Determination of Brain Death

Brasil, Sérgio; Nogueira, Ricardo de Carvalho; Oliveira, Marcelo de Lima

doi:10.1001/jama.2020.23225

Cited by 4 publications

(2 citation statements)

References 4 publications

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“…The case group comprised nine patients (F: M = 4:5); the average age was 48.5 years, ranging from 21 to 61. The underlying diseases of these patients were: hemorrhagic stroke (4), brain neoplasms (1), and closed head injury (1).…”

Section: Resultsmentioning

confidence: 99%

Qualitative Evaluation of Intracranial Pressure Slopes in Patients Undergoing Brain Death Protocol

Ideta¹,

Oliveira²,

Gonçalves³

et al. 2023

Preprint

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Background: Due to the importance of brain death (BD) diagnostic do not mistake, reliable confirmatory exams should be performed to enhance its security. This study aims to evaluate the intracranial pressure (ICP) pulse morphology behavior in brain-dead patients through a noninvasive monitoring system. Methods: A pilot case-control study was conducted in adults that met the BD national protocol criteria. Quantitative data from the ICP waveforms were extracted and analyzed comparing BD patients and health subjects. Results: Fifteen patients were included. ICP waveforms presented substantial differences amidst BD patients when compared to the control group. Moreover, pulse amplitude and time to peak variables values in the case group were also statistically significant. Conclusions: In this exploratory study, noninvasive ICP waveforms have shown potential as a screening method in patients with suspected brain death. Future studies should be carried out in a larger population.

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Section: Resultsmentioning

confidence: 99%

Qualitative Evaluation of Intracranial Pressure Slopes in Patients Undergoing Brain Death Protocol

Ideta¹,

Oliveira²,

Gonçalves³

et al. 2023

Preprint

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show abstract

“…The neurological determination of death, or brain death (BD), must follow rigorous medical standards in order to not allow mistakes [ 1 , 2 , 3 ]. Although in some countries the diagnosis of BD is given solely by clinical examination, in others, such as in Brazil, ancillary exams are necessary to complement the neurological assessment [ 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

Qualitative Evaluation of Intracranial Pressure Slopes in Patients Undergoing Brain Death Protocol

et al. 2023

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Background: Due to the importance of not mistaking when determining the brain death (BD) diagnostic, reliable confirmatory exams should be performed to enhance its security. This study aims to evaluate the intracranial pressure (ICP) pulse morphology behavior in brain-dead patients through a noninvasive monitoring system. Methods: A pilot case-control study was conducted in adults that met the BD national protocol criteria. Quantitative parameters from the ICP waveforms, such as the P2/P1 ratio, time-to-peak (TTP) and pulse amplitude (AMP) were extracted and analyzed comparing BD patients and health subjects. Results: Fifteen patients were included, and 6172 waveforms were analyzed. ICP waveforms presented substantial differences amidst BD patients when compared to the control group, especially AMP, which had lower values in patients diagnosed with BD (p < 0.0001) and the TTP median (p < 0.00001), but no significance was found for the P2/P1 ratio (p = 0.8). The area under curve for combination of parameters on the BD prediction was 0.77. Conclusions: In this exploratory study, noninvasive ICP waveforms have shown potential as a screening method in patients with suspected brain death. Future studies should be carried out in a larger population.

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Mistaken concepts on the use of ancillary testing in brain death diagnosis

Brasil

2021

Can J Anesth/J Can Anesth

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Determination of Brain Death

Cited by 4 publications

References 4 publications

Qualitative Evaluation of Intracranial Pressure Slopes in Patients Undergoing Brain Death Protocol

Qualitative Evaluation of Intracranial Pressure Slopes in Patients Undergoing Brain Death Protocol

Qualitative Evaluation of Intracranial Pressure Slopes in Patients Undergoing Brain Death Protocol

Mistaken concepts on the use of ancillary testing in brain death diagnosis

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