Determination of chloramphenicol at ultra-trace levels by high-performance differential pulse polarography

Reactant adsorption in analytical pulse voltammetry: Methodology and recommendations (Technical Report)

“…A well-known example in the latter category is the induced adsorption of metal ions in systems with adsorbing ligands. Systems for which reactant adsorption has definitely been shown to affect the pulse polarogram are for instance Cul, Cull, Cdll, Znll, Pbll in solutions containing bromide [4], iodide [5], pyrocatechol [6,7], amino acids [a], fulvic/humic acids [9] benzenelpyridine carboxylic acids [lo], polyelectrolytes [l 11 and solutions of nitro compounds [12], pyridines, substituted pyridine N-oxides, substituted azobenzenes [13], DNA [14], chloramphenicol [15], berberine 1161. This list is certainly not exhaustive and keeps on growing.…”

Physicochemical methods for pharmacokinetic and residue analysis of chloramphenicol and degradation products in dairy cows

“…The addition of ammonia buffer also helps in preventing emulsification, but was intended mainly to prevent endogenous riboflavin from being co-extracted. The reproducibility of the total procedure is reflected by the RSD of the three calibration curves used: 1.1%, 0.9% and 1.7% for the ranges 1-10, 0.1-1 and 0.01-0.1 pg ml-', respectively (averages of four curves per range; Van der Lee et al, 1980). The relative standard deviation for a single determination varied from 4% in the higher range to 10% in the lower range.…”

“…In a previous paper (Van der Lee, Van Bennekom & De Jong, 1980) it was shown that chloramphenicol may be determined in blood and milk down to levels of 20 ng ml-' by means of high performance, differential pulse polarography (HPDPP) with prior extraction. Recently, the same was demonstrated for high-performance liquid chromatography (HPLC) with ultraviolet (u.v.)…”

On-Line Pharmacokinetics of Chloramphenicol in Rat Cortex by in vivo Electrochemical Detection

“…Recent studies have shown that in vivo electroactive neurotransmitters in the extravascular space of the rat brain could be determined by in vivo electrochemistry [2,3]. Many drugs are electroactive and chloramphenicol has been evaluated several times by polarography [4,5]. In or der to monitor drug concentrations in the rat cortex, we developed a microelectrode which measured on-line the chloramphen icol concentration in the rat frontal cortex by differential pulse voltametry.…”