18,20,25,28]. Although QqQ provides excellent sensitivity and specificity, it also has limited structural information and does not identify non-target compounds [5,19,27].…”

Section: Introductionmentioning

confidence: 99%

QqQ and Q-TOF liquid chromatography mass spectrometry direct aqueous analysis of herbicides and their metabolites in water

Lucini

Pellegrino

Cimino

et al. 2015

International Journal of Mass Spectrometry

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“…These methods suffer from some drawbacks that cause false positives, especially at low residual levels. Recently, some papers have reported analysis of CCC residues in fruit and grain samples using the LC-MS-MS method [4][5][6][7][8][9]. These methods describe reversed-phase LC or ion-exchange LC coupled to MS-MS for determination of CCC.…”

Section: Introductionmentioning

confidence: 99%

Uncertainty Analysis of Chlormequat Residue in Fruits by LC–MS–MS

Tian

2011

Chromatographia

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A method for determination of chlormequat (CCC) residue in fruits by liquid chromatography-tandem mass spectrometry (LC-MS-MS) was developed. Residue of CCC was extracted from samples with methanol-water (v/v, 1:1) containing 1.0% acetic acid, cleaned up by strong cationic exchange (SCX) cartridge, and then determined by LC-MS-MS. The method showed good linearity over the concentration range 0.002-5.0 mg kg -1 with correlation coefficient above 0.997. The limit of detection (LOD) and limit of quantitation (LOQ) for CCC were 5 9 10 -4 mg kg -1 (S/N = 3) and 0.002 mg kg -1 (S/N = 10), respectively. Recoveries for CCC at three spiked levels (0.025, 0.050, and 0.20 mg kg -1 ) were in the range 80-102%. Estimation of measurement uncertainty was calculated for CCC at the level of 0.025 mg kg -1 in fruits. The results demonstrated that the uncertainty of recovery was the main contribution to the combined standard uncertainty. The relative combined standard uncertainties associated with the method ranged from 11 to 13%, depending on the sample matrices.

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Determination of chlormequat and mepiquat in pear, tomato, and wheat flour using on-line solid-phase extraction (Prospekt) coupled with liquid chromatography–electrospray ionization tandem mass spectrometry

Cited by 57 publications

References 28 publications

An improved method for analyzing chlormequat and mepiquat in source waters by solid-phase extraction and liquid chromatography–mass spectrometry

An improved method for analyzing chlormequat and mepiquat in source waters by solid-phase extraction and liquid chromatography–mass spectrometry

QqQ and Q-TOF liquid chromatography mass spectrometry direct aqueous analysis of herbicides and their metabolites in water

Uncertainty Analysis of Chlormequat Residue in Fruits by LC–MS–MS

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