Determination of celecoxib in human plasma by high-performance liquid chromatography

Jalalizadeh, Hassan; Amini, Mohsen; Ziaee, Vahid; Safa, Ali; Farsam, Hassan; Shafiee, Abbas

doi:10.1016/j.jpba.2004.02.005

Cited by 39 publications

(31 citation statements)

References 8 publications

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“…A sensitive, accurate and validated reverse phase HPLC method was used (Ahmad et al, 2008;Itthipanichpong et al, 2005;Guirguis et al, 2001;Jalalizadeh et al, 2004). A brief description of method is given here.…”

Section: Hplc Analysismentioning

confidence: 99%

Bioequivalence assessment of two formulations of celecoxib: Open label, single dose and two-way cross over study in healthy human male volunteers

Akhtar

Ahmad²,

Ahmad³

et al. 2011

Afr. J. Pharm. Pharmacol.

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The purpose of this study was to assess bioequivalence of two marketed formulations of celecoxib capsules in healthy human male volunteers. The study was conducted according to a single dose, randomized sequence, open label, two-period and crossover design. Both test and reference formulations comprised labeled dose of 200 mg celecoxib and were administered to each subject after an overnight fasting on two treatment days separated by one week of washout period. After drug administration, blood samples were collected at predetermined time points for a period of 48 h. Plasma separated from blood was analyzed for celecoxib concentrations using validated reverse phase-high performance liquid chromatographic (RP-HPLC) method. Various pharmacokinetic parameters including C max , T max , AUC 0-t , AUC 0-∞ , T 1/2 and K el were determined from the plasma concentration for both formulations. C max , AUC 0-t and AUC 0-∞ , were evaluated for bioequivalence after log-transformation of data. The 90% confidence intervals for the ratio of C max (93.26 to 100.70%), AUC 0-t (87.00 to 117.50%) and AUC 0-∞ (86.49 to 118.56%), values for the test and reference products were within the acceptance range of 80 to 125%, proposed by Food and Drug Administration (FDA) and European Medicines Evaluation Agency (EMEA). Based on these statistical inferences, it was concluded that two formulations of celecoxib are bioequivalent in their rate and extent of absorption.

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Section: Hplc Analysismentioning

confidence: 99%

Bioequivalence assessment of two formulations of celecoxib: Open label, single dose and two-way cross over study in healthy human male volunteers

Akhtar

Ahmad²,

Ahmad³

et al. 2011

Afr. J. Pharm. Pharmacol.

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“…Thus, by controlling the accumulation time, we could effectively utilize the PANI-g-MWNT-ME for the sensitive detection of CEL. It is important to note that, the detection level of CEL (1 × 10 −11 M) at PANI-g-MWNT-ME is much higher than reported using hanging mercury drop electrode [4] and also by other techniques such as spectrophotometry, chromatography and fluorimetric methods [5][6][7][8][9][10][11][12].…”

Section: Optimization Of Experimental Parameters In Swsvmentioning

confidence: 99%

“…A survey of literature reveals that several analytical methods have been utilized for the quantitative determination of CEL in pharmaceutical formulation and human plasma. These methods include voltammetry [4], spectrophotometry [5], thin-layer chromatography [6], liquid chromatography [7], solid-phase extraction and high-performance liquid chromatography [8], micellar electro kinetic chromatography [9], liquid chromatography-mass spectrometry [10], high-performance liquid chromatography with UV [11] and fluorimetric [12] detections. Among the various methods, electrochemical methods have attracted interest because of their quick response, high sensitivity and the possibilities for miniaturization.…”

Section: Introductionmentioning

confidence: 99%

Electrochemical detection of celecoxib at a polyaniline grafted multiwall carbon nanotubes modified electrode

Manesh

Santhosh

Komathi

et al. 2008

Analytica Chimica Acta

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“…Several analytical methods have been reported for the analysis of CEL in human serum, among which are voltammetry, 4 spectrophotometry, 5 thin-layer chromatography, 6 liquid chromatography, 7 solid-phase extraction and high-performance liquid chromatography, 8 micellar electrokinetic chromatography, 9 liquid chromatography-mass spectrometry, 10 high-performance liquid chromatography with UV 11 and fluorometric 12 detections. These methods usually possess low sensitivity, are time consuming, need large sample volumes and some of them require a preconcentration step.…”

Section: Introductionmentioning

confidence: 99%

Electrochemical Determination of Celecoxib on a Graphene Based Carbon Ionic Liquid Electrode Modified with Gold Nanoparticles and Its Application to Pharmaceutical Analysis

et al. 2013

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A graphene-based carbon ionic liquid electrode modified with gold nanoparticles was fabricated. The electrochemical response of the modified electrode toward celecoxib was studied by means of cyclic voltammetry and differential pulse voltammetry. The structural morphology of the modified electrode was characterized by a scanning electron microscopy technique and electrochemical impedance spectroscopy. The prepared electrode showed excellent electrocatalytic activity in the reduction of celecoxib in a phosphate buffer solution, leading to remarkable enhancements in the corresponding peak currents and lowering of the peak potential. The advantages are related to the unique properties of graphene and gold nanoparticles such as a large surface area and increased electron-transfer abilities. Differential pulse voltammetry was applied to the quantitative determination. The calibration curve was linear in the concentration range of 0.5 to 15 μM and the detection limit was about 0.2 μM (Sb/N = 3). The proposed electrochemical sensor was successfully applied to the determination of celecoxib in real samples.

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Determination of celecoxib in human plasma by high-performance liquid chromatography

Cited by 39 publications

References 8 publications

Bioequivalence assessment of two formulations of celecoxib: Open label, single dose and two-way cross over study in healthy human male volunteers

Bioequivalence assessment of two formulations of celecoxib: Open label, single dose and two-way cross over study in healthy human male volunteers

Electrochemical detection of celecoxib at a polyaniline grafted multiwall carbon nanotubes modified electrode

Electrochemical Determination of Celecoxib on a Graphene Based Carbon Ionic Liquid Electrode Modified with Gold Nanoparticles and Its Application to Pharmaceutical Analysis

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