Determination of calibration curves for 131I in thyroid tumour metabolic radiotherapy and other radionuclides used in SPECT imaging

Arginelli, D.; Heikkonen, Jorma; Miranti, A.; Peroni, C.; Ridone, S.; Vigna, L.

doi:10.1007/s10967-009-0296-z

Cited by 5 publications

(5 citation statements)

References 13 publications

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“…OMP was radioiodinated by direct electrophilic substitution reaction with Na 125 I in the existence of CAT as oxidizing agent according to Equation (5).…”

Section: Resultsmentioning

confidence: 99%

“…Usually, the emitted radiation by the utilized isotope completely vanishes after 1 day through normal body excretion and radioactive decay. The most usable isotopes in these purposes were 99m Tc, 181 Re, 131 I, etc . Radiolabeling of molecules with iodine nuclides (radioiodination) is of great importance in pharmaceutical radiochemistry.…”

Section: Introductionmentioning

confidence: 99%

“…The most usable isotopes in these purposes were 99m Tc, 181 Re, 131 I, etc. 4,5 Radiolabeling of molecules with iodine nuclides (radioiodination) is of great importance in pharmaceutical radiochemistry. Techniques used to incorporate radioiodine into one molecule must be biocompatible with the labeled one and must be able to provide good yields, stability, and an unaltered bioactivity of the products.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Facile radiolabeling optimization process via design of experiments and an intelligent optimization algorithm: Application for omeprazole radioiodination

Farrag

Abdel-Halim

Moamen

2019

Labelled Comp Radiopharmac

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The major uses of radiopharmaceuticals (RP) in clinical areas are diagnosis and/or therapy. The present study aimed to utilize the application of fractional factorial design analysis (FFDA) coupled with particle swarm optimization algorithm (PSO) to assess the optimization of RP production process. In this regard, omeprazole (OMP), which is gastric parietal cell proton pump inhibitor (PPI), was radiolabeled with iodine‐125 (125I) isotope in order to be used as a radiotracer for stomach imaging. Different factors that affect radiolabeling process were studied. According to the proposed design, just 16 experimental runs of radiolabeling process were performed using the extremes of each factor. In addition, one run was executed at the mean point of each factor. Undesirable maximum radiolabeling yield (RY) of radioiodinated omeprazole (125I‐OMP) was deduced from application of FFDA (88.4%). Furthermore, after applying PSO with changing limits of one factor, the maximum RY of 125I‐OMP was found to be 93.78%. Moreover, the practically verification from optimum conditions, which obtained from PSO, was found to give an RY of 93.99%. Overall, the findings of this study confirmed the potential use of that hybrid design for optimization of radiolabeling processes.

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“…OMP was radioiodinated by direct electrophilic substitution reaction with Na 125 I in the existence of CAT as oxidizing agent according to Equation (5).…”

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Facile radiolabeling optimization process via design of experiments and an intelligent optimization algorithm: Application for omeprazole radioiodination

Farrag

Abdel-Halim

Moamen

2019

Labelled Comp Radiopharmac

View full text Add to dashboard Cite

show abstract

“…In vitro and in vivo diagnostic researches in nuclear medicine use radioisotopes and radiopharmaceuticals. Many tracers were used like TC-99m, Re-181, I-131, and others [1][2][3]. Also many compounds were subjected to be labeled with these radioisotopes like MAG3, MDP, DTPA and others [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Labeling of tannic acid with technetium-99m for diagnosis of stomach ulcer

2013

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Tannic acid is a polyphenolic compound that could be labeled with technetium-99m. To produce about 90% yield of 99m Tc-tannic acid in acidic media (pH), the conditions required were 150 µg tin chloride, 30 min reaction time, and 200 µg of the substrate. 99m Tc-tannic was stable for 6 h. Oral biodistribution of 99m Tc-tannic showed that it concentrated in the stomach ulcer to reach about 50% of the total injected dose at 1 h after orall administration. This concentration of 99m Tc-tannic in stomach ulcer may be sufficient to radio-image the presence of ulcer in the stomach.

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“…In vitro and in vivo diagnostic researches in nuclear medicine use radioisotopes and radiopharmaceuticals. Many tracers were used like TC-99m, Re-181, I-131, and others [ 1 – 3 ]. Also many compounds were subjected to be labeled with these radioisotopes like MAG3, MDP, DTPA and others [ 4 – 6 ].…”

Section: Introductionmentioning

confidence: 99%

Labeling of Tannic Acid with Technetium-99m for Diagnosis of Stomach Ulcer

2011

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Tannic acid is a polyphenolic compound that could be labeled with technetium-99m. To produce about 90% yield of 99mTc-tannic acid in acidic media (pH), the conditions required were 150 μg tin chloride, 30 min reaction time, and 200 μg of the substrate. 99mTc-tannic was stable for 6 h. Oral biodistribution of 99mTc-tannic showed that it concentrated in the stomach ulcer to reach about 50% of the total injected dose at 1 h after orall administration. This concentration of 99mTc-tannic in stomach ulcer may be sufficient to radio-image the presence of ulcer in the stomach.

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Determination of calibration curves for 131I in thyroid tumour metabolic radiotherapy and other radionuclides used in SPECT imaging

Cited by 5 publications

References 13 publications

Facile radiolabeling optimization process via design of experiments and an intelligent optimization algorithm: Application for omeprazole radioiodination

Facile radiolabeling optimization process via design of experiments and an intelligent optimization algorithm: Application for omeprazole radioiodination

Labeling of tannic acid with technetium-99m for diagnosis of stomach ulcer

Labeling of Tannic Acid with Technetium-99m for Diagnosis of Stomach Ulcer

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