Determination of chlordane in foods by gas chromatography

Amyotrophic Lateral Sclerosis-Associated Persistent Organic Pollutant cis-Chlordane Causes GABAA-Independent Toxicity to Motor Neurons, Providing Evidence toward an Environmental Component of Sporadic Amyotrophic Lateral Sclerosis

“…Using the EPA-allowable levels and the average U.S. adult weight of 180 pounds (81.6 kg), and assuming the proven bioaccumulation in fat, , an adult would have to drink chlordane contaminated water for ∼603 days to reach our measured EC50 of 12 μM (see calculation in the Supporting Information). With levels of chlordane in the environment measured far above 2 ppb (for example, 530 ppb in soil measured in 2018) and the biomagnification due to the rapid accumulation of cis- chlordane into fats, , it is highly probable that over a lifetime, a person could reach the cis- chlordane levels measured here.…”

“…Although cis -chlordane was banned 34 years ago, it persists in our environment and accumulates in the fat of lower animals posing an immediate danger to humans and other predators. , The Environmental Protection Agency (EPA) monitors chlordane contamination in drinking water and has defined the daily allowance to be 2 ppb for adults and 0.5 ppb for children . Using the EPA-allowable levels and the average U.S. adult weight of 180 pounds (81.6 kg), and assuming the proven bioaccumulation in fat, , an adult would have to drink chlordane contaminated water for ∼603 days to reach our measured EC50 of 12 μM (see calculation in the Supporting Information). With levels of chlordane in the environment measured far above 2 ppb (for example, 530 ppb in soil measured in 2018) and the biomagnification due to the rapid accumulation of cis- chlordane into fats, , it is highly probable that over a lifetime, a person could reach the cis- chlordane levels measured here.…”

Nicotinamide-Modified poly(HEMA-GMA)-Nic Cryogels for Removal of Pesticides

“…Monitoring, removal and degradation studies have been performed up to date to deal with the persistent organic pollutants resistant to degradation (7,(15)(16)(17)(18)(19)(20)(21)(22)(23). These methods have disadvantages such as the need for experienced users, harmful chemicals, long-term experimental procedure.…”

“…Chlordane was at the forefront of 12 prohibited pesticides in the UNER Stockholm Convention, which was signed on persistent organic pollutants in 2001 (3). As a broadspectrum pesticide used against insects and pests in many vegetable and fruit cultures, chlordane, which has been used for many years in the United States of America (after the 1940s) and Japan (1980s), is almost insoluble in water, like other pesticides (4)(5)(6)(7). Chlordane, which is considered to be one of the most harmful members of pesticides, is profoundly harmful to health, and a severe endocrine disruptor (8)(9)(10)(11).…”