Determination of Cardiac Output in Man by a New Method Based on Thermodilution

Khalil, Hassan H.

doi:10.1016/s0140-6736(63)91928-7

Cited by 29 publications

(5 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Through right heart catheterization, the TD method and Steward-Hamilton equation that utilizes temperature change over time has become the most common method of CO estimation in critically ill patients. [4][5][6] However, no method of CO estimation is perfect, and multiple clinical limitations of the TD method exist. [7][8][9][10] Technical issues can also affect the validity of TD, including computer calibration, catheter placement, rate of injection, temperature and volume of the injectate, timing of the injection during the respiratory cycle, and the position of the subject.…”

Section: Discussionmentioning

confidence: 99%

“…The diagnosis and treatment of pulmonary hypertension often requires right heart catheterization procedures to assess pulmonary artery pressures, pulmonary vascular resistance, and CO. A truly continuous measurement of CO would be desirable to clinicians treating a variety of chronic and acute diseases, including pulmonary hypertension and heart failure. Through right heart catheterization, the TD method and Steward‐Hamilton equation that utilizes temperature change over time has become the most common method of CO estimation in critically ill patients 4–6 . However, no method of CO estimation is perfect, and multiple clinical limitations of the TD method exist 7–10 .…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Comparison of Impedance Cardiography to Direct Fick and Thermodilution Cardiac Output Determination in Pulmonary Arterial Hypertension

Yung

Fedullo

Kinninger

et al. 2004

Congestive Heart Failure

View full text Add to dashboard Cite

Cardiac output (CO) is an important diagnostic and prognostic tool for patients with ventricular dysfunction. Pulmonary hypertension patients undergo invasive right heart catheterization to determine pulmonary vascular and cardiac hemodynamics. Thermodilution (TD) and direct Fick method are the most common methods of CO determination but are costly and may be associated with complications. The latest generation of impedance cardiography (ICG) provides noninvasive estimation of CO and is now validated. The purpose of this study was to compare ICG measurement of CO to TD and direct Fick in pulmonary hypertension patients. Thirty-nine enrolled patients were analyzed: 44% were male and average age was 50.8+/-17.4 years. Results for bias and precision of cardiac index were as follows: ICG vs. Fick (-0.13 L/min/m2 and 0.46 L/min/m2), TD vs. Fick (0.10 L/min/m2 and 0.41 L/min/m2), ICG vs. TD (respectively, with a 95% level of agreement between -0.72 and 0.92 L/min/m2; CO correlation of ICG vs. Fick, TD vs. Fick, and ICG vs. TD was 0.84, 0.89, and 0.80, respectively). ICG provides an accurate, useful, and cost-effective method for determining CO in pulmonary hypertension patients, and is a potential tool for following responses to therapeutic interventions.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Comparison of Impedance Cardiography to Direct Fick and Thermodilution Cardiac Output Determination in Pulmonary Arterial Hypertension

Yung

Fedullo

Kinninger

et al. 2004

Congestive Heart Failure

View full text Add to dashboard Cite

show abstract

“…2 When a PVR is unable to be calculated given an unobtainable PAOP, one can calculate the total pulmonary resistance (mPAP/CO). In addition, the RHC provides the following measured hemodynamic data: right atrial pressure (RAP), right ventricular pressure (RVP), mixed venous oxygenation (mvO 2 ) AE superior/inferior vena cava (SVC/IVC) oxygenation, transpulmonary gradient (mPAP -downstream pressure), and cardiac output (either by thermo-dilution 118 or by using the Fick principle 119 ). The interpretation of hemodynamic tracings should be performed by experienced clinicians, and all measurements should be made during end-expiration.…”

Section: Cardiac Catheterizationmentioning

confidence: 99%

Diagnosis and Hemodynamic Assessment of Pulmonary Arterial Hypertension

Saggar

Aboulhosn³

et al. 2009

Semin Respir Crit Care Med

View full text Add to dashboard Cite

Pulmonary hypertension (PH) can occur as either a primary or a secondary process, and in general, its presence increases overall morbidity and mortality. Importantly, the majority of prior studies have been in the setting of idiopathic pulmonary arterial hypertension (IPAH); thus the following discussion focuses on IPAH. Because the majority of available diagnostic strategies lack sensitivity and specificity, the physician must maintain a high index of suspicion in considering PAH. This article provides an overview of the available diagnostic studies for PAH with a particular focus on hemodynamic assessment. Novel approaches to the often delayed diagnosis of PAH are being studied and are also discussed here.

show abstract

“…Cardiac output determined by thermodilution, is described by Khalil et al [21] or by the estimated Fick principle, where cardiac output (CO) equals oxygen consumption (VO 2 ) divided by the difference between the concentration of arterial oxygen (CaO 2 ) and concentration of mixed venous oxygen content (CvO 2 ) [24]:…”

Section: Rhc Assessment Of Pahmentioning

confidence: 99%