Determination of cannabinoids in 50 μL whole blood samples by online extraction using turbulent flow chromatography and LC‐HRAM‐Orbitrap‐MS: Application on driving under the influence of drugs cases
Abstract:The analysis of cannabinoids in whole blood is usually done by traditional mass spectrometry (MS) techniques, after offline cleanup or derivatization steps which can be lengthy, laborious, and expensive. We present a simple, fast, highly specific, and sensitive method for the determination of Δ9‐tetrahydrocannabinol (THC), cannabidiol (CBD), cannabinol (CBN), 11‐hydroxy‐Δ9‐tetrahydrocannabinol (11‐OH‐THC), and 11‐nor‐9‐carboxy‐Δ9‐tetrahydrocannabinol (THC‐COOH) in 50 μL whole blood samples. After the addition … Show more
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