Determination of captopril in human serum by high performance liquid chromatography using solid-phase extraction

Development and Validation of an HPLC Method for the Simultaneous Analysis of 23 Selected Drugs Belonging to Different Therapeutic Groups in Human Urine Samples

“…[1][2][3] Different analytical methods have been applied to the determination of the remaining drugs analyzed by us, and also by HPLC techniques. Many of the HPLC analytical methods exist for the assay of ENA, [4][5][6][7] SOT, [8][9][10][11][12][13][14][15] CAP, [16][17][18][19][20][21][22][23][24] MET, [25][26][27][28][29][30][31] 62,63 and SPI [64][65][66][67][68] in different biological fluids and tissues. HPLC methods were applied to the simultaneous quantification of selected β-blockers (also: SOT, MET and PRO) in human fluids (plasma, serum, urine).…”

Highly selective and sensitive voltammetric sensor for captopril determination based on modified multiwall carbon nanotubes paste electrode

“…5 Therefore, determination of this compound is very important. Various instrumental methods have been developed for the determination of captopril including high-performance liquid chromatography, [6][7][8][9][10] Highly Selective and Sensitive Voltammetric Sensor for Captopril Determination [30][31][32][33][34] The comparisons of the proposed method for captopril determination with the other electrochemical published papers are given in Table 1. Carbon nanotubes (CNTs) continue to receive considerable attention in electrochemistry.…”

Comparative Study of Captopril Derivatization Reaction by LC-UV, LC-MS and CE-UV Methods

“…In our case the UV active agent was p-bromophenacyl bromide (p-BPB), which prevents captopril binding to plasma constituents and is also a chemical stabilizer. [5][6][7][8] The resulted product can be determined at a more specific wavelength (λ = 260 nm). The possible reaction between the derivatizing agent and captopril involves the -SH group of the latter and the carbocation of the alkylhalide, 9 resulting a derivative with greater molecular mass and less polarity ( Figure 1).…”