Determination of chlorinated dibenzofurans in Kanechlors and “Yusho Oil”

Nagayama, Junya; Kuratsune, Masanori; Masuda, Yoshito

doi:10.1007/bf01686189

Cited by 149 publications

(31 citation statements)

References 4 publications

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“…Based on the results of this study, we also strongly recommend that it be considered as a fundamental therapeutic supplementation for patients with Yusho disease, which is PCDF intoxication [35][36]. Chlorella is likely to reduce the PCDF body burden of such patients.…”

Section: Discussionmentioning

confidence: 78%

Effects of Chlorella Supplementation on Decreasing Concentrations of Dioxins in the Blood of Pregnant Japanese Women

Nagayama¹,

Maruyama²,

Uchikawa³

et al. 2015

Clinics Mother Child Health

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Adverse health consequences from prenatal, perinatal and postnatal exposure to background levels of dioxins in the environment, including polychlorinated dibenzo-p-dioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs), have been reported. In order to prevent or reduce such health risks, it is important to decrease maternal exposure to dioxins. This study investigated the effect of maternal supplementation with Chlorella on dioxin concentration levels in the blood during pregnancy. Twenty healthy pregnant women participated in the study. Ten received 6 g of Chlorella daily from gestational week 16-20 until the day of delivery (Chlorella group); ten others did not (control group). The blood PCDFs and PCDD/DFs concentrations in the Chlorella group significantly decreased during the supplementation period, from 2.20 ± 1.66 to 1.00 ± 0.61 pg-TEQ/g lipid (p<0.05) and from 5.48 ± 4.01 to 3.38 ± 1.96 pg-TEQ/g lipid ( p<0.05), respectively. The levels of dioxins in the control group did not change significantly. These results suggest that Chlorella supplementation may be effective in reducing dioxin exposure in pregnant woman.

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Section: Discussionmentioning

confidence: 78%

Effects of Chlorella Supplementation on Decreasing Concentrations of Dioxins in the Blood of Pregnant Japanese Women

Nagayama¹,

Maruyama²,

Uchikawa³

et al. 2015

Clinics Mother Child Health

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“…The latest studies on Yusho have revealed that the rice oil involved was contaminated with PCQs and highly toxic PCDFs (14)(15)(16). PCDFs were detected in tissues of Japanese Yusho patients (17), and Kashimoto et al (18) detected them in the blood of "fresh" Taiwanese patients though they could not be detected in "old" Japanese Yusho patients.…”

Section: Discussionmentioning

confidence: 99%

Surveys of Workers Occupationally Exposed to PCBs and of Yusho Patients

Takamatsu¹,

Oki²,

Maeda³

et al. 1985

Environmental Health Perspectives

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Surveys of workers occupationally exposed to polychlorinated biphenyls (PCBs) in the production of thread or of paint, and of Yusho patients were carried out from 1973 to 1982. PCB concentrations in the plasma of the workers ranged from 2 to 521 ppb, and some showed higher PCB levels in the plasma than typical Japanese Yusho patients. Gas chromatographic patterns of plasma PCBs of the workers with high PCB levels were shown to match the patterns of the PCBs to which they had been exposed in the workplace. Japanese Yusho children showed remarkable decrease with time, but no such decrease was observed in the Yusho adults and the workers.Polychlorinated quaterphenyls (PCQs) were detected in the blood of typical Japanese and Taiwanese Yusho patients, but PCQ levels in the plasma of the workers were below the detection limit of 0.02 ppb.Clinical findings and subjective complaints of the workers were usually slight compared with typical Yusho patients, though some of them had mild dermal manifestations and their PCB levels were suspected to be related to serum triglyceride values.On the basis of these results, we discussed the relationship between the health status of the subjects and their contamination with PCBs or related compounds.

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“…(7) investigated the formation and measured concentrations of polychlorinated dibenzofurans (PCDFs) and polychlorinated dibenzodioxins (PCDDs) in the exhaust emissions from incinerators. These same compounds, however, have been identified in PCB samples before they were incinerated (8)(9)(10), indicating that they may be found in the emissions from a poorly designed incinerator presumably because residence time, oxygen supply, turbulence, atomization, or some combination of all these factors in the reactor zone were inadequate. In this review, performance data of different incinerator designs will be analyzed to identify critical design criteria that ensure high percentages of destruction of PCBs and their contaminants and that provide conditions that do not favor formation of other toxic combustion products.…”

Section: Introductionmentioning

confidence: 92%

Waste Disposal Technologies for Polychlorinated Biphenyls

Piver¹,

Lindstrom²

1985

Environmental Health Perspectives

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Improper practices in the disposal of polychlorinated biphenyl (PCB) wastes by land burial, chemical means and incineration distribute these chemicals and related compounds such as polychlorinated dibenzofurans (PCDFs) and polychlorinated dibenzodioxins (PCDDs) throughout the environment. The complete range of methods for disposal that have been proposed and are in use are examined and analyzed, with emphasis given to the two most commonly used methods: land burial and incineration.The understanding of aquifer contamination caused by migration of PCBs from subsurface burial sites requires a description of the physical, chemical and biological processes governing transport in unsaturated and saturated soils. For this purpose, a model is developed and solved for different soil conditions and external driving functions. The model couples together the fundamental transport phenomena for heat, mass, and moisture flow within the soil.To rehabilitate a contaminated aquifer, contaminated groundwaters are withdrawn through drainage wells, PCBs are extracted with solvents or activated carbon and treated by chemical, photochemical or thermal methods. The chemical and photochemical methods are reviewed, but primary emphasis is devoted to the use of incineration as the preferred method of disposal. After discussing the formation of PCDFs and PCDDs during combustion from chloroaromatic, chloroaliphatic, as well as organic and inorganic chloride precursors, performance characteristics of different thermal destructors are presented and analyzed. To understand how this information can be used, basic design equations are developed from governing heat and mass balances that can be applied to the construction of incinerators capable of more than 99.99% destruction with minimal to nondetectable levels of PCDFs and PCDDs.

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Determination of chlorinated dibenzofurans in Kanechlors and “Yusho Oil”

Cited by 149 publications

References 4 publications

Effects of Chlorella Supplementation on Decreasing Concentrations of Dioxins in the Blood of Pregnant Japanese Women

Effects of Chlorella Supplementation on Decreasing Concentrations of Dioxins in the Blood of Pregnant Japanese Women

Surveys of Workers Occupationally Exposed to PCBs and of Yusho Patients

Waste Disposal Technologies for Polychlorinated Biphenyls

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