Determination of bromate in drinking waters using low pressure liquid chromatography/ICP-MS

Abstract

This paper describes a user-friendly method for bromate determination that can be implemented easily on any inductively coupled plasma-mass spectrometer present in drinking water laboratories. The method uses low pressure liquid chromatography coupled to an ICP-quadrupole mass spectrometry instrument (ICP-QMS) or an ICP-sector field mass spectrometry instrument (ICP-SFMS) and is compared to that relying on high performance liquid chromatography (HPLC) coupled to an ICP-QMS instrument. The low pressure LC/ICP-MS method uses a low-pressure delivery six-port valve and a 5 cm anion exchange column, which allows a fully resolved separation of bromate in 13 min and achieves a limit of quantification of 0.2 mu g bromate L-1. The low pressure LC system is small and easy to install and its operation is fully integrated within the ICP-MS software. The method allows fit-for-purpose assessment of bromate, potentially present as a Br-containing disinfection by-product in drinking water, and meets all performance characteristic requirements set by the European Council for the monitoring of the quality of water intended for human consumption. A median bromate concentration of 0.5 mu g L-1 was obtained for 80 tap water samples collected during regulatory monitoring campaigns from 2009 until 2012 and covering different water supply areas in the Flemish region of Belgium

Glycine and Selenium (Separately and in Combination) Reduced Bromate-Mediated Oxidative Stress and Inflammatory Response in U937 Cells

“…Bromate (as potassium bromate) is an additive in bread making and a disinfection by-product in the treatment of water via ozonation [1,2]. Bromate is used in bread because it is cheap, possesses the most efficient oxidizing property, helps bread to rise in the oven and to create a good texture [2,3].…”

Atomic spectrometry update: review of advances in the analysis of clinical and biological materials, foods and beverages

“…An easily-implemented ICP-MS method for determination of organic and inorganic Br concentrations in drinking water, which can replace HPLC with low pressure LC, was proposed by Tirez et al 157 The system comprised a peristaltic pump operating at 170 mL min À1 as part of the FI system which included the spectrometer's autosampler and a 50 mL baffled cyclonic spray chamber. An easily-implemented ICP-MS method for determination of organic and inorganic Br concentrations in drinking water, which can replace HPLC with low pressure LC, was proposed by Tirez et al 157 The system comprised a peristaltic pump operating at 170 mL min À1 as part of the FI system which included the spectrometer's autosampler and a 50 mL baffled cyclonic spray chamber.…”

“…7.1.6 Drinking water and non-alcoholic beverages. An easily-implemented ICP-MS method for determination of organic and inorganic Br concentrations in drinking water, which can replace HPLC with low pressure LC, was proposed by Tirez et al 157 The system comprised a peristaltic pump operating at 170 mL min À1 as part of the FI system which included the spectrometer's autosampler and a 50 mL baffled cyclonic spray chamber. An anion exchange column was used with NH 4 NO 3 as mobile phase; the BrO 3 À ion eluted in 13 min and an LOD of 0.2 mg L À1 was achieved.…”