Determination of Carrier-Mediated Transport of 2 ,3 -Dideoxypurine Nucleosides in the Rat Ileum Using a Bidirectional Perfusion Technique

Abstract

Symmetric transport was demonstrated for urea and mannitol as expected for these passive permeability markers. F-ddI and ddI were shown to be preferentially transported from blood to lumen. The basolateral to luminal transport of ddI is saturable, inhibited by probenecid, and sodium ion dependent. These results are consistent with carrier-mediated uptake on the basolateral membrane.