Determination of carotid plaque risk by ultrasonic tissue characterization

Lee, Daniel J; Sigel, Bernard; Swami, Vanlila K.; Justin, Jeffery; Gahtan, Vivian; O’Brien, Sean; Dwyer-Joyce, Lisa; Feleppa, Ernest J.; Ab, Roberts; Berkowitz, Henry D.

doi:10.1016/s0301-5629(98)00125-2

Cited by 30 publications

(15 citation statements)

References 27 publications

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“…Ophthalmologists should take an integrated approach, by promptly checking the blood supply of the carotid artery and by selecting Doppler ultrasound over other techniques as the preliminary screen of choice, because it is safe, quick and cost effective. The accuracy of diagnostic ultrasonic examinations and performing digital subtractive angiography upon the carotid artery is up to 90 per cent and the accuracy of identifying plaque tissue is up to 88.2 per cent 22 . If the signs are positive, magnetic resonance angiography and digital subtractive angiography should be applied to make the final diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Preliminary clinical analysis of neovascular glaucoma secondary to carotid artery disease

Zhou

Wei

2011

Clinical and Experimental Optometry

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Background: Neovascular glaucoma (NVG) is a rare but severe complication of hypoperfusion retinopathy. Our objective was to analyse the clinical features of NVG secondary to carotid artery atherosclerosis, moyamoya disease and Takayasu arteritis. Methods: Thirty-six cases (36 eyes) with hypoperfusion retinopathy associated with NVG were retrospectively analysed. Each patient had their visual acuity assessed and fundus examined by fundus fluorescein angiography, colour Doppler flow imaging, magnetic resonance angiography, digital subtraction angiography and other techniques. Results: Eyes belonging to 30 males and six females were analysed. There were 24 right eyes and 12 left eyes. The ages of these patients ranged 18 to 78 years and the mean age was 40 years. The visual acuities ranged from light perception to 0.8 (decimal notation). Posterior segment manifestations included mid-peripheral intraretinal haemorrhages and narrowed retinal arteries. All eyes were associated with either an ipsilateral common carotid artery obstruction or a severe bilateral obstruction of the internal carotid arteries. Conclusions:The characteristic clinical features are presented during the process of the disease. Degeneration of the ocular fundus was predominantly on one side. The retinal manifestations included mid-peripheral haemorrhages and dilated retinal veins. High intraocular pressure and excavation and atrophy of the optic disc were common. In the eyes that were examined, neovascularisation was observed in the iris and anterior chamber and various visual field defects were present.

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Section: Discussionmentioning

confidence: 99%

Preliminary clinical analysis of neovascular glaucoma secondary to carotid artery disease

Zhou

Wei

2011

Clinical and Experimental Optometry

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“…In addition, laser induced fluorescence spectroscopy may aid the determination of carotid plaque risk by identifying unstable plaque with a central lipid core or arterial thrombus that has the potential to produce acute plaque rupture and arterial thrombosis [33]. Risk assessment of thromboembolism resulting from carotid atherosclerotic disease is the subject of investigation by different techniques, for example, by ultrasonic tissue characterization [34]; thus, the performance of noninvasive clinical diagnosis is particularly important.…”

Section: Discussionmentioning

confidence: 99%

Spectroscopic characterisation of carotid atherosclerotic plaque by laser induced fluorescence

et al. 2000

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“…Studies using conventional ultrasound B-mode have revealed the inability of identify the vulnerable plaque 12 , in part due to the qualitative nature of B-mode images and in part due to the phase aberration by of the intervening soft tissue. In contrast, ultrasound tissue characterization, such as a technique based on spectral analysis of the backscattered RF signal 13 , can characterization plaques with moderate accuracy.…”

Section: Motivation For the Integrated Backscatter Approachmentioning

confidence: 99%

Ultrasound characterization of arterial wall structures based on integrated backscatter profiles

2003

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Studies suggest that the composition of atherosclerotic plaque in the carotid arteries is predictive of stroke risk. The goal of this investigation has been to explore how well the true integrated backscatter (IBS) from plaque regions can be measured non-invasively using ultrasound, based on which plaque composition may be inferred. To obtain the true arterial IBS non-invasively, the scattering and aberating effect of the intervening tissue layers must be overcome. This is achieved by using the IBS from arterial blood as a reference backscatter, specifically the backscatter from a blood volume along the same scan line as and adjacent to the region of interest. The arterial blood IBS is obtained as an estimated mean of a stochastic process, after clutter removal. We have shown that the variance of the IBS estimate of the blood backscatter signal can be quantified and reduced to a tolerable level. The results are in the form of IBS profiles along the vessel. IBS profiles not normalized with the IBS of the blood-mimicking fluid have been measured for vessels phantom, with and without an intervening inhomogeneous medium; these results are contrasted with the corresponding normalized IBS profiles.

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Determination of carotid plaque risk by ultrasonic tissue characterization

Cited by 30 publications

References 27 publications

Preliminary clinical analysis of neovascular glaucoma secondary to carotid artery disease

Preliminary clinical analysis of neovascular glaucoma secondary to carotid artery disease

Spectroscopic characterisation of carotid atherosclerotic plaque by laser induced fluorescence

Ultrasound characterization of arterial wall structures based on integrated backscatter profiles

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